Gerard R. Dawson

Best Publications

• Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

  R M McKernan;T W Rosahl;D S Reynolds;C Sur

  1158
  Citations

• β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

  Hui Zheng;Minghao Jiang;Myrna E. Trumbauer;Dalip J.S. Sirinathsinghji

  928
  Citations

• Use of the elevated plus maze in the search for novel anxiolytic agents

  Gerard R. Dawson;Mark D. Tricklebank

  737
  Citations

• Sedation and Anesthesia Mediated by Distinct GABAA Receptor Isoforms

  David S. Reynolds;Thomas W. Rosahl;Jennifer Cirone;Gillian F. O'Meara

  342
  Citations

• Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein.

  G.R. Seabrook;D.W. Smith;B.J. Bowery;A. Easter

  332
  Citations

• Evidence for a Significant Role of α3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines

  Rebecca Dias;Wayne F. A. Sheppard;Rosa L. Fradley;Elizabeth M. Garrett

  311
  Citations

• An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

  G. R. Dawson;K. A. Maubach;N. Collinson;M. Cobain

  299
  Citations

• Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice.

  Cyrille Sur;Keith A. Wafford;David S. Reynolds;Karen L. Hadingham

  270
  Citations

• TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

  John R. Atack;Keith A. Wafford;Spencer J. Tye;Susan M. Cook

  266
  Citations

• Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates.

  James K. Rowlett;Donna M. Platt;Snjezana Lelas;John R. Atack

  259
  Citations

• The mouse beam walking assay offers improved sensitivity over the mouse rotarod in determining motor coordination deficits induced by benzodiazepines.

  Joanna L. Stanley;Rachael J. Lincoln;Terry A. Brown;Louise M. McDonald

  244
  Citations

• L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors

  John R. Atack;Peter J. Bayley;Guy R. Seabrook;Keith A. Wafford

  223
  Citations

• Evidence that the anxiolytic-like effects of chlordiazepoxide on the elevated plus maze are confounded by increases in locomotor activity.

  G. R. Dawson;S. P. Crawford;N. Collinson;S. D. Iversen

  206
  Citations

• Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition

  Mark S. Chambers;John R. Atack;Howard B. Broughton;Neil Collinson

  193
  Citations

• 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.

  Robert W Carling;Kevin W Moore;Leslie J Street;Deborah Wild

  186
  Citations

• A quantitative trait locus influencing anxiety in the laboratory rat.

  Alberto Fernández-Teruel;Rosa M. Escorihuela;Jeffrey A. Gray;Raúl Aguilar

  179
  Citations

• Anxiogenic properties of an inverse agonist selective for α3 subunit-containing GABAA receptors

  John R Atack;Peter H Hutson;Neil Collinson;George Marshall

  177
  Citations

• Age-related neural activity during allocentric spatial memory

  Elena Antonova;D. Parslow;Michael Brammer;G. R. Dawson

  168
  Citations

• An Orally Bioavailable, Functionally Selective Inverse Agonist at the Benzodiazepine Site of GABAA α5 Receptors with Cognition Enhancing Properties

  Mark S. Chambers;John R. Atack;Robert W. Carling;Neil Collinson

  163
  Citations

• Selective, Orally Active γ-Aminobutyric AcidA α5 Receptor Inverse Agonists as Cognition Enhancers

  Francine Sternfeld;Robert W. Carling;Richard A. Jelley;Tamara Ladduwahetty

  162
  Citations