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D-Index & Metrics

Biology and Biochemistry

D-Index
97
Citations
31579
World Ranking
1764
National Ranking
115

Overview

Paul J. Whiting is a researcher affiliated with University College London in the United Kingdom, with a focus on biomedical sciences. Their work spans several interconnected fields, including Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Within these areas, they have contributed extensively to Molecular Biology, Neurology, Physiology, Cellular and Molecular Neuroscience, and Immunology.

Their research primarily addresses topics related to neuroinflammation and neurodegeneration mechanisms, Alzheimer's disease research and treatments, Wnt/β-catenin signaling in development and cancer, neuroscience and neuropharmacology research, genetics and neurodevelopmental disorders, cancer-related gene regulation, and autophagy in disease and therapy.

Frequent collaborators in their research include Sarah Jolly, Magda Bictash, Patricia C. Salinas, Amy E. Monaghan, and John Hardy.

Paul J. Whiting's work has been published in several scientific journals, with multiple publications in bioRxiv (Cold Spring Harbor Laboratory), the Journal of Medicinal Chemistry, and Zenodo (CERN European Organization for Nuclear Research). Other publication venues include Brain and Brain Sciences.

Significant recent papers authored or co-authored by Whiting include:

  • Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci, 2022, Brain
  • Dysregulated Wnt Signalling in the Alzheimer's Brain, 2020, Brain Sciences
  • Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling, 2021, Journal of Medicinal Chemistry
  • Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters, 2022, Molecular Psychiatry
  • 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit, 2020, Journal of Medicinal Chemistry

Best Publications

  • Which GABAA-receptor subtypes really occur in the brain?

    Ruth M. McKernan;Paul J. Whiting

  • Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

    R M McKernan;T W Rosahl;D S Reynolds;C Sur

  • DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.

    J. Kirsty Millar;Benjamin S. Pickard;Shaun Mackie;Rachel James

  • Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor

    Neil Collinson;Frederick M. Kuenzi;Wolfgang Jarolimek;Karen A. Maubach

  • Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors

    N Brown;J Kerby;T P Bonnert;P J Whiting

  • Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors.

    Stuart M. Chambers;Yuchen Qi;Yuchen Qi;Yvonne Mica;Gabsang Lee

  • Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration.

    Lyndon da Cruz;Kate Fynes;Odysseas Georgiadis;Odysseas Georgiadis;Odysseas Georgiadis;Julie Kerby

  • Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily

    Ralf Schoepfer;William G. Conroy;Paul Whiting;Martin Gore

  • Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site

    Paul Whiting;Ruth M. McKernan;Leslie L. Iversen

  • Disrupted in Schizophrenia 1 Interactome : evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia

    L. M. Camargo;L. M. Camargo;V. Collura;J.-C. Rain;K. Mizuguchi

  • Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.

    Xiao Peng;V. Gerzanich;R. Anand;P. J. Whiting

  • Molecular and functional diversity of the expanding GABA-A receptor gene family.

    Paul J. Whiting;Timothy P. Bonnert;Ruth M. Mckernan;Sophie Farrar

  • Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure.

    R Anand;W G Conroy;R Schoepfer;P Whiting

  • The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid

    Delia Belelli;Jeremy J. Lambert;John A. Peters;Keith Wafford

  • theta, a novel gamma-aminobutyric acid type A receptor subunit.

    T. P. Bonnert;R. M. Mckernan;S. Farrar;B. Le Bourdelles

  • Immunohistochemical localization of neuronal nicotinic receptors in the rodent central nervous system

    LW Swanson;DM Simmons;PJ Whiting;J Lindstrom

  • Purification and characterization of a nicotinic acetylcholine receptor from rat brain

    Paul J. Whiting;Jon M. Lindstrom

  • GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?

    Paul J Whiting

  • Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells

    T Priestley;P Laughton;J Myers;B Le Bourdellés

  • The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit

    Peter B. Wingrove;Keith A. Wafford;Corrina Bain;Paul J. Whiting

Frequent Co-Authors

Keith A. Wafford
Keith A. Wafford Eli Lilly (United States)
Ruth M. McKernan
Ruth M. McKernan MSD (United States)
Jon Lindstrom
Jon Lindstrom University of Pennsylvania
John R. Atack
John R. Atack Cardiff University
Thomas W. Rosahl
Thomas W. Rosahl MSD (United States)
R. Adron Harris
R. Adron Harris The University of Texas at Austin
Nicholas J. Brandon
Nicholas J. Brandon Neumora Therapeutics Inc
Larry W. Swanson
Larry W. Swanson University of Southern California
James M. Sikela
James M. Sikela University of Colorado Denver
David J. Porteous
David J. Porteous University of Edinburgh

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