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Medicine

D-Index
98
Citations
33654
World Ranking
8949
National Ranking
4604

Research.com Recognitions

  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Robert L. Macdonald is affiliated with Vanderbilt University Medical Center in the United States. Their research primarily focuses on neuroscience, biochemistry, genetics, molecular biology, and medicine, with a notable specialization in cellular and molecular neuroscience.

The scientist's main fields of study include:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, Macdonald's work examines several subfields such as:

  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Psychiatry and Mental health
  • Cognitive Neuroscience
  • Artificial Intelligence

Their research covers key topics including:

  • Neuroscience and Neuropharmacology Research
  • Epilepsy research and treatment
  • Genetics and Neurodevelopmental Disorders
  • Ion channel regulation and function
  • Infectious Encephalopathies and Encephalitis
  • Zebrafish Biomedical Research Applications
  • Epigenetics and DNA Methylation

Robert L. Macdonald has authored multiple papers, among which are the following recent publications:

  • Dravet syndrome-associated mutations in GABRA1, GABRB2, and GABRG2 define the genetic landscape of defects of GABAA receptors (2021), Brain Communications
  • GABAA receptor β3 subunit mutation D120N causes Lennox-Gastaut syndrome in knock-in mice (2020), Brain Communications
  • GABRG2 Variants Associated with Febrile Seizures (2023), Biomolecules
  • The GABRG2 F343L allele causes spontaneous seizures in a novel transgenic zebrafish model that can be treated with suberanilohydroxamic acid (SAHA) (2020), Annals of Translational Medicine
  • Endoplasmic reticulum stress increases inflammatory cytokines in an epilepsy mouse model Gabrg2+/Q390X knockin: A link between genetic and acquired epilepsy? (2020), Epilepsia

Frequent coauthors collaborating with Macdonald include:

  • Wangzhen Shen
  • Mackenzie A. Catron
  • Chengwen Zhou
  • Ningning Hu
  • Rachel Howe

The venues where Macdonald often publishes are:

  • Brain Communications
  • Biomolecules
  • Epilepsia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • arXiv (Cornell University)

Recognition for Macdonald's contributions includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2016 and membership in the Association of American Physicians.

Best Publications

  • GABAA Receptor Channels

    Robert L. Macdonald;Richard W. Olsen

  • It's Time to Revise the Definition of Status Epilepticus

    Daniel H. Lowenstein;Thomas P Bleck;Robert L. Macdonald

  • Antiepileptic Drug Mechanisms of Action

    Robert L. Macdonald;Kevin M. Kelly

  • Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit

    Kai M. Wohlfarth;Matt T. Bianchi;Robert L. Macdonald

  • Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function

    Delia Belelli;Neil L. Harrison;Jamie Maguire;Robert L. Macdonald

  • Rapid Seizure-Induced Reduction of Benzodiazepine and Zn2+ Sensitivity of Hippocampal Dentate Granule Cell GABAA Receptors

    Jaideep Kapur;Robert L. Macdonald

  • Assembly of GABAA receptor subunits: role of the delta subunit

    NC Saxena;RL Macdonald

  • Differential regulation of γ-aminobutyric acid receptor channels by diazepam and phenobarbital

    Roy E. Twyman;Carl J. Rogers;Robert L. Macdonald

  • GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies

    Leanne M. Dibbens;Hua-Jun Feng;Michaella C. Richards;Louise A. Harkin

  • Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.

    N C Saxena;R L Macdonald

  • GABAA receptor subunit γ2 and δ subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts

    Kevin F. Haas;Robert L. Macdonald

  • Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture.

    M J McLean;R L Macdonald

  • Benzodiazepines specifically modulate GABA-mediated postsynaptic inhibition in cultured mammalian neurones

    Robert Macdonald;Robert Macdonald;Jeffery L. Barker

  • Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neurones

    Robert L. Macdonald;Robert L. Macdonald;Jeffery L. Barker;Jeffery L. Barker

  • Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture

    Robert A. Gross;Robert L. MacDonald

  • Neurosteroid regulation of GABAA receptor single-channel kinetic properties of mouse spinal cord neurons in culture.

    R E Twyman;R L Macdonald

  • Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture.

    M J McLean;R L Macdonald

  • Anticonvulsant drugs: mechanisms of action.

    Macdonald Rl;McLean Mj

  • Mutations in GABAA receptor subunits associated with genetic epilepsies

    Robert L. Macdonald;Jing-Qiong Kang;Martin J. Gallagher

  • Cyclic AMP-dependent protein kinase decreases GABAA receptor current in mouse spinal neurons.

    Nada M. Porter;Roy E. Twyman;Michael D. Uhler;Robert L. Macdonald

Frequent Co-Authors

Robert A. Gross
Robert A. Gross University of Rochester
Phillip G. Nelson
Phillip G. Nelson National Institutes of Health
Jeffery L. Barker
Jeffery L. Barker National Institutes of Health
Jaideep Kapur
Jaideep Kapur University of Virginia
Gregory K. Bergey
Gregory K. Bergey Johns Hopkins University School of Medicine
Michael A. Rogawski
Michael A. Rogawski University of California, Davis
Michael Browning
Michael Browning University of Oxford
Anthony P. King
Anthony P. King The Ohio State University
Anne B. Young
Anne B. Young Harvard University
Leanne M. Dibbens
Leanne M. Dibbens University of South Australia

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