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Chemistry

D-Index
47
Citations
8062
World Ranking
15638
National Ranking
865

Overview

Jim A. Thomas is affiliated with the University of Sheffield in the United Kingdom. Their research spans several interconnected fields primarily within Biochemistry, Genetics, and Molecular Biology, with significant contributions in Medicine.

The main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

They have further specialized in subfields such as:

  • Molecular Biology
  • Materials Chemistry
  • Oncology
  • Organic Chemistry
  • Biomedical Engineering

Their research focuses on various advanced topics, including:

  • Metal complexes synthesis and properties
  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • Nanoplatforms for cancer theranostics
  • Photodynamic Therapy Research Studies
  • Click Chemistry and Applications
  • Advanced Fluorescence Microscopy Techniques

Jim A. Thomas has published extensively in diverse high-profile scientific venues with the most frequent publication platforms being:

  • Chemical Science
  • Journal of the American Chemical Society
  • Dalton Transactions
  • Chemistry - A European Journal
  • The Cambridge Structural Database

Their recent papers include:

  • "A Dinuclear Ruthenium(II) Complex Excited by Near-Infrared Light through Two-Photon Absorption Induces Phototoxicity Deep within Hypoxic Regions of Melanoma Cancer Spheroids" (2020), Journal of the American Chemical Society
  • "Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics" (2020), Chemical Communications
  • "Mononuclear ruthenium(ii) theranostic complexes that function as broad-spectrum antimicrobials in therapeutically resistant pathogens through interaction with DNA" (2020), Chemical Science
  • "Triazole-based osmium(ii) complexes displaying red/near-IR luminescence: antimicrobial activity and super-resolution imaging" (2020), Chemical Science
  • "A Dinuclear Osmium(II) Complex Near-Infrared Nanoscopy Probe for Nuclear DNA" (2021), Journal of the American Chemical Society

Frequent collaborators in their research include:

  • Simon D. Fairbanks
  • Sreejesh Sreedharan
  • Craig C. Robertson
  • Kirsty L. Smitten
  • Jorge Bernardino de la Serna

Best Publications

  • Kinetically inert transition metal complexes that reversibly bind to DNA

    Clive Metcalfe;Jim A. Thomas

  • Ruthenium(II) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

    Martin R. Gill;Jim A. Thomas

  • A ruthenium( II ) polypyridyl complex for direct imaging of DNA structure in living cells

    Martin R. Gill;Jorge Garcia-Lara;Simon J. Foster;Carl Smythe

  • Dinuclear monointercalating RuII complexes that display high affinity binding to duplex and quadruplex DNA.

    Chatna Rajput;Ramune Rutkaite;Linda Swanson;Ihtshamul Haq

  • Dinuclear Ruthenium( II) Complexes as Two- Photon, Time- Resolved Emission Microscopy Probes for Cellular DNA

    Elizabeth Baggaley;Martin R. Gill;Nicola H. Green;David Turton

  • Optical imaging probes for biomolecules: an introductory perspective

    Jim A. Thomas

  • Targeting the endoplasmic reticulum with a membrane-interactive luminescent ruthenium(II) polypyridyl complex

    Martin R. Gill;Denis Cecchin;Michael G. Walker;Raminder S. Mulla

  • A Dinuclear Ruthenium(II) Complex Excited by Near-Infrared Light through Two-Photon Absorption Induces Phototoxicity Deep within Hypoxic Regions of Melanoma Cancer Spheroids.

    Ahtasham Raza;Stuart A Archer;Simon D Fairbanks;Kirsty L Smitten

  • Structural Studies on Dinuclear Ruthenium(II) Complexes That Bind Diastereoselectively to an Antiparallel Folded Human Telomere Sequence

    Tom Wilson;Paulo J. Costa;Vítor Félix;Mike P. Williamson

  • Ruthenium(II) Metallo-intercalators: DNA Imaging and Cytotoxicity

    Martin R. Gill;Hanan Derrat;Carl G. W. Smythe;Giuseppe Battaglia

  • A Multifunctional Light Switch: DNA Binding and Cleavage Properties of a Heterobimetallic Ruthenium–Rhenium Dipyridophenazine Complex†

    Simon P. Foxon;Tim Phillips;Martin R. Gill;Michael Towrie

  • Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit.

    Simon P. Foxon;Clive Metcalfe;Harry Adams;Michelle Webb

  • Extended terpyridyl and triazine complexes of d6-metal centres

    Clive Metcalfe;Sharon Spey;Harry Adams;Jim A. Thomas

  • Multimodal Super-resolution Optical Microscopy Using a Transition-Metal-Based Probe Provides Unprecedented Capabilities for Imaging Both Nuclear Chromatin and Mitochondria

    Sreejesh Sreedharan;Martin Gill;Esther Garcia;Hiwa K. Saeed

  • Photophysical properties and singlet oxygen production by ruthenium(II) complexes of benzo[i]dipyrido[3,2-a:2',3'-c]phenazine: spectroscopic and TD-DFT study

    Simon P. Foxon;Mohammed A. H. Alamiry;Mike G. Walker;Anthony J. H. M. Meijer

  • Locking self-assembly: strategies and outcomes

    Jim A. Thomas

  • Self-assembly of a supramolecular cube

    Sue Roche;Claire Haslam;Sarah L. Heath;Jim A. Thomas

  • Stereoisomerically controlled inorganic architectures: synthesis of enantio- and diastereo-merically pure ruthenium–palladium molecular rods from enantiopure building blocks

    Kenneth Wärnmark;Jim A. Thomas;Olga Heyke;Jean-Marie Lehn

  • Metal ion directed self-assembly of sensors for ions, molecules and biomolecules

    Jim A. Thomas

  • Studies on the interaction of extended terpyridyl and triazine metal complexes with DNA.

    Clive Metcalfe;Chatna Rajput;Jim A. Thomas

  • DNA binding of an organic dppz-based intercalator.

    Tim Phillips;Ihtshamul Haq;Anthony J. H. M. Meijer;Harry Adams

  • Differentiating quadruplexes: binding preferences of a luminescent dinuclear ruthenium(II) complex with four-stranded DNA structures.

    Tom Wilson;Mike P. Williamson;Jim A Thomas

Frequent Co-Authors

Harry Adams
Harry Adams University of Sheffield
Amitava Das
Amitava Das Indian Institute of Science Education and Research Kolkata
Vítor Félix
Vítor Félix University of Aveiro
John W. Haycock
John W. Haycock University of Sheffield
Miguel Julve
Miguel Julve University of Valencia
Giuseppe Battaglia
Giuseppe Battaglia Institute for Bioengineering of Catalonia
Michael P. Williamson
Michael P. Williamson University of Sheffield
Michael D. Ward
Michael D. Ward New York University
Sheila MacNeil
Sheila MacNeil University of Sheffield
Francesc Lloret
Francesc Lloret University of Valencia

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