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Biology and Biochemistry

D-Index
56
Citations
15264
World Ranking
14222
National Ranking
547

Overview

Gilles Divita is affiliated with the Centre national de la recherche scientifique (CNRS) in France, engaging in research primarily within the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work spans several subfields including Molecular Biology, Oncology, Biotechnology, and Radiology, Nuclear Medicine and Imaging.

The scientist's research topics are focused on:

  • CRISPR and Genetic Engineering
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • CAR-T cell therapy research
  • RNA modifications and cancer
  • Cancer-related Molecular Pathways
  • Cancer Research and Treatments

Gilles Divita has contributed to a number of recent research papers that reflect ongoing work in gene editing, cancer therapy, and molecular delivery systems. Notable publications include:

  • Enhanced CRISPR-Cas9 RNA system delivery using cell penetrating peptides-based nanoparticles for efficient in vitro and in vivo applications, 2024, Journal of Controlled Release
  • Abstract 1826: CRISPR mediated KRAS mutant gene editing in pancreatic and colorectal cancer therapy, 2020, Cancer Research
  • Abstract 550: p53 rescue of tumor suppressor function with ADGN-531 causes tumor regression both as single agent and in combination with PARPi and KRASG12C inhibitors, 2023, Cancer Research
  • Abstract 1717: KRAS mutant gene editing prevents tumor growth in vivo and overcomes acquired resistance to KRASG12C inhibitor, 2023, Cancer Research
  • Abstract 7236: Selective deletion of the KRAS mutant gene with ADGN-123 and ADGN-121 peptide-RNA nanoparticles: A new strategy to overcome acquired resistance to KRASG12C and KRASG12D small molecule inhibitors, 2024, Cancer Research

Publications are predominantly found in the journal Cancer Research, with seven articles, along with one article published in the Journal of Controlled Release.

Frequent collaborators in their research include Audrey Grunenberger, Véronique Josserand, Elodie Czuba, Mélanie Guidetti, and Neil Desai, each contributing to multiple joint publications. This indicates a collaborative approach across molecular biology and cancer research topics.

Best Publications

  • A peptide carrier for the delivery of biologically active proteins into mammalian cells.

    May C. Morris;Julien Depollier;Jean Mery;Frederic Heitz

  • Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

    Frederic Heitz;May Catherine Morris;Gilles Divita

  • A new peptide vector for efficient delivery of oligonucleotides into mammalian cells

    M. C. Morris;P. Vidal;L. Chaloin;F. Heitz

  • Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells

    Federica Simeoni;May C. Morris;Frederic Heitz;Gilles Divita

  • Cell-penetrating peptides: tools for intracellular delivery of therapeutics.

    S. Deshayes;M. C. Morris;G. Divita;F. Heitz

  • Cell-penetrating peptides: from molecular mechanisms to therapeutics.

    May C. Morris;Sebastien Deshayes;Frederic Heitz;Gilles Divita

  • A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells

    Laurence Crombez;Gudrun Aldrian-Herrada;Karidia Konate;Quan N Nguyen

  • UBA domains of DNA damage-inducible proteins interact with ubiquitin.

    Bonnie L. Bertolaet;Duncan J. Clarke;Meira Wolff;Mark H. Watson

  • Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I

    Ferdinand Rossi;Emmanuel Labourier;Thierry Forné;Gilles Divita

  • New Basic Membrane-Destabilizing Peptides for Plasmid-Based Gene Delivery in Vitro and in Vivo

    Karola Rittner;Annie Benavente;Albine Bompard-Sorlet;Frédéric Heitz

  • Secondary structure of cell-penetrating peptides controls membrane interaction and insertion.

    Emelía Eiríksdóttir;Karidia Konate;Ülo Langel;Ülo Langel;Gilles Divita

  • Effects of Phosphorylation of Threonine 160 on Cyclin-dependent Kinase 2 Structure and Activity

    Nicholas R. Brown;Martin E.M. Noble;Alison M. Lawrie;May C. Morris

  • Insight into the mechanism of internalization of the cell-penetrating carrier peptide Pep-1 through conformational analysis.

    Sébastien Deshayes;Annie Heitz;May C. Morris;Pierre Charnet

  • Delivery of proteins and nucleic acids using a non-covalent peptide-based strategy.

    Sébastien Deshayes;May Morris;Frédéric Heitz;Gilles Divita

  • A novel potent strategy for gene delivery using a single peptide vector as a carrier.

    May C. Morris;Laurent Chaloin;Jean Méry;Frederic Heitz

  • Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth.

    Laurence Crombez;May Catherine Morris;Sandrine Dufort;Gudrun Aldrian-Herrada

  • Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

    Katrin Rittinger;Gilles Divita;Roger S. Goody

  • A non-covalent peptide-based strategy for protein and peptide nucleic acid transduction.

    Edwige Gros;Sebastien Deshayes;May C. Morris;Gudrun Aldrian-Herrada

  • Design of Carrier Peptide-Oligonucleotide Conjugates with Rapid Membrane Translocation and Nuclear Localization Properties

    L. Chaloin;P. Vidal;Philippe Lory;J. Mery

  • Translocating peptides and proteins and their use for gene delivery.

    May C Morris;Laurent Chaloin;Frederic Heitz;Gilles Divita

Frequent Co-Authors

Frédéric Heitz
Frédéric Heitz Centre national de la recherche scientifique, CNRS
Roger S. Goody
Roger S. Goody Max Planck Society
Jamal Tazi
Jamal Tazi University of Montpellier
Yves Mély
Yves Mély University of Strasbourg
John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Jean-Luc Coll
Jean-Luc Coll Grenoble Alpes University
Catherine Dargemont
Catherine Dargemont Université Paris Cité
Attilio Di Pietro
Attilio Di Pietro University of Lyon System
Louise N. Johnson
Louise N. Johnson University of Oxford

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