2026 Holger Wille: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	54	15519	14249	543	499	129	12117

Overview

Holger Wille is affiliated with the University of Alberta in Canada, focusing research predominantly on biochemistry, genetics, and molecular biology, with additional work in medicine.

The scientist's main fields of study include:

Biochemistry, Genetics and Molecular Biology
Medicine

Subfields explored encompass:

Molecular Biology
Physiology
Neurology
Nutrition and Dietetics
Pharmacology

The research topics investigated cover various neurological and molecular conditions including:

Alzheimer's disease research and treatments
Prion Diseases and Protein Misfolding
Trace Elements in Health
Neurological diseases and metabolism
Cholinesterase and Neurodegenerative Diseases
Supramolecular Self-Assembly in Materials
Parkinson's Disease Mechanisms and Treatments

Frequent publication venues where the scientist's work appears include:

bioRxiv (Cold Spring Harbor Laboratory)
PLoS Pathogens
Scientific Reports
Bioactive Materials
Brain

Co-authors regularly collaborating with Holger Wille are:

Sara Amidian
Leonardo M. Cortez
Valerie L. Sim
Maria Stepanova
Satyabrata Kar

Recent papers authored or co-authored by Holger Wille include:

"Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints" (2020), published in Nucleic Acids Research
"Significance of native PLGA nanoparticles in the treatment of Alzheimer's disease pathology" (2022), published in Bioactive Materials
"Unconjugated PLGA nanoparticles attenuate temperature-dependent β-amyloid aggregation and protect neurons against toxicity: implications for Alzheimer's disease pathology" (2022), published in Journal of Nanobiotechnology
"Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity" (2021), published in Bioactive Materials
"Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers" (2020), published in Nanoscale

Best Publications

Eight prion strains have PrP Sc molecules with different conformations

Jiri Safar;Holger Wille;Vincenza Itri;Darlene Groth

1532
Citations
Evidence for assembly of prions with left-handed β-helices into trimers

Cédric Govaerts;Holger Wille;Stanley B. Prusiner;Fred E. Cohen

724
Citations
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

Martin Vey;Susanne Pilkuhn;Holger Wille;Randal Nixon

693
Citations
Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro.

H Wille;G Drewes;J Biernat;E M Mandelkow

595
Citations
Structural studies of the scrapie prion protein by electron crystallography

Holger Wille;Melissa D. Michelitsch;Vincent Guénebaut;Surachai Supattapone

526
Citations
Small-molecule aggregates inhibit amyloid polymerization

Brian Y Feng;Brandon H Toyama;Holger Wille;David W Colby

300
Citations
Branched Polyamines Cure Prion-Infected Neuroblastoma Cells

Surachai Supattapone;Holger Wille;Lisa Uyechi;Jiri Safar

293
Citations
Design and construction of diverse mammalian prion strains.

David W. Colby;Kurt Giles;Giuseppe Legname;Holger Wille

266
Citations
Natural and synthetic prion structure from X-ray fiber diffraction

Holger Wille;Wen Bian;Michele McDonald;Amy Kendall

261
Citations
Cytosolic Prion Protein in Neurons

Alexander Mironov;Diane Latawiec;Holger Wille;Essia Bouzamondo-Bernstein

260
Citations
Prion Protein of 106 Residues Creates an Artificial Transmission Barrier for Prion Replication in Transgenic Mice

Surachai Supattapone;Patrick Bosque;Tamaki Muramoto;Holger Wille

257
Citations
Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change

Bess Frost;Julian Ollesch;Holger Wille;Marc I. Diamond

254
Citations
α-Synuclein strains target distinct brain regions and cell types

Angus Lau;Raphaella W. L. So;Heather H. C. Lau;Jason C. Sang

238
Citations
Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation.

T Hagestedt;B Lichtenberg;H Wille;E M Mandelkow

235
Citations
Engineering a 2D Protein–DNA Crystal

Jonathan Malo;James C. Mitchell;Catherine Vénien-Bryan;J. Robin Harris

211
Citations
Mechanisms of prion protein assembly into amyloid.

Jan Stöhr;Nicole Weinmann;Holger Wille;Tina Kaimann

172
Citations
A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice.

Kiyotoshi Kaneko;Haydn L. Ball;Holger Wille;Hong Zhang

167
Citations
The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.

Ester Vázquez-Fernández;Matthijn R. Vos;Pavel Afanasyev;Lino Cebey

160
Citations
Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity.

D Riesner;K Kellings;K Post;H Wille

151
Citations
Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters

Gerold Schmitt-Ulms;Sepehr Ehsani;Joel C. Watts;Joel C. Watts;David Westaway

150
Citations