Fred E. Cohen

Overview

Best Publications

• Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

  K M Pan;M Baldwin;J Nguyen;M Gasset

  3119
  Citations

• Eight prion strains have PrP Sc molecules with different conformations

  Jiri Safar;Holger Wille;Vincenza Itri;Darlene Groth

  1532
  Citations

• An evolutionary trace method defines binding surfaces common to protein families

  Olivier Lichtarge;Henry R. Bourne;Fred E. Cohen

  1504
  Citations

• Synthetic Mammalian Prions

  Giuseppe Legname;Ilia V. Baskakov;Hoang-Oanh B. Nguyen;Detlev Riesner

  1295
  Citations

• Prion protein biology.

  Stanley B Prusiner;Michael R Scott;Stephen J DeArmond;Fred E Cohen

  1255
  Citations

• Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

  Glenn C. Telling;Michael Scott;James Mastrianni;Ruth Gabizon

  1113
  Citations

• Bayesian statistical analysis of protein side-chain rotamer preferences

  Roland L. Dunbrack;Fred E. Cohen

  1042
  Citations

• Therapeutic approaches to protein-misfolding diseases

  Fred E. Cohen;Jeffery W. Kelly

  1035
  Citations

• Improvements in protein secondary structure prediction by an enhanced neural network

  D.G. Kneller;F.E. Cohen;R. Langridge

  941
  Citations

• Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible.

  Donne Dg;Viles Jh;Groth D;Mehlhorn I

  878
  Citations

• Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

  Carsten Korth;Barnaby C. H. May;Fred E. Cohen;Stanley B. Prusiner

  862
  Citations

• Evidence for assembly of prions with left-handed β-helices into trimers

  Cédric Govaerts;Holger Wille;Stanley B. Prusiner;Fred E. Cohen

  724
  Citations

• PREDICTION OF PROTEIN SIDE-CHAIN ROTAMERS FROM A BACKBONE-DEPENDENT ROTAMER LIBRARY : A NEW HOMOLOGY MODELING TOOL

  Michael J. Bower;Fred E. Cohen;Roland L. Dunbrack

  716
  Citations

• Pathologic Conformations of Prion Proteins

  Fred E. Cohen;Stanley B. Prusiner

  709
  Citations

• Structural clues to prion replication

  Fred E. Cohen;Keh-Ming Pan;Ziwei Huang;Michael Baldwin

  705
  Citations

• COPPER BINDING TO THE PRION PROTEIN : STRUCTURAL IMPLICATIONS OF FOUR IDENTICAL COOPERATIVE BINDING SITES

  John H. Viles;Fred E. Cohen;Stanley B. Prusiner;David B. Goodin

  702
  Citations

• Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

  Kiyotoshi Kaneko;Laurence Zulianello;Michael Scott;Carol M. Cooper

  702
  Citations

• Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.

  R. C. Moore;I. Y. Lee;G. L. Silverman;P. M. Harrison

  700
  Citations

• Prion protein selectively binds copper(II) ions.

  Johannes Stöckel;Jiri Safar;Andrew C. Wallace;Fred E. Cohen

  660
  Citations

• Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.

  Thomas L. James;He Liu;Nikolai B. Ulyanov;Shauna Farr-Jones

  609
  Citations