Darlene Groth

Overview

Best Publications

• Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

  K M Pan;M Baldwin;J Nguyen;M Gasset

  3119
  Citations

• Eight prion strains have PrP Sc molecules with different conformations

  Jiri Safar;Holger Wille;Vincenza Itri;Darlene Groth

  1532
  Citations

• Scrapie prions aggregate to form amyloid-like birefringent rods

  Stanley B. Prusiner;Michael P. McKinley;Karen A. Bowman;David C. Bolton

  1511
  Citations

• Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

  K. Basler;B. Oesch;M. Scott;D. Westaway

  1164
  Citations

• Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

  Stanley B. Prusiner;Michael Scott;Dallas Foster;Keh-Ming Pan

  1128
  Citations

• Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

  Michael Scott;Dallas Foster;Carol Mirenda;Dan Serban

  939
  Citations

• Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible.

  Donne Dg;Viles Jh;Groth D;Mehlhorn I

  878
  Citations

• Spontaneous neurodegeneration in transgenic mice with mutant prion protein.

  Karen K. Hsiao;Michael Scott;Dallas Foster;Darlene F. Groth

  730
  Citations

• Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies

  Stanley B. Prusiner;Darlene Groth;Ana Serban;Ruth Koehler

  698
  Citations

• Purification and structural studies of a major scrapie prion protein

  Stanley B. Prusiner;Darlene F. Groth;David C. Bolton;Stephen B. Kent

  659
  Citations

• Further purification and characterization of scrapie prions

  S B Prusiner;D C Bolton;D F Groth;K A Bowman

  641
  Citations

• Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.

  Thomas L. James;He Liu;Nikolai B. Ulyanov;Shauna Farr-Jones

  609
  Citations

• Measurement of the scrapie agent using an incubation time interval assay

  Stanley B. Prusiner;S. Patricia Cochran;Darlene F. Groth;Deborah E. Downey

  494
  Citations

• Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes.

  Michael Scott;Darlene Groth;Dallas Foster;Marilyn Torchia

  465
  Citations

• Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein.

  Tamao Endo;Darlene Groth;Stanley B. Prusiner;Akira Kobata

  424
  Citations

• Transmissible and genetic prion diseases share a common pathway of neurodegeneration

  Ramanujan S. Hegde;Patrick Tremblay;Darlene Groth;Stephen J. DeArmond

  419
  Citations

• Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins.

  David Westaway;Stephen J. DeArmond;Juliana Cayetano-Canlas;Darlene Groth

  418
  Citations

• Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein

  Karen K. Hsiao;Darlene Groth;Michael Scott;Shu Lian Yang

  391
  Citations

• Glycosylation differences between the normal and pathogenic prion protein isoforms.

  Pauline M. Rudd;Tama Endo;Cristina Colominas;Darlene Groth

  376
  Citations

• Asparagine-linked glycosylation of the scrapie and cellular prion proteins.

  Tokuko Haraguchi;Susan Fisher;Sigvard Olofsson;Tamao Endo

  371
  Citations