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Chemistry

D-Index
40
Citations
6281
World Ranking
17884
National Ranking
977

Overview

Nicholas H. Williams is a researcher affiliated with the University of Sheffield in the United Kingdom. Their body of work spans multiple disciplines within engineering, with notable contributions to molecular biology, materials chemistry, biomedical engineering, organic chemistry, and mechanics of materials.

Their research focuses on several main topics including crystallization and solubility studies, X-ray diffraction in crystallography, flow measurement and analysis, water systems and optimization, metal-organic frameworks synthesis and applications, supramolecular chemistry and complexes, and molecular sensors and ion detection.

Recent publications by Nicholas H. Williams include the following:

  • Interaction of anions with the surface of a coordination cage in aqueous solution probed by their effect on a cage-catalysed Kemp elimination, 2021, Chemical Science
  • Modeling the Alkaline Hydrolysis of Diaryl Sulfate Diesters: A Mechanistic Study, 2020, The Journal of Organic Chemistry
  • Adhesion between oppositely charged polyelectrolytes in salt solution, 2020, Journal of Applied Polymer Science
  • Transmembrane signal transduction by cofactor transport, 2021, Chemical Science
  • Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O6-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O6-Alkylguanine Adductome, 2023, Chemical Research in Toxicology

They frequently collaborate with several co-authors, including:

  • Christopher G. P. Taylor
  • Alexander J. Metherell
  • Stephen P. Argent
  • Fatma M. Ashour
  • Michael D. Ward

Nicholas H. Williams has published work in a variety of venues, most notably:

  • The Cambridge Structural Database
  • Chemical Science
  • Swinburne Research Bank (Swinburne University of Technology)
  • arXiv (Cornell University)
  • Foot & Ankle Orthopaedics

Their expertise is primarily situated within the engineering domain, supplemented by interdisciplinary applications that cover molecular biology and materials chemistry. The range of their work incorporates both theoretical modeling and practical experimental approaches in topics such as crystallography and chemical interactions in solution.

Best Publications

  • Structure and Nuclease Activity of Simple Dinuclear Metal Complexes: Quantitative Dissection of the Role of Metal Ions

    Nicholas H. Williams;Bryan Takasaki;Mark Wall;Jik Chin

  • Highly efficient catalysis of the Kemp elimination in the cavity of a cubic coordination cage

    William Cullen;M. Cristina Misuraca;Christopher A. Hunter;Nicholas H. Williams

  • The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases.

    Chetan Lad;Nicholas H. Williams;Richard Wolfenden

  • The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA

    Gottfried K. Schroeder;Chetan Lad;Paul Wyman;Nicholas H. Williams

  • Coordination Cages Based on Bis(pyrazolylpyridine) Ligands: Structures, Dynamic Behavior, Guest Binding, and Catalysis

    Michael D. Ward;Christopher A. Hunter;Nicholas H. Williams

  • Comparing a mononuclear Zn(II) complex with hydrogen bond donors with a dinuclear Zn(II) complex for catalysing phosphate ester cleavage.

    Guoqiang Feng;Juan C. Mareque-Rivas;Nicholas H. Williams

  • Efficient Phosphodiester Binding and Cleavage by a ZnII Complex Combining Hydrogen‐Bonding Interactions and Double Lewis Acid Activation

    Guoqiang Feng;Daniela Natale;Ravi Prabaharan;Juan C. Mareque-Rivas

  • A highly reactive mononuclear Zn(II) complex for phosphodiester cleavage.

    Guoqiang Feng;Juan C. Mareque-Rivas;R. Torres Martín de Rosales;Nicholas H. Williams

  • Reactivity of Phosphate Diesters Doubly Coordinated to a Dinuclear Cobalt(III) Complex: Dependence of the Reactivity on the Basicity of the Leaving Group

    Nicholas H. Williams;William Cheung;Jik Chin

  • Catalysis in a cationic coordination cage using a cavity-bound guest and surface-bound anions : inhibition, activation, and autocatalysis

    William Cullen;Alexander J. Metherell;Ashley B. Wragg;Christopher G. P. Taylor

  • Enterprise and public and policy: a review of Labour Government intervention in the United Kingdom

    Robert Huggins;Nicholas Williams

  • Cooperative binding at lipid bilayer membrane surfaces.

    Emma L. Doyle;Christopher A. Hunter;Helen C. Phillips;Simon J. Webb

  • Resolving apparent conflicts between theoretical and experimental models of phosphate monoester hydrolysis.

    Fernanda Duarte;Johan Åqvist;Nicholas H Williams;Shina C Lynn Kamerlin

  • A Structural and Functional Model of Dinuclear Metallophosphatases

    Nicholas H. Williams;‡ and Anne-Marie Lebuis;Jik Chin

  • Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.

    Nicola J Baxter;G Michael Blackburn;James P Marston;Andrea M Hounslow

  • Controlled membrane translocation provides a mechanism for signal transduction and amplification

    Matthew J. Langton;Flore Keymeulen;Maria Ciaccia;Nicholas H. Williams

  • Cleavage and isomerization of UpU promoted by dinuclear metal ion complexes.

    Heidi Linjalahti;Guoqiang Feng;Juan C. Mareque-Rivas;Satu Mikkola

  • An altered mechanism of hydrolysis for a metal-complexed phosphate diester.

    Tim Humphry;Marcello Forconi;Nicholas H. Williams;Alvan C. Hengge

  • Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF 3 - rather than by phosphoranes

    Nicola J. Baxter;Matthew W. Bowler;Tooba Alizadeh;Matthew J. Cliff

  • A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

    Nicola J Baxter;Luis F Olguin;Marko Golicnik;Guoqiang Feng

Frequent Co-Authors

Alvan C. Hengge
Alvan C. Hengge Utah State University
Christopher A. Hunter
Christopher A. Hunter University of Pennsylvania
Michael D. Ward
Michael D. Ward New York University
Guoqiang Feng
Guoqiang Feng Central China Normal University
Jonathan P. Waltho
Jonathan P. Waltho University of Sheffield
Anthony J. Kirby
Anthony J. Kirby University of Cambridge
Jik Chin
Jik Chin University of Toronto
John W. Haycock
John W. Haycock University of Sheffield
Graham J. Leggett
Graham J. Leggett University of Sheffield
John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center

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