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Chemistry

D-Index
52
Citations
9987
World Ranking
13479
National Ranking
3527

Overview

Jonathan L. Vennerstrom is affiliated with the University of Nebraska Medical Center in the United States. Their research spans multiple fields including Medicine and Materials Science, with a particular focus on Materials Chemistry and Public Health, Environmental and Occupational Health.

The scientist's work concentrates on a range of topics centered on crystallization and solubility studies, X-ray diffraction in crystallography, and parasite-host interactions. Specific areas of research include malaria and helminth infection control, leishmaniasis studies, and computational methods for drug discovery.

Frequent co-authors contributing to their research output include Yuxiang Dong, Derek A. Leas, Susan A. Charman, Jered C. Garrison, and Edward L. Ezell.

Publications by Jonathan L. Vennerstrom appear predominantly in venues such as The Cambridge Structural Database, ACS Infectious Diseases, Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry, and Figshare.

Significant recent papers authored or co-authored by Vennerstrom include:

  • Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells, 2022, ACS Infectious Diseases
  • Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus, 2022, Science Translational Medicine
  • Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids, 2020, Journal of Medicinal Chemistry
  • Ligand-based design of GLUT inhibitors as potential antitumor agents, 2020, Bioorganic & Medicinal Chemistry
  • Virtual screening and biological evaluation of PPARγ antagonists as potential anti-prostate cancer agents, 2021, Bioorganic & Medicinal Chemistry

Best Publications

  • Oxidative stress in malaria parasite-infected erythrocytes: Host-parasite interactions

    Katja Becker;Leann Tilley;Jonathan L. Vennerstrom;David Roberts

  • Identification of an antimalarial synthetic trioxolane drug development candidate.

    Jonathan L Vennerstrom;Sarah Arbe-Barnes;Reto Brun;Susan A Charman

  • An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials

    Arnulf Dorn;Sudha Rani Vippagunta;Hugues Matile;Catherine Jaquet

  • Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines.

    J L Vennerstrom;M T Makler;C K Angerhofer;J A Williams

  • Synthetic peroxides as antimalarials

    Unknown

  • In Vitro and In Vivo Activities of Synthetic Trioxolanes against Major Human Schistosome Species

    Shu Hua Xiao;Jennifer Keiser;Jacques Chollet;Jürg Utzinger

  • Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.

    Jonathan L. Vennerstrom;Hong Ning Fu;William Y. Ellis;Arba L. Ager

  • Artemisinin-resistant malaria: research challenges, opportunities, and public health implications.

    Rick M. Fairhurst;Gaurvika M. L. Nayyar;Joel G. Breman;Rachel Hallett

  • Oxidants, Oxidant Drugs, and Malaria

    Jonathan L. Vennerstrom;John W. Eaton

  • Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.

    Sudha Rani Vippagunta;Arnulf Dorn;Hugues Matile;Apurba K. Bhattacharjee

  • Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria

    Jonathan L. Vennerstrom;William Y. Ellis;William Y. Ellis;William Y. Ellis;Arba L. Ager;Arba L. Ager;Arba L. Ager;Steven L. Andersen;Steven L. Andersen;Steven L. Andersen

  • First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

    Joerg J. Moehrle;Stephan Duparc;Christoph Siethoff;Paul L. M. van Giersbergen

  • Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity

    James C Burnett;James J Schmidt;Robert G Stafford;Rekha G Panchal

  • Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

    Yuxiang Dong;Jacques Chollet;Hugues Matile;Susan A Charman

  • Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

    Darren John Creek;William Neil Charman;Francis Chi Keung Chiu;Richard John Prankerd

  • A Comparison and Analysis of Several Ways to Promote Haematin (Haem) Polymerisation and an Assessment of Its Initiation In Vitro

    Arnulf Dorn;Sudha Rani Vippagunta;Hugues Matile;André Bubendorf

  • 8-Aminoquinolines Active against Blood Stage Plasmodium falciparum In Vitro Inhibit Hematin Polymerization

    Jonathan L. Vennerstrom;Edwin O. Nuzum;Robert E. Miller;Arnulf Dorn

  • Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups

    Yuxiang Dong;Hugues Matile;Jacques Chollet;Ronald Kaminsky

  • Clinically Available Medicines Demonstrating Anti-Toxoplasma Activity

    Andrew J. Neville;Sydney J. Zach;Xiaofang Wang;Joshua J. Larson

  • The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

    Yuxiang Dong;Sergio Wittlin;Kamaraj Sriraghavan;Jacques Chollet

  • Dispiro-1,2,4-trioxane Analogues of a Prototype Dispiro-1,2,4-trioxolane: Mechanistic Comparators for Artemisinin in the Context of Reaction Pathways with Iron(II)

    Yuanqing Tang;Yuxiang Dong;Xiaofang Wang;Kamaraj Sriraghavan

  • Synthesis of tetrasubstituted ozonides by the Griesbaum coozonolysis reaction: diastereoselectivity and functional group transformations by post-ozonolysis reactions.

    Yuanqing Tang;Yuxiang Dong;Jean M. Karle;Charles A. DiTusa

  • Dispiro‐1,2,4,5‐tetraoxanes: A New Class of Antimalarial Peroxides.

    J. L. Vennerstrom;H.‐N. Fu;W. Y. Ellis;A. L. Jun. Ager

Frequent Co-Authors

Sergio Wittlin
Sergio Wittlin Swiss Tropical and Public Health Institute
Susan A. Charman
Susan A. Charman Monash University
Hugues Matile
Hugues Matile Roche (Switzerland)
Wilbur K. Milhous
Wilbur K. Milhous Clemson University
Reto Brun
Reto Brun University of Basel
Sina Bavari
Sina Bavari United States Army Medical Research Institute of Infectious Diseases
Marcel Kaiser
Marcel Kaiser Swiss Tropical and Public Health Institute
Pascal Mäser
Pascal Mäser Swiss Tropical and Public Health Institute
Pascal Ringwald
Pascal Ringwald World Health Organization
Christopher V. Plowe
Christopher V. Plowe University of Maryland, Baltimore

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