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D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
11094
World Ranking
13891
National Ranking
252

Overview

Hugues Matile is affiliated with Roche in Switzerland and conducts research primarily in the fields of Medicine, Pharmacology, Toxicology and Pharmaceutics, and Computer Science. Their work spans various subfields including Public Health, Environmental and Occupational Health, Pharmacology, and Computational Theory and Mathematics.

Their research encompasses multiple topics, with a particular focus on Malaria Research and Control, Pharmacogenetics and Drug Metabolism, and Computational Drug Discovery Methods. This interdisciplinary approach combines aspects of health sciences with computational methodologies.

Matile has contributed to scientific literature with publications in venues such as ACS Infectious Diseases. One of their recent papers is titled "Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439", published in 2021 in ACS Infectious Diseases.

  • David M. Shackleford
  • Francis C. K. Chiu
  • Kasiram Katneni
  • Scott Blundell
  • Jenna McLaren

The frequent coauthors listed alongside Matile include David M. Shackleford, Francis C. K. Chiu, Kasiram Katneni, Scott Blundell, and Jenna McLaren. These collaborations underline Matile's engagement with diverse researchers within the biomedical and computational sciences.

  • ACS Infectious Diseases

Matile's interdisciplinary expertise and collaboration network reflect a focus on integrating knowledge from pharmacology, medicine, and computational science to address challenges in drug metabolism and disease control.

Best Publications

  • Identification of an antimalarial synthetic trioxolane drug development candidate.

    Jonathan L Vennerstrom;Sarah Arbe-Barnes;Reto Brun;Susan A Charman

  • Structure of the µ-opioid receptor–G i protein complex

    Antoine Koehl;Hongli Hu;Shoji Maeda;Yan Zhang

  • A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules.

    F. Sinigaglia;M. Guttinger;J. Kilgus;D. M. Doran

  • Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein

    Arnulf Dorn;Ruedi Stoffel;Hugues Matile;André Bubendorf

  • Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

    Susan A. Charman;Sarah Arbe-Barnes;Ian C. Bathurst;Reto Brun

  • An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials

    Arnulf Dorn;Sudha Rani Vippagunta;Hugues Matile;Catherine Jaquet

  • System for High-Level Production in Escherichia coli and Rapid Purification of Recombinant Proteins: Application to Epitope Mapping, Preparation of Antibodies, and Structure—Function Analysis

    Dietrich Stüber;Hugues Matile;Gianni Garotta

  • 4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum.

    R G Ridley;W Hofheinz;H Matile;C Jaquet

  • A common mechanism for blockade of heme polymerization by antimalarial quinolines

    David J. Sullivan;Hugues Matile;Robert G. Ridley;Daniel E. Goldberg

  • Structure of the mu-opioid receptor-Giprotein complex.

    Antoine Koehl;Hongli Hu;Shoji Maeda;Yan Zhang

  • Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport.

    Eric J. Niesor;Christine Magg;Naoto Ogawa;Hiroshi Okamoto

  • Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.

    Sudha Rani Vippagunta;Arnulf Dorn;Hugues Matile;Apurba K. Bhattacharjee

  • Plasmodium Falciparum Malaria Parasite Cultures and Their Use in Immunology

    Hugues Matile;J. Richard;L. Pink

  • Development of an antibody fragment that stabilizes GPCR/G-protein complexes.

    Shoji Maeda;Antoine Koehl;Hugues Matile;Hongli Hu

  • Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.

    Daria Esterházy;Ina Stützer;Haiyan Wang;Markus P. Rechsteiner;Markus P. Rechsteiner

  • Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

    Yuxiang Dong;Jacques Chollet;Hugues Matile;Susan A Charman

  • A malaria heat-shock-like determinant expressed on the infected hepatocyte surface is the target of antibody-dependent cell-mediated cytotoxic mechanisms by nonparenchymal liver cells.

    Laurent Rénia;Denise Mattei;Joseph Goma;Sylviane Pied

  • Ability of recombinant or native proteins to protect monkeys against heterologous challenge with Plasmodium falciparum.

    H M Etlinger;P Caspers;H Matile;H J Schoenfeld

  • Inhibitory activity of interferons and interleukin 1 on the development of Plasmodium falciparum in human hepatocyte cultures.

    S Mellouk;R K Maheshwari;A Rhodes-Feuillette;R L Beaudoin

  • Expression and characterisation of plasmepsin I from Plasmodium falciparum.

    Richard P. Moon;Lorraine Tyas;Ulrich Certa;Katharina Rupp

Frequent Co-Authors

Sergio Wittlin
Sergio Wittlin Swiss Tropical and Public Health Institute
Gerd Pluschke
Gerd Pluschke Swiss Tropical and Public Health Institute
Jonathan L. Vennerstrom
Jonathan L. Vennerstrom University of Nebraska Medical Center
Reto Brun
Reto Brun University of Basel
Susan A. Charman
Susan A. Charman Monash University
Gebhard F. X. Schertler
Gebhard F. X. Schertler Paul Scherrer Institute
Ulrich Certa
Ulrich Certa Roche (Switzerland)
Francesco Sinigaglia
Francesco Sinigaglia Dompé (Italy)
Markus Stoffel
Markus Stoffel University of Geneva
Pascal Mäser
Pascal Mäser Swiss Tropical and Public Health Institute

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