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Biology and Biochemistry

D-Index
67
Citations
21789
World Ranking
8083
National Ranking
3660

Overview

Rebecca Taub is affiliated with Madrigal Pharmaceuticals in the United States, where their research focuses primarily on liver diseases and related metabolic conditions. Their body of work is situated within the field of Medicine, with a substantial contribution to subfields including Epidemiology, Hepatology, Endocrinology, Diabetes and Metabolism, Physiology, and Pulmonary and Respiratory Medicine.

Their research explores multiple main topics, notably:

  • Liver Disease Diagnosis and Treatment
  • Liver Diseases and Immunity
  • Diet and Metabolism Studies
  • Liver Disease and Transplantation
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Electrolyte and Hormonal Disorders
  • Drug Transport and Resistance Mechanisms

Rebecca Taub's recent scientific contributions include the following publications:

  • A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis (2024) published in New England Journal of Medicine
  • Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial (2023) published in Nature Medicine
  • Effects of Resmetirom on Noninvasive Endpoints in a 36-Week Phase 2 Active Treatment Extension Study in Patients With NASH (2021) published in Hepatology Communications
  • Hepatic Fat Reduction Due to Resmetirom in Patients With Nonalcoholic Steatohepatitis Is Associated With Improvement of Quality of Life (2021) published in Clinical Gastroenterology and Hepatology
  • Design of the phase 3 MAESTRO clinical program to evaluate resmetirom for the treatment of nonalcoholic steatohepatitis (2023) published in Alimentary Pharmacology & Therapeutics

The scientist frequently collaborates with peers in their field, including Dominic Labriola, Stephen A. Harrison, Jörn M. Schattenberg, Naim Alkhouri, and Rohit Loomba. These collaborations reflect a strong interdisciplinary approach in their work on liver diseases and metabolic conditions.

Rebecca Taub's research is regularly published in well-regarded venues such as:

  • Journal of Hepatology
  • Zeitschrift für Gastroenterologie
  • New England Journal of Medicine
  • Alimentary Pharmacology & Therapeutics
  • Digestive and Liver Disease

Through their publications and collaborations, Rebecca Taub contributes to understanding and advancing treatments in the field of hepatology and metabolic disorders, particularly focusing on nonalcoholic steatohepatitis (NASH) and related liver conditions.

Best Publications

  • Liver regeneration: from myth to mechanism

    Rebecca Taub;Rebecca Taub

  • Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

    Drew E. Cressman;Linda E. Greenbaum;Robert A. DeAngelis;Gennaro Ciliberto

  • Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells

    R Taub;I Kirsch;C Morton;G Lenoir

  • The human c-myc oncogene : Structural consequences of translocation into the IgH locus in Burkitt lymphoma

    Jim Battey;Christopher Moulding;Rebecca Taub;William Murphy

  • Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

    Stephen A Harrison;Stephen A Harrison;Mustafa R Bashir;Cynthia D Guy;Rong Zhou

  • Liver regeneration 4: transcriptional control of liver regeneration.

    Rebecca Taub

  • Rapid activation of the stat3 transcription complex in liver regeneration

    Drew E. Cressman;Robert H. Diamond;Rebecca Taub

  • PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth.

    R H Diamond;D E Cressman;T M Laz;C S Abrams

  • Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice.

    Kellen Kovalovich;Robert A. DeAngelis;Wei Li;Emma E. Furth

  • STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration.

    Wei Li;Xianping Liang;Christoph Kellendonk;Valeria Poli

  • The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy

    Franz M. Matschinsky;Mark A. Magnuson;Dorothy Zelent;Tom L. Jetton

  • CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy.

    Linda E. Greenbaum;Wei Li;Drew E. Cressman;Yong Peng

  • Interleukin-6 Protects against Fas-mediated Death by Establishing a Critical Level of Anti-apoptotic Hepatic Proteins FLIP, Bcl-2, and Bcl-xL*

    Kellen Kovalovich;Wei Li;Robert DeAngelis;Linda E. Greenbaum

  • A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen.

    R Taub;R J Gould;V M Garsky;T M Ciccarone

  • The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells: comparison with serum-stimulated 3T3 cells and identification of 41 novel immediate-early genes.

    K. L. Mohn;T. M. Laz;Jui-Chou Hsu;A. E. Melby

  • Rapid activation of post-hepatectomy factor/nuclear factor kappa B in hepatocytes, a primary response in the regenerating liver.

    D E Cressman;L E Greenbaum;B A Haber;R Taub

  • Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration.

    B A Haber;K L Mohn;R H Diamond;R Taub

  • Interactions Among LRF-1, JunB, c-Jun, and c-Fos Define a Regulatory Program in the G1 Phase of Liver Regeneration

    Jui-Chou Hsu;R. Bravo;R. Taub

  • Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation

    Håkan Persson;Lothar Hennighausen;Rebecca Taub;William DeGrado

  • Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex.

    M. Tewari;P. Dobrzanski;K. L. Mohn;D. E. Cressman

Frequent Co-Authors

Gennaro Ciliberto
Gennaro Ciliberto Magna Graecia University
Emma E. Furth
Emma E. Furth University of Pennsylvania
Kim M. Olthoff
Kim M. Olthoff University of Pennsylvania
Abraham Shaked
Abraham Shaked University of Pennsylvania
Valeria Poli
Valeria Poli University of Turin
James A. Hoxie
James A. Hoxie University of Pennsylvania
Brent A. Neuschwander-Tetri
Brent A. Neuschwander-Tetri Saint Louis University
Sanford J. Shattil
Sanford J. Shattil University of California, San Diego
Klaus H. Kaestner
Klaus H. Kaestner University of Pennsylvania
Nancy B. Spinner
Nancy B. Spinner Children's Hospital of Philadelphia

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