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Genetics

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84
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Medicine

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Overview

Marc Cruts is a researcher affiliated with the University of Antwerp in Belgium. Their work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Neurology, Physiology, Molecular Biology, and Aging.

The main research topics covered by Marc Cruts include:

  • Parkinson's Disease Mechanisms and Treatments
  • Neurological diseases and metabolism
  • Alzheimer's disease research and treatments
  • Amyotrophic Lateral Sclerosis Research
  • Epigenetics and DNA Methylation
  • Genetics, Aging, and Longevity in Model Organisms

Marc Cruts has contributed to publications in several noted academic venues, with the following journals featuring their recent papers:

  • Biological Psychiatry
  • Scientific Reports
  • Acta Neuropathologica

Their recent papers include:

  • "Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood," 2022, Biological Psychiatry
  • "Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis," 2020, Scientific Reports
  • "Correction to: Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins," 2024, Acta Neuropathologica

Throughout their career, Marc Cruts has frequently collaborated with several researchers, including:

  • Christine Van Broeckhoven
  • Raffaele Ferrari
  • Dena Hernandez
  • Michael A. Nalls
  • Jonathan D. Rohrer

Best Publications

  • NanoPack: visualizing and processing long-read sequencing data.

    Wouter De Coster;Svenn D’Hert;Darrin T Schultz;Marc Cruts

  • Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

    Marc Cruts;Ilse Gijselinck;Julie van der Zee;Sebastiaan Engelborghs

  • The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

    Kohji Mori;Shih-Ming Weng;Thomas Arzberger;Stephanie May

  • Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

    Lydia Hendriks;Cornelia M. van Duijn;Patrick Cras;Marc Cruts

  • A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study.

    Ilse Gijselinck;Tim Van Langenhove;Julie van der Zee;Kristel Sleegers

  • Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.

    Karen Nuytemans;Jessie Theuns;Marc Cruts;Christine Van Broeckhoven

  • Locus-Specific Mutation Databases for Neurodegenerative Brain Diseases

    Marc Cruts;Jessie Theuns;Christine Van Broeckhoven

  • Genetic association of apolipoprotein E with age-related macular degeneration

    Caroline C.W. Klaver;Mike Kliffen;Cornelia M. van Duijn;Albert Hofman

  • Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease

    C.M. van Duijn;P. de Knijff;M. Cruts;A. Wehnert;A. Wehnert

  • Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins

    Kohji Mori;Thomas Arzberger;Thomas Arzberger;Friedrich A. Grässer;Ilse Gijselinck

  • Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

    Marc Cruts;Cornelia M. van Duijn;Hubert Backhovens;Marleen Van den Broeck

  • Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study.

    Arjen J. C. Slooter;Marc Cruts;Sandra Kalmijn;Albert Hofman

  • APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.

    Kristel Sleegers;Nathalie Brouwers;Ilse Gijselinck;Jessie Theuns

  • Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40†‡§

    Samir Kumar-Singh;Jessie Theuns;Bianca Van Broeck;Daniel Pirici

  • Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3

    C Van Broeckhoven;H Backhovens;H Backhovens;M Cruts;G De Winter;G De Winter

  • Frontotemporal dementia and its subtypes: a genome-wide association study

    Raffaele Ferrari;Raffaele Ferrari;Dena G Hernandez;Dena G Hernandez;Michael A Nalls;Jonathan D Rohrer

  • The role of tau (MAPT) in frontotemporal dementia and related tauopathies.

    R. Rademakers;M. Cruts;C. van Broeckhoven

  • hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

    Kohji Mori;Sven Lammich;Ian R. A. Mackenzie;Ignasi Forné

  • The genetics and neuropathology of frontotemporal lobar degeneration

    Anne Sieben;Tim Van Langenhove;Sebastiaan Engelborghs;Jean-Jacques Martin

  • A Pan‐European Study of the C9orf72 Repeat Associated with FTLD: Geographic Prevalence, Genomic Instability, and Intermediate Repeats

    Julie van der Zee;Ilse Gijselinck;Lubina Dillen;Tim Van Langenhove

Frequent Co-Authors

Christine Van Broeckhoven
Christine Van Broeckhoven University of Antwerp
Sebastiaan Engelborghs
Sebastiaan Engelborghs University of Antwerp
Peter Paul De Deyn
Peter Paul De Deyn University of Antwerp
Kristel Sleegers
Kristel Sleegers University of Antwerp
Patrick Cras
Patrick Cras University of Antwerp
Rosa Rademakers
Rosa Rademakers University of Antwerp
Samir Kumar-Singh
Samir Kumar-Singh University of Antwerp
Albert Hofman
Albert Hofman Harvard University
Jurgen Del-Favero
Jurgen Del-Favero University of Antwerp

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