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Biology and Biochemistry

D-Index
49
Citations
12877
World Ranking
17876
National Ranking
7316

Overview

Mark Hannink is affiliated with the University of Missouri in the United States and specializes in Biochemistry, Genetics, and Molecular Biology, with significant contributions to Molecular Biology, Cell Biology, Artificial Intelligence, Cancer Research, and Pulmonary and Respiratory Medicine.

Their recent research spans interdisciplinary applications, including biomedical text mining, molecular mechanisms of disease, and computational methods within biological contexts. Key research topics include:

  • Biomedical Text Mining and Ontologies
  • Endoplasmic Reticulum Stress and Disease
  • Topic Modeling
  • Protein Degradation and Inhibitors
  • Ubiquitin and Proteasome Pathways
  • Genomics and Phylogenetic Studies
  • Histone Deacetylase Inhibitors Research

Several papers authored by Mark Hannink emphasize experimental and computational approaches to cancer biology and biomedical data analysis. Selected recent publications are:

  • Drug Repositioning and Subgroup Discovery for Precision Medicine Implementation in Triple Negative Breast Cancer, 2021, Cancers
  • Heme oxygenase promotes B-Raf-dependent melanosphere formation, 2020, Pigment Cell & Melanoma Research
  • Identifying Genes and Their Interactions from Pathway Figures and Text in Biomedical Articles, 2021, 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
  • Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1, 2023, Molecular Cancer Therapeutics
  • Applications of cutting-edge artificial intelligence technologies in biomedical literature and document mining, 2023, Medical Review

Mark Hannink frequently collaborates with researchers including Adrian Schwarzer, Marc-Jens Kleppa, Mihail Popescu, Dong Xu, and Matheus Oliveira. These collaborations reflect multidisciplinary efforts across molecular biology and computational biomedical fields.

Their work has appeared in diverse scientific venues such as:

  • Cancers
  • 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
  • Molecular Cancer Therapeutics
  • Pigment Cell & Melanoma Research
  • Medical Review

Best Publications

  • Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

    Donna D. Zhang;Mark Hannink

  • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

    Donna D. Zhang;Shih Ching Lo;Janet V. Cross;Dennis J. Templeton

  • Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.

    Sara B. Cullinan;Donna Zhang;Mark Hannink;Edward Arvisais

  • Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation

    Jodi R. Alt;John L. Cleveland;Mark Hannink;J. Alan Diehl

  • The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

    Dean W. Ballard;William H. Walker;Stefan Doerre;Prakash Sista

  • Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

    Donna D. Zhang;Shih Ching Lo;Zheng Sun;Geetha M. Habib

  • Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases

    Grace Y. Sun;Agnes Simonyi;Kevin L. Fritsche;Dennis Y. Chuang

  • Crystal Structure of the Kelch Domain of Human Keap1

    Xuchu Li;Donna Zhang;Mark Hannink;Lesa J. Beamer

  • Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Theembryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in medaka (Orizias latipes)

    Susannah M. Cantrell;Linda H. Lutz;Donald E. Tillitt;Mark Hannink

  • Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences.

    Shrikesh Sachdev;Alexander Hoffmann;Mark Hannink

  • Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1.

    Grace Y. Sun;Zihong Chen;Kimberly J. Jasmer;Dennis Y. Chuang

  • Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

    Aimee L. Eggler;Evan Small;Mark Hannink;Andrew D. Mesecar

  • Modulation of phototropic responsiveness in Arabidopsis through ubiquitination of phototropin 1 by the CUL3-Ring E3 ubiquitin ligase CRL3(NPH3).

    Diana Roberts;Ullas V. Pedmale;Johanna Morrow;Shrikesh Sachdev

  • Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival

    Xiao-ming Liu;Kelly J. Peyton;Kelly J. Peyton;Diana Ensenat;Hong Wang

  • Structure and function of platelet-derived growth factor (PDGF) and related proteins.

    Mark Hannink;Daniel J. Donoghue

  • Dihydro-CDDO-Trifluoroethyl Amide (dh404), a Novel Nrf2 Activator, Suppresses Oxidative Stress in Cardiomyocytes

    Tomonaga Ichikawa;Jinqing Li;Colin J. Meyer;Joseph S. Janicki

  • Effects of interventions on oxidative stress and inflammation of cardiovascular diseases.

    Sewon Lee;Yoonjung Park;Mozow Yusof Zuidema;Mark Hannink

  • Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli.

    Zengli Yu;Ping Li;Mei Zhang;Mark Hannink

  • Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules.

    B A Lee;D W Maher;M Hannink;D J Donoghue

  • Distinct signaling pathways for induction of type II NOS by IFNγ and LPS in BV-2 microglial cells

    Siming Shen;Sue Yu;Joshua Binek;Malgorzata Chalimoniuk;Malgorzata Chalimoniuk

Frequent Co-Authors

Dennis B. Lubahn
Dennis B. Lubahn University of Missouri
Grace Y. Sun
Grace Y. Sun University of Missouri
Donald E. Tillitt
Donald E. Tillitt United States Geological Survey
Anthony H. Futerman
Anthony H. Futerman Weizmann Institute of Science
Donna D. Zhang
Donna D. Zhang University of Arizona
Pascal Genschik
Pascal Genschik University of Strasbourg
William Durante
William Durante University of Missouri
Timothy A. McKinsey
Timothy A. McKinsey University of Colorado Anschutz Medical Campus
Gilbert G. Privé
Gilbert G. Privé University of Toronto
Dong Xu
Dong Xu University of Missouri

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