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Medicine

D-Index
79
Citations
17357
World Ranking
17756
National Ranking
1612

Overview

Alan R. Crossman is affiliated with the University of Manchester in the United Kingdom, with a research focus primarily in Medicine and Neuroscience. Their work spans the subfields of Neurology and Cellular and Molecular Neuroscience, with particular attention given to neurological disorders and treatments, especially those related to Parkinson's Disease. The topics covered in their research include Parkinson's Disease mechanisms and treatments, neuroscience and neuropharmacology research, and genetic neurodegenerative diseases.

The scientist has contributed to multiple publications in respected journals. Notable recent papers include "µ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease" published in 2020 in the Journal of Neuroscience, and "Professor Tipu Aziz (1956-2024)" published in 2025 in Movement Disorders.

Frequent coauthors collaborating with Alan R. Crossman are:

  • Erwan Bézard
  • Qin Li
  • Heather Hulme
  • Elva Fridjonsdottir
  • Anna Nilsson

The primary publication venues where their research appears include:

  • Journal of Neuroscience
  • Movement Disorders

The body of work by Alan R. Crossman mainly addresses neurological disorders and treatments, with a strong emphasis on Parkinson's disease. Their research contributes to the understanding of disease mechanisms and explores therapeutic strategies. The intersection of neuroscience and neuropharmacology forms a substantial basis of their study, advancing insights into how cellular and molecular processes influence neurological conditions.

Best Publications

  • Relationship between the Appearance of Symptoms and the Level of Nigrostriatal Degeneration in a Progressive 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Macaque Model of Parkinson's Disease

    Erwan Bezard;Erwan Bezard;Sandra Dovero;Caroline Prunier;Paula Ravenscroft

  • Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate.

    T. Z. Aziz;D. Peggs;M. A. Sambrook;A. R. Crossman

  • Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

    I.J. Mitchell;C.E. Clarke;S. Boyce;R.G. Robertson

  • Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

    Matthieu F. Bastide;Wassilios G. Meissner;Barbara Picconi;Stefania Fasano

  • Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study.

    K.A. Sieradzan;S.H. Fox;M. Hill;J.P.R. Dick

  • Primate models of dyskinesia: The experimental approach to the study of basal ganglia-related involuntary movement disorders

    A.R. Crossman

  • Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease.

    Vincenzo Di Marzo;Michael P. Hill;Tiziana Bisogno;Alan R. Crossman

  • Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate.

    Jonathan M. Brotchie;Ian J. Mitchell;Michael A. Sambrook;Alan R. Crossman

  • Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease.

    Brian Henry;Alan R. Crossman;Jonathan M. Brotchie

  • Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

    Penelope J. Hallett;A.W. Dunah;Paula Ravenscroft;Shaobo Zhou

  • Chorea and myoclonus in the monkey induced by gamma-aminobutyric acid antagonism in the lentiform complex: the site of drug action and a hypothesis for the neural mechanisms of chorea

    A R Crossman;I J Mitchell;M A Sambrook;Alan Jackson

  • On the role of enkephalin cotransmission in the GABAergic striatal efferents to the globus pallidus

    Yannick P. Maneuf;Ian J. Mitchell;Alan R. Crossman;Jonathan M. Brotchie

  • Effect of repeated L-DOPA, bromocriptine, or lisuride administration on preproenkephalin-A and preproenkephalin-B mRNA levels in the striatum of the 6-hydroxydopamine-lesioned rat.

    Brian Henry;Alan R. Crossman;Jonathan M. Brotchie

  • A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease.

    Mario van der Stelt;Susan H. Fox;Michael Hill;Alan R. Crossman

  • The projections from the parafascicular thalamic nucleus to the subthalamic nucleus and the striatum arise from separate neuronal populations: A comparison with the corticostriatal and corticosubthalamic efferents in a retrograde fluorescent double-labelling study

    J. Féger;M. Bevan;A.R. Crossman

  • Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the macaque monkey include the ventral tegmental area and the locus coeruleus

    I.J. Mitchell;A.J. Cross;M.A. Sambrook;A.R. Crossman

  • Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

    Juha-Matti Savola;Michael Hill;Mia Engstrom;Hannele Merivuori

  • Direct Targeted Quantitative Molecular Imaging of Neurotransmitters in Brain Tissue Sections

    Mohammadreza Shariatgorji;Anna Nilsson;Richard J.A. Goodwin;Patrik Källback

  • μ- and δ-Opioid Receptor Antagonists Reduce Levodopa-Induced Dyskinesia in the MPTP-Lesioned Primate Model of Parkinson's Disease

    Brian Henry;Susan H. Fox;Alan R. Crossman;Jonathan M. Brotchie

  • The efferent projections of the nucleus accumbens in the rat

    D.J. Williams;A.R. Crossman;P. Slater

Frequent Co-Authors

Jonathan M. Brotchie
Jonathan M. Brotchie University Health Network
M.A. Sambrook
M.A. Sambrook University of Manchester
Erwan Bezard
Erwan Bezard University of Bordeaux
Christian E. Gross
Christian E. Gross University of Bordeaux
Paul D. Griffiths
Paul D. Griffiths University College London
Qin Li
Qin Li Peking Union Medical College Hospital
Mark D. Bevan
Mark D. Bevan Northwestern University
Pierre-Olivier Fernagut
Pierre-Olivier Fernagut University of Poitiers
M. Angela Cenci
M. Angela Cenci Lund University
Henrik Klitgaard
Henrik Klitgaard UCB Pharma (Belgium)

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