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Neuroscience

D-Index
31
Citations
5396
World Ranking
9568
National Ranking
710

Overview

M.A. Sambrook is affiliated with the University of Manchester in the United Kingdom. Their research primarily revolves around the fields of Biochemistry, Genetics and Molecular Biology, with a focus also on Neuroscience.

Their research contributions span several specific areas within these fields, including:

  • Receptor Mechanisms and Signaling
  • Pharmacological Receptor Mechanisms and Effects
  • Neuropeptides and Animal Physiology

Sambrook has published work primarily in molecular biology and cellular and molecular neuroscience subfields. These areas underline a scientific focus on understanding molecular and cellular processes driving physiological responses and signaling mechanisms.

Among their recent publications is the paper titled "NaloxoDARTs: Development and Characterization of Tethered Antagonists for Blockade of Mu Opioid Receptors in Discrete Neuronal Populations", published in 2025 in the SSRN Electronic Journal.

Frequent collaborators in their research include:

  • Julie Sanchez
  • Alessandro Bonifazi
  • Sam Groom
  • Gisela Camacho Hernandez
  • Eloise J. Kuijer

Sambrook's contributions appear primarily in the SSRN Electronic Journal, indicating a focus on disseminating research through this platform.

Best Publications

  • Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate.

    T. Z. Aziz;D. Peggs;M. A. Sambrook;A. R. Crossman

  • Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

    I.J. Mitchell;C.E. Clarke;S. Boyce;R.G. Robertson

  • Experimental hemichorea/ hemiballismus in the monkey: Studies on the intracerebral site of action in a drug-induced dyskinesia

    A. R. Crossman;M. A. Sambrook;A. Jackson

  • Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate.

    Jonathan M. Brotchie;Ian J. Mitchell;Michael A. Sambrook;Alan R. Crossman

  • Chorea and myoclonus in the monkey induced by gamma-aminobutyric acid antagonism in the lentiform complex: the site of drug action and a hypothesis for the neural mechanisms of chorea

    A R Crossman;I J Mitchell;M A Sambrook;Alan Jackson

  • Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the macaque monkey include the ventral tegmental area and the locus coeruleus

    I.J. Mitchell;A.J. Cross;M.A. Sambrook;A.R. Crossman

  • A 2-deoxyglucose study of the effects of dopamine agonists on the parkinsonian primate brain. Implications for the neural mechanisms that mediate dopamine agonist-induced dyskinesia.

    I. J. Mitchell;S. Boyce;M. A. Sambrook;A. R. Crossman

  • Injection of excitatory amino acid antagonists into the medial pallidal segment of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated primate reverses motor symptoms of parkinsonism

    W.C. Graham;R.G. Robertson;M.A. Sambrook;A.R. Crossman

  • Regional brain uptake of 2-deoxyglucose in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkey.

    A.R. Crossman;I.J. Mitchell;M.A. Sambrook

  • Subthalamic nucleotomy alleviates parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed primate

    Tipu Z. Aziz;David Peggs;Elisabeth Agarwal;Michael A. Sambrook

  • Levodopa-induced dyskinesia and response fluctuations in primates rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)☆

    C.E. Clarke;M.A. Sambrook;I.J. Mitchell;A.R. Crossman

  • Neural mechanisms of dystonia: Evidence from a 2-deoxyglucose uptake study in a primate model of dopamine agonist-induced dystonia

    I. J. Mitchell;R. Luquin;S. Boyce;C. E. Clarke

  • The role of the subthalamic nucleus in experimental chorea. Evidence from 2-deoxyglucose metabolic mapping and horseradish peroxidase tracing studies.

    I J Mitchell;Alan Jackson;M A Sambrook;A R Crossman

  • MPTP-induced parkinsonism in the monkey: neurochemical pathology, complications of treatment and pathophysiological mechanisms.

    A.R. Crossman;C.E. Clarke;S. Boyce;R.G. Robertson

  • Differential effect of chronic dopaminergic treatment on dopamine D1 and D2 receptors in the monkey brain in MPTP-induced parkinsonism.

    W.C. Graham;M.A. Sambrook;A.R. Crossman

  • Autoradiographic studies in animal models of hemi-parkinsonism reveal dopamine D2 but not D1 receptor supersensitivity. II. Unilateral intra-carotid infusion of MPTP in the monkey (Macaca fascicularis).

    W.C. Graham;C.E. Clarke;S. Boyce;M.A. Sambrook

  • SUBCORTICAL CHANGES IN THE REGIONAL UPTAKE OF [3H]-2-DEOXYGLUCOSE IN THE BRAIN OF THE MONKEY DURING EXPERIMENTAL CHOREIFORM DYSKINESIA ELICITED BY INJECTION OF A GAMMA-AMINOBUTYRIC ACID ANTAGONIST INTO THE SUBTHALAMIC NUCLEUS

    I. J. Mitchell;M. A. Sambrook;A. R. Crossman

  • Dyskinesia in the primate following injection of an excitatory amino acid antagonist into the medial segment of the globus pallidus

    R.G. Robertson;S.M. Farmery;M.A. Sambrook;A.R. Crossman

  • Effect of the NMDA antagonist MK-801 on MPTP-induced parkinsonism in the monkey.

    A.R. Crossman;D. Peggs;S. Boyce;M.R. Luquin

  • The role of striatopallidal neurones utilizing gamma-aminobutyric acid in the pathophysiology of MPTP-induced parkinsonism in the primate: evidence from [3H]flunitrazepam autoradiography

    R.G. Robertson;C.A. Clarke;S. Boyce;M.A. Sambrook

  • Experimental torticollis in the monkey produced by unilateral 6-hydroxydopamine brain lesions

    A.R. Crossman;M.A. Sambrook

Frequent Co-Authors

Tipu Z. Aziz
Tipu Z. Aziz University of Oxford
Robert H. Perry
Robert H. Perry Newcastle University

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