World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
112
Citations
58518
World Ranking
336
National Ranking
23

Medicine

D-Index
116
Citations
66586
World Ranking
4283
National Ranking
421

Overview

J. Carl Barrett is affiliated with AstraZeneca in the United Kingdom and has contributed extensively to the fields of medicine, biochemistry, genetics, and molecular biology. Their research spans multiple subfields including molecular biology, oncology, cardiology and cardiovascular medicine, radiology, nuclear medicine and imaging, as well as pulmonary and respiratory medicine. Barrett's work encompasses a range of topics predominantly focused on cancer research and molecular diagnostics.

The scientist's research areas include:

  • HER2/EGFR in Cancer Research
  • Advanced Biosensing Techniques and Applications
  • Monoclonal and Polyclonal Antibodies Research
  • Cancer Genomics and Diagnostics
  • BRCA gene mutations in cancer
  • DNA Repair Mechanisms
  • Cell Adhesion Molecules Research

Barrett's publication record features papers in several notable scientific venues. Frequent publication outlets include:

  • Cancer Research
  • PLOS Digital Health
  • Scientific Reports
  • Molecular Oncology
  • Journal of Visualized Experiments

Among recent publications are:

  • Abstract PD6-01: Novel approach to HER2 quantification: Digital pathology coupled with AI-based image and data analysis delivers objective and quantitative HER2 expression analysis for enrichment of responders to trastuzumab deruxtecan (T-DXd; DS-8201), specifically in HER2-low patients, 2021, Cancer Research
  • HER2 quantitative continuous scoring for accurate patient selection in HER2 negative trastuzumab deruxtecan treated breast cancer, 2024, Scientific Reports
  • Serial monitoring of genomic alterations in circulating tumor cells of ER-positive/HER2-negative advanced breast cancer: feasibility of precision oncology biomarker detection, 2021, Molecular Oncology
  • Insights from a single centre implementation of a digitally-enabled atrial fibrillation virtual ward, 2024, PLOS Digital Health
  • Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis, 2021, Journal of Visualized Experiments

Barrett frequently collaborates with a consistent group of co-authors, indicating interdisciplinary teamwork in their research efforts. These co-authors include Hadassah Sade, Ansh Kapil, Sadia Khan, Susanne Haneder, and Ana Hidalgo-Sastre.

Best Publications

  • A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

    Yoshio Miki;Jeff Swensen;Donna Shattuck-Eidens;P. Andrew Futreal

  • Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability

    Asad Umar;C. Richard Boland;Jonathan P. Terdiman;Sapna Syngal

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.

    Eriko Michishita;Jean Y. Park;Jenna M. Burneskis;J. Carl Barrett

  • Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: A preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial

    Jonathan Ledermann;Philipp Harter;Charlie Gourley;Michael Friedlander

  • Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M

    Kenneth S Thress;Cloud P Paweletz;Enriqueta Felip;Byoung Chul Cho

  • GoMiner: a resource for biological interpretation of genomic and proteomic data

    Barry R Zeeberg;Weimin Feng;Geoffrey Wang;May D Wang

  • SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

    Eriko Michishita;Ronald A. McCord;Elisabeth Berber;Mitomu Kioi

  • Microarrays and toxicology: the advent of toxicogenomics.

    Emile F. Nuwaysir;Michael Bittner;Jeffrey Trent;J. Carl Barrett

  • Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

    Olga A. Sedelnikova;Izumi Horikawa;Drazen B. Zimonjic;Nicholas C. Popescu

  • Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non–Small-Cell Lung Cancer

    Geoffrey R. Oxnard;Kenneth S. Thress;Ryan S. Alden;Rachael Lawrance

  • HIF‐1α induces cell cycle arrest by functionally counteracting Myc

    Minori Koshiji;Yukio Kageyama;Erin A Pete;Izumi Horikawa

  • VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research

    Zhongwu Lai;Aleksandra Markovets;Miika Ahdesmaki;Brad Chapman

  • Calorie Restriction, Aging, and Cancer Prevention: Mechanisms of Action and Applicability to Humans*

    Stephen D. Hursting;Jackie A. Lavigne;David Berrigan;Susan N. Perkins

  • Clinical proteomics: translating benchside promise into bedside reality

    Emanuel F. Petricoin;Kathryn C. Zoon;Elise C. Kohn;J. Carl Barrett

  • Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial

    Amit M Oza;David Cibula;Ana Oaknin Benzaquen;Christopher Poole

  • Gene expression analysis reveals chemical-specific profiles.

    Hisham K. Hamadeh;Pierre R. Bushel;Supriya Jayadev;Karla Martin

  • Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancer.

    Kristin K. Zorn;Tomas Bonome;Lisa Gangi;Gadisetti V.R. Chandramouli

  • EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291

    Kenneth S. Thress;Roz Brant;T. Hedley Carr;Simon Dearden

  • Osimertinib As First-Line Treatment of EGFR Mutation-Positive Advanced Non-Small-Cell Lung Cancer.

    Suresh S. Ramalingam;James C.-H. Yang;Chee Khoon Lee;Takayasu Kurata

Frequent Co-Authors

Mitsuo Oshimura
Mitsuo Oshimura Tottori University
Stephen D. Hursting
Stephen D. Hursting University of North Carolina at Chapel Hill
Cynthia A. Afshari
Cynthia A. Afshari Janssen (United States)
Andrew Berchuck
Andrew Berchuck Duke University
Vladimir Larionov
Vladimir Larionov National Institutes of Health
John T. Isaacs
John T. Isaacs Johns Hopkins University
John A. McLachlan
John A. McLachlan Tulane University
P. Andrew Futreal
P. Andrew Futreal The University of Texas MD Anderson Cancer Center
Jonathan A. Ledermann
Jonathan A. Ledermann University College London
Paul Nettesheim
Paul Nettesheim National Institutes of Health

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