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Biology and Biochemistry

D-Index
47
Citations
12317
World Ranking
18583
National Ranking
851

Overview

Paule Bénit is a researcher affiliated with Grenoble Alpes University in France, with a strong focus on biochemistry, genetics, and molecular biology. Their work primarily intersects molecular biology, physiology, and cancer research, with additional contributions to cell biology and endocrinology, diabetes, and metabolism.

The main areas of Bénit's scientific investigation include:

  • Mitochondrial Function and Pathology
  • Adipose Tissue and Metabolism
  • Metabolomics and Mass Spectrometry Studies
  • Cancer, Hypoxia, and Metabolism
  • ATP Synthase and ATPases Research
  • Aldose Reductase and Taurine
  • Hormonal Regulation and Hypertension

Their publication record reflects extensive research output, with papers appearing in journals such as Scientific Reports, eLife, and bioRxiv (Cold Spring Harbor Laboratory), alongside contributions to Cancer Research and Nature Metabolism.

Selected recent papers authored or co-authored by Paule Bénit include:

  • "Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate," 2021, Cancer Research
  • "A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism," 2024, Nature Metabolism
  • "Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly," 2020, Cell Reports
  • "Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad," 2022, Biomedicines
  • "Pitfalls in Monitoring Mitochondrial Temperature Using Charged Thermosensitive Fluorophores," 2020, Chemosensors

The researcher collaborates frequently with a number of colleagues, including:

  • Pierre Rustin
  • Malgorzata Rak
  • Howard T. Jacobs
  • Mügen Terzioglu
  • Riyad El-Khoury

Bénit's contributions are predominantly situated in the domain of biochemistry with a strong molecular and metabolic biology emphasis, addressing complex mechanisms related to mitochondrial function and cellular metabolism. Their work contributes to a deeper understanding of metabolic regulation, cancer-related metabolic pathways, and mitochondrial dynamics.

Best Publications

  • The complete DNA sequence of yeast chromosome III.

    S. G. Oliver;Q. J. M. van der Aart;M. L. Agostoni-Carbone;M. Aigle

  • SDHA is a tumor suppressor gene causing paraganglioma

    Nelly Burnichon;Jean-Jacques Brière;Rossella Libé;Laure Vescovo

  • SDH mutations establish a hypermethylator phenotype in paraganglioma.

    Eric Letouzé;Cosimo Martinelli;Cosimo Martinelli;Céline Loriot;Céline Loriot;Nelly Burnichon;Nelly Burnichon

  • AIF deficiency compromises oxidative phosphorylation

    Nicola Vahsen;Céline Candé;Jean Jacques Brière;Paule Bénit

  • Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.

    Eugenia Morselli;Guillermo Mariño;Guillermo Mariño;Guillermo Mariño;Martin V. Bennetzen;Tobias Eisenberg

  • Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.

    Timothy Wai;Jaime García-Prieto;Michael J. Baker;Carsten Merkwirth

  • Targeted Deletion of AIF Decreases Mitochondrial Oxidative Phosphorylation and Protects from Obesity and Diabetes

    J. Andrew Pospisilik;Claude Knauf;Nicholas Joza;Paule Benit

  • Mitochondria are physiologically maintained at close to 50 °C.

    Dominique Chretien;Paule Benit;Paule Benit;Hyung-Ho Ha;Susanne Keipert

  • Large-Scale Deletion and Point Mutations of the Nuclear NDUFV1 and NDUFS1 Genes in Mitochondrial Complex I Deficiency

    Paule Bénit;Dominique Chretien;Nohman Kadhom;Pascale de Lonlay-Debeney

  • The Warburg effect is genetically determined in inherited pheochromocytomas.

    Judith Favier;Jean-Jacques Brière;Nelly Burnichon;Julie Rivière

  • Muscle-Specific Loss of Apoptosis-Inducing Factor Leads to Mitochondrial Dysfunction, Skeletal Muscle Atrophy, and Dilated Cardiomyopathy

    Nicholas Joza;Nicholas Joza;Gavin Y. Oudit;Doris Brown;Paule Bénit

  • S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase

    Victor Aguilar;Victor Aguilar;Samira Alliouachene;Samira Alliouachene;Athanassia Sotiropoulos;Athanassia Sotiropoulos;Andrew Sobering;Andrew Sobering

  • Coenzyme Q10 and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits

    Vanna Geromel;Niklas Darin;Dominique Chrétien;Paule Bénit

  • Mutant NDUFS3 subunit of mitochondrial complex I causes Leigh syndrome

    P Bénit;A Slama;F Cartault;I Giurgea

  • Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis.

    Emilie Hangen;Olivier Féraud;Olivier Féraud;Sylvie Lachkar;Haiwei Mou

  • Life with or without AIF

    Emilie Hangen;Emilie Hangen;Emilie Hangen;Klas Blomgren;Klas Blomgren;Paule Bénit;Paule Bénit;Guido Kroemer;Guido Kroemer;Guido Kroemer

  • Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy.

    Paule Bénit;Réjane Beugnot;Dominique Chretien;Irina Giurgea

  • The mitochondrial DNA G13513A MELAS mutation in the NADH dehydrogenase 5 gene is a frequent cause of Leigh-like syndrome with isolated complex I deficiency

    M Chol;S Lebon;P Bénit;D Chretien

  • Mitochondrial succinate is instrumental for HIF1α nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions

    Jean Jacques Brière;Judith Favier;Paule Bénit;Vincent El Ghouzzi

  • Mitochondrial Cytochrome c Oxidase Deficiency

    Malgorzata Rak;Paule Bénit;Paule Bénit;Dominique Chrétien;Dominique Chrétien;Juliette Bouchereau;Juliette Bouchereau

Frequent Co-Authors

Guido Kroemer
Guido Kroemer Université Paris Cité
Arnold Munnich
Arnold Munnich Necker-Enfants Malades Hospital
Dominique Chretien
Dominique Chretien Grenoble Alpes University
Anne-Paule Gimenez-Roqueplo
Anne-Paule Gimenez-Roqueplo Université Paris Cité
Alfredo Criollo
Alfredo Criollo University of Chile
Maria Chiara Maiuri
Maria Chiara Maiuri Institut Gustave Roussy
Guillermo Mariño
Guillermo Mariño University of Oviedo
Josef M. Penninger
Josef M. Penninger University of British Columbia

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