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Microbiology

D-Index
69
Citations
13075
World Ranking
2108
National Ranking
882

Overview

Lauren O. Bakaletz is affiliated with The Ohio State University in the United States. Their research primarily focuses on bacterial infections, biofilms, and respiratory diseases, contributing extensively to both medical and microbiological fields.

The main fields of study associated with this scientist include Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these broader categories, their subfields cover Microbiology, Epidemiology, Molecular Biology, Pulmonary and Respiratory Medicine, and Immunology.

Their research topics emphasize bacterial infections and vaccines, pneumonia and respiratory infections, bacterial biofilms and quorum sensing, along with neutrophil, myeloperoxidase and oxidative mechanisms, respiratory and cough-related research, antibiotic resistance in bacteria, and antimicrobial peptides and activities.

Lauren O. Bakaletz has contributed to several scientific publications with recurring appearances in the following venues:

  • Frontiers in Microbiology
  • EBioMedicine
  • Biofilm
  • The Laryngoscope
  • npj Biofilms and Microbiomes

Recent notable papers include:

  • "Z-form extracellular DNA is a structural component of the bacterial biofilm matrix," 2021, Cell
  • "Bacterial Biofilms Utilize an Underlying Extracellular DNA Matrix Structure That Can Be Targeted for Biofilm Resolution," 2022, Microorganisms
  • "Targeting a bacterial DNABII protein with a chimeric peptide immunogen or humanised monoclonal antibody to prevent or treat recalcitrant biofilm-mediated infections," 2020, EBioMedicine
  • "Nontypeable Haemophilus influenzae newly released (NRel) from biofilms by antibody-mediated dispersal versus antibody-mediated disruption are phenotypically distinct," 2020, Biofilm
  • "The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation," 2021, Journal of Clinical Investigation

Frequent collaborators in these research efforts include Steven D. Goodman, Laura A. Novotny, Aishwarya Devaraj, and Joseph A. Jurcisek.

Best Publications

  • Biofilms Formed by Nontypeable Haemophilus influenzae In Vivo Contain both Double-Stranded DNA and Type IV Pilin Protein

    Joseph A. Jurcisek;Lauren O. Bakaletz

  • Nontypeable Haemophilus influenzae as a pathogen in children.

    Timothy F. Murphy;Howard Faden;Lauren O. Bakaletz;Jennelle M. Kyd

  • Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins

    S D Goodman;K P Obergfell;J A Jurcisek;L A Novotny

  • Differential Type I Interferon Induction by Respiratory Syncytial Virus and Influenza A Virus In Vivo

    Nancy A. Jewell;Negin Vaghefi;Sara E. Mertz;Parvis Akter

  • Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20.

    Alistair Harrison;David W. Dyer;Allison Gillaspy;William C. Ray

  • Food commensal microbes as a potentially important avenue in transmitting antibiotic resistance genes

    Hua H. Wang;Michele Manuzon;Mark Lehman;Kai Wan

  • What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention.

    John S. Gunn;John S. Gunn;Lauren O. Bakaletz;Daniel J. Wozniak;Daniel J. Wozniak

  • Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis media.

    K Suzuki;L O Bakaletz

  • Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A.

    T. Sirakova;P. E. Kolattukudy;D. Murwin;J. Billy

  • Microbial interactions in the respiratory tract.

    Timothy F. Murphy;Lauren O. Bakaletz;Pierre R. Smeesters

  • Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

    Colette Cywes-Bentley;David Skurnik;Tanweer Zaidi;Damien Roux

  • Particulate Matter in the Posterior Semicircular Canal

    D. Bradley Welling;Lorne S. Parnes;Blaize O'Brien;Lauren O. Bakaletz

  • Viral-bacterial co-infections in the respiratory tract.

    Lauren O Bakaletz

  • Viral potentiation of bacterial superinfection of the respiratory tract

    Lauren O. Bakaletz

  • Developing animal models for polymicrobial diseases

    Lauren O. Bakaletz

  • The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract.

    Joseph A. Jurcisek;James E. Bookwalter;Beth D. Baker;Soledad Fernandez

  • Z-form extracellular DNA is a structural component of the bacterial biofilm matrix

    John R. Buzzo;Aishwarya Devaraj;Erin S. Gloag;Joseph A. Jurcisek

  • Phosphorylcholine Decreases Early Inflammation and Promotes the Establishment of Stable Biofilm Communities of Nontypeable Haemophilus influenzae Strain 86-028NP in a Chinchilla Model of Otitis Media

    Wenzhou Hong;Kevin Mason;Joseph Jurcisek;Laura Novotny

  • Frequency of fimbriation of nontypable Haemophilus influenzae and its ability to adhere to chinchilla and human respiratory epithelium.

    L. O. Bakaletz;B. M. Tallan;T. Hoepf;T. F. DeMaria

  • Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection.

    Lauren O. Bakaletz;Bobbie-Jo Kennedy;Laura A. Novotny;Guy Duquesne

  • Role of Sialic Acid and Complex Carbohydrate Biosynthesis in Biofilm Formation by Nontypeable Haemophilus influenzae in the Chinchilla Middle Ear

    Joseph Jurcisek;Laura Greiner;Hiroshi Watanabe;Anthony Zaleski

Frequent Co-Authors

Michael P. Jennings
Michael P. Jennings Griffith University
Pappachan E. Kolattukudy
Pappachan E. Kolattukudy University of Central Florida
Timothy F. Murphy
Timothy F. Murphy University at Buffalo, State University of New York
Allan W. Cripps
Allan W. Cripps Griffith University
Allen F. Ryan
Allen F. Ryan University of California, San Diego
Joan E. Durbin
Joan E. Durbin Rutgers, The State University of New Jersey
Kate L. Seib
Kate L. Seib Griffith University
Stephen I. Pelton
Stephen I. Pelton Boston University
Michael T. Bailey
Michael T. Bailey The Ohio State University
John D. Clements
John D. Clements Tulane University

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