Kumao Toyoshima

Best Publications

• Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.

  Tadashi Yamamoto;Shuntaro Ikawa;Tetsu Akiyama;Tetsu Akiyama;Kentaro Semba

  1613
  Citations

• The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity.

  Tetsu Akiyama;Chie Sudo;Hiroshi Ogawara;Kumao Toyoshima

  1114
  Citations

• A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma

  Kentaro Semba;Nobuyuki Kamata;Kumao Toyoshima;Tadashi Yamamoto

  898
  Citations

• Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene

  Hiroyuki Shibata;Kaoru Toyama;Hisashi Shioya;Masaki Ito

  678
  Citations

• Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

  Akihiko Matsumine;Akiko Ogai;Takao Senda;Nobuaki Okumura

  579
  Citations

• Association of B cell antigen receptor with protein tyrosine kinase Lyn

  Yuji Yamanashi;Terutaka Kakiuchi;Junichiro Mizuguchi;Tadashi Yamamoto

  570
  Citations

• Maturation of Human Dendritic Cells by Cell Wall Skeleton of Mycobacterium bovis Bacillus Calmette-Guérin: Involvement of Toll-Like Receptors

  Shoutaro Tsuji;Misako Matsumoto;Osamu Takeuchi;Shizuo Akira

  541
  Citations

• Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo.

  Jun Yokota;Kumao Toyoshima;Takashi Sugimura;Tadashi Yamamoto

  488
  Citations

• Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells

  Glenn T. Merlino;Young Hua Xu;Shunsuke Ishii;Adrian J.L. Clark

  467
  Citations

• K-ras is essential for the development of the mouse embryo.

  Keiko Koera;Kenji Nakamura;Kazuki Nakao;Jun Miyoshi

  461
  Citations

• Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall

  Shoutaro Tsuji;Junji Uehori;Misako Matsumoto;Yasuhiko Suzuki

  447
  Citations

• The erbB gene of avian erythroblastosis virus is a member of the src gene family

  Tadashi Yamamoto;Tsutomu Nishida;Nobuyuki Miyajima;Sadaaki Kawai

  440
  Citations

• Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level

  Tsutomu Nakamura;Fumihiko Hamada;Fumihiko Hamada;Takao Ishidate;Takao Ishidate;Ken-ichi Anai

  430
  Citations

• Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus

  N Kitamura;A Kitamura;K Toyoshima;Y Hirayama

  364
  Citations

• Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.

  Nobuyuki Miyajima;Ryuya Horiuchi;Yukiko Shibuya;Shin ichi Fukushige

  326
  Citations

• Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other

  Nobuyuki Miyajtma;Yasunori Kandowaki;Shin Ichi Fukushige;Sho Ichi Shimizu

  318
  Citations

• Phosphorylation of the retinoblastoma protein by cdk2

  Tetsu Akiyama;Tohru Ohuchi;Shuji Sumida;Kunihiro Matsumoto

  292
  Citations

• Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling

  Yuji Yamanashi;Yasuhisa Fukui;Budsaba Wongsasant;Yumiko Kinoshita

  286
  Citations

• The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase.

  Takao Ishidate;Akihiko Matsumine;Kumao Toyoshima;Tetsu Akiyama;Tetsu Akiyama

  272
  Citations

• Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.

  Fumihiko Hamada;Fumihiko Hamada;Yoshinori Tomoyasu;Yoshihiro Takatsu;Makoto Nakamura

  248
  Citations