World's Best Scientists 2026 revealed!

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Immunology

D-Index
71
Citations
16040
World Ranking
2346
National Ranking
93

Overview

Weisan Chen is affiliated with La Trobe University in Australia and has contributed extensively to the fields of medicine and immunology and microbiology. Their research spans multiple subfields including immunology, infectious diseases, molecular biology, epidemiology, and surgery.

The scientist's work frequently appears in several publication venues. These include:

  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Cambridge Structural Database
  • Nature Communications
  • Journal for ImmunoTherapy of Cancer

Recent significant papers authored or co-authored by the scientist cover a range of topics related to immune cell response, viral infections, and inflammation:

  • CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses (2021, Immunity)
  • Suboptimal SARS-CoV-2−specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype (2020, Proceedings of the National Academy of Sciences)
  • Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response (2021, Nature Communications)
  • TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis (2020, Nature Immunology)
  • Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (2020, Journal of Medicinal Chemistry)

Chen's frequent co-authors include Yuan Zhuang, Jianxin Chen, Ping Cheng, Quanming Zou, and Yong-sheng Teng, with whom they have collaborated multiple times across research projects.

Their research topics can be grouped under the following:

  • Immune Cell Function and Interaction
  • Vaccines and Immunoinformatics Approaches
  • Helicobacter pylori-related Gastroenterology Studies
  • SARS-CoV-2 and COVID-19 Research
  • Immunotherapy and Immune Responses
  • COVID-19 Clinical Research Studies
  • Influenza Virus Research Studies

Within the broader medical sciences domain, Chen's focus includes the immune system's response to pathogens, particularly in viral infections such as SARS-CoV-2, as well as therapeutic strategies to modulate immunity and inflammation. Their work also addresses molecular and cellular mechanisms related to immunity and infectious diseases, contributing to understanding host-pathogen interactions and immune-mediated processes.

Best Publications

  • A novel influenza A virus mitochondrial protein that induces cell death

    Weisan Chen;Paul A. Calvo;Daniela Malide;James Gibbs

  • Exosomes and their roles in immune regulation and cancer

    David W. Greening;Shashi K. Gopal;Rong Xu;Richard J. Simpson

  • Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans.

    Ian D. Davis;Weisan Chen;Heather Jackson;Phillip Parente;Phillip Parente

  • Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway

    Ting-ting Wang;Yong-liang Zhao;Liu-sheng Peng;Na Chen

  • Dissecting the Multifactorial Causes of Immunodominance in Class I–Restricted T Cell Responses to Viruses

    Weisan Chen;Luis C. Antón;Jack R. Bennink;Jonathan W. Yewdell

  • Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes

    Karin A Sedelies;Thomas J Sayers;Kirsten M Edwards;Weisan Chen

  • Immunoproteasomes Shape Immunodominance Hierarchies of Antiviral Cd8+ T Cells at the Levels of T Cell Repertoire and Presentation of Viral Antigens

    Weisan Chen;Weisan Chen;Christopher C. Norbury;Yunjung Cho;Jonathan W. Yewdell

  • Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.

    Weisan Chen;Sergei Khilko;John Fecondo;David H. Margulies

  • Genome-Wide Identification of Long Noncoding RNAs in CD8+ T Cells

    Ken C. Pang;Marcel E. Dinger;Tim R. Mercer;Lorenzo Malquori

  • Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery

    Max Schnurr;Qiyuan Chen;Qiyuan Chen;Amanda Shin;Amanda Shin;Weisan Chen;Weisan Chen

  • The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells.

    Lisa M Ebert;Bee Shin Tan;Judy Browning;Suzanne Svobodova

  • A virus-specific CD8 + T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

    Nicole L. La Gruta;Katherine Kedzierska;Ken C Pang;Richard Webby

  • CD8+ T Cells That Produce Interleukin-17 Regulate Myeloid-Derived Suppressor Cells and Are Associated With Survival Time of Patients With Gastric Cancer

    Yuan Zhuang;Liu–Sheng Peng;Yong–Liang Zhao;Yun Shi

  • RNAdb—a comprehensive mammalian noncoding RNA database

    Ken C. Pang;Stuart Stephen;Pär G. Engström;Khairina Tajul-Arifin

  • NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8+ T cells

    Andreas Kupz;Greta Guarda;Thomas Gebhardt;Leif E Sander

  • Suboptimal SARS-CoV-2-specific CD8 + T cell response associated with the prominent HLA-A*02:01 phenotype.

    Jennifer R. Habel;Thi H.O. Nguyen;Carolien E. van de Sandt;Carolien E. van de Sandt;Jennifer A. Juno

  • CD8 + T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses.

    Katie E. Lineburg;Emma J. Grant;Emma J. Grant;Srividhya Swaminathan;Srividhya Swaminathan;Demetra S.M. Chatzileontiadou;Demetra S.M. Chatzileontiadou

  • Tumor-Associated Monocytes/Macrophages Impair NK-Cell Function via TGFβ1 in Human Gastric Cancer

    Liu-sheng Peng;Jin-yu Zhang;Yong-sheng Teng;Yong-liang Zhao

  • Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants.

    Weisan Chen;Jonathan W. Yewdell;Rodney L. Levine;Jack R. Bennink

  • The spleen in liver cirrhosis: revisiting an old enemy with novel targets

    Liang Li;Mubing Duan;Weisan Chen;Weisan Chen;An Jiang

  • Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: differential regulation of function by specific classes of physiologic stimuli.

    Michael Jefford;Michael Jefford;Michael Jefford;Max Schnurr;Max Schnurr;Max Schnurr;Tracey Toy;Tracey Toy;Tracey Toy;Kelly-Anne Masterman;Kelly-Anne Masterman;Kelly-Anne Masterman

Frequent Co-Authors

Jonathan Cebon
Jonathan Cebon La Trobe University
Ian D. Davis
Ian D. Davis Monash University
Eugene Maraskovsky
Eugene Maraskovsky CSL (United Kingdom)
Jamie Rossjohn
Jamie Rossjohn Monash University
James McCluskey
James McCluskey University of Melbourne
Jonathan W. Yewdell
Jonathan W. Yewdell National Institute of Allergy and Infectious Diseases
Jack R. Bennink
Jack R. Bennink National Institute of Allergy and Infectious Diseases
Peter C. Doherty
Peter C. Doherty University of Melbourne
Lloyd J. Old
Lloyd J. Old Ludwig Cancer Research
Katherine Kedzierska
Katherine Kedzierska University of Melbourne

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