World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
19144
World Ranking
11732
National Ranking
5047

Research.com Recognitions

  • 1998 - Fellow of American Physical Society (APS) Citation For innovative and unique research in chaos and nonlinear dynamics, and in the evolution of largescale solar plasma eruptions and their impact on the magnetosphere

Overview

James K. Chen is affiliated with Stanford University in the United States. Their research spans multiple fields, primarily focusing on Medicine, as well as Biochemistry, Genetics, and Molecular Biology. Within these fields, their work delves into several specialized subfields including Molecular Biology, Oncology, Mechanical Engineering, Materials Chemistry, and Cancer Research.

Their scholarly output includes contributions to various research topics such as:

  • Cancer Genomics and Diagnostics
  • Hedgehog Signaling Pathway Studies
  • Epigenetics and DNA Methylation
  • Advanced biosensing and bioanalysis techniques
  • Colorectal Cancer Surgical Treatments
  • Colorectal Cancer Screening and Detection
  • Welding Techniques and Residual Stresses

James K. Chen frequently publishes in venues like bioRxiv (Cold Spring Harbor Laboratory), JCI Insight, Nature Chemical Biology, Science and Technology of Welding & Joining, and Cancer Research. These publications reflect a range of interdisciplinary research interests.

Selected recent papers authored or coauthored by this scientist include:

  • Organic wastewater treatment by a single-atom catalyst and electrolytically produced H2O2, 2020, Nature Sustainability
  • A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients, 2021, JCI Insight
  • Lanthanide-Based Optical Probes of Biological Systems, 2020, Cell Chemical Biology
  • Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata, 2021, JCI Insight
  • HIPK4 is essential for murine spermiogenesis, 2020, eLife

Throughout their research career, James K. Chen has collaborated extensively with several frequent coauthors, including Zhiping Feng, Jiapeng Huang, Marisa E. Hom, Alison E. Ondrus, and Alexander Deiters.

James K. Chen was recognized as a Fellow of the American Physical Society (APS) in 1998, for innovative and unique research in chaos and nonlinear dynamics, and in the evolution of largescale solar plasma eruptions and their impact on the magnetosphere.

Best Publications

  • Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

    James K. Chen;Jussi Taipale;Michael K. Cooper;Philip A. Beachy

  • Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

    Jussi Taipale;James K. Chen;Michael K. Cooper;Baolin Wang

  • Structural basis for the binding of proline-rich peptides to SH3 domains

    Hongtao Yu;James K. Chen;Sibo Feng;David C. Dalgarno

  • Small molecule modulation of Smoothened activity.

    James K. Chen;Jussi Taipale;Keith E. Young;Tapan Maiti

  • Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions.

    Sibo Feng;James K. Chen;Hongtao Yu;Julian A. Simon

  • Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

    David M. Berman;Sunil S. Karhadkar;Andrew R. Hallahan;Joel I. Pritchard

  • Organic wastewater treatment by a single-atom catalyst and electrolytically produced H2O2.

    Jinwei Xu;Xueli Zheng;Zhiping Feng;Zhiyi Lu

  • Stromal response to Hedgehog signaling restrains pancreatic cancer progression.

    John J. Lee;Rushika M. Perera;Huaijun Wang;Dai-Chen Wu

  • Purmorphamine activates the Hedgehog pathway by targeting Smoothened

    Surajit Sinha;James K Chen

  • Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

    Ari J. Firestone;Joshua S. Weinger;Maria Maldonado;Kari Barlan

  • Intracranial Dural Arteriovenous Fistulas: Classification, Imaging Findings, and Treatment

    Dheeraj Gandhi;J. Chen;M. Pearl;J. Huang

  • The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

    Alex J. Kuo;Jikui Song;Jikui Song;Peggie Cheung;Satoko Ishibe-Murakami

  • Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

    Joel M. Hyman;Ari J. Firestone;Vivi M. Heine;Yun Zhao

  • Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2

    Wei Chen;Xiu-Rong Ren;Christopher D. Nelson;Larry S. Barak

  • A small molecule that binds Hedgehog and blocks its signaling in human cells

    Benjamin Z Stanton;Lee F Peng;Lee F Peng;Nicole Maloof;Kazuo Nakai

  • A crucial requirement for Hedgehog signaling in small cell lung cancer

    Kwon Sik Park;Luciano G. Martelotto;Martin Peifer;Martin L. Sos

  • Light-controlled gene silencing in zebrafish embryos

    Ilya A Shestopalov;Surajit Sinha;Surajit Sinha;James K Chen

  • An inducible long noncoding RNA amplifies DNA damage signaling.

    Adam M Schmitt;Julia T Garcia;Tiffany Hung;Ryan A Flynn

  • Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage

    Jason Yi;Xufeng Wu;Andrew H. Chung;James K. Chen

  • Small-molecule inhibitors of the AAA1 ATPase motor cytoplasmic dynein

    Ari J. Firestone;Joshua S. Weinger;Maria Maldonado;Kari Barlan

Frequent Co-Authors

Philip A. Beachy
Philip A. Beachy Stanford University
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Tarun M. Kapoor
Tarun M. Kapoor Rockefeller University
Maxence V. Nachury
Maxence V. Nachury University of California, San Francisco
Jussi Taipale
Jussi Taipale University of Cambridge
Vladimir I. Gelfand
Vladimir I. Gelfand Northwestern University
Tomas Cihlar
Tomas Cihlar Gilead Sciences (United States)
Joshua E. Elias
Joshua E. Elias Stanford University
Hongtao Yu
Hongtao Yu The University of Texas Southwestern Medical Center
Choung U. Kim
Choung U. Kim Bristol-Myers Squibb (Germany)

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