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Rune Toftgård

Rune Toftgård

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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
21887
World Ranking
6207
National Ranking
91

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award

Overview

Rune Toftgård is a researcher affiliated with the Karolinska Institute in Sweden. Their work primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with particular focus on subfields such as Molecular Biology, Genetics, Oncology, and Cancer Research.

The scientist's recent publications reflect a concentration on genetic and molecular mechanisms related to cancer and disease. Notable papers include:

  • Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Krüppel-like factor 5 (Klf5), 2021, Transgenic Research
  • The origin of cancer, 2021, Journal of Internal Medicine

Toftgård's research engages with several key topics, including:

  • Kruppel-like factors research
  • Genetic Syndromes and Imprinting
  • Renal and related cancers
  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • Epigenetics and DNA Methylation

Frequent collaborators in their work include Åsa Bergström, Marco Gerling, Noémi Van Hul, Carlos Fernández Moro, and Björn Rozell.

Their findings have been published in venues such as Transgenic Research and the Journal of Internal Medicine, illustrating an interdisciplinary approach bridging molecular biology and clinical perspectives in oncology.

Best Publications

  • Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

    Heidi Hahn;Carol Wicking;Peter G Zaphiropoulos;Mae R Gailani

  • Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

    Viljar Jaks;Nick Barker;Maria Kasper;Johan H. van Es

  • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

    Matthias Lauth;Asa Bergström;Takashi Shimokawa;Rune Toftgård

  • The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.

    M R Gailani;M Ståhle-Bäckdahl;D J Leffell;M Glynn

  • Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

    Hugo J. G. Snippert;Andrea Haegebarth;Maria Kasper;Viljar Jaks

  • Hedgehog beyond medulloblastoma and basal cell carcinoma.

    Stephan Teglund;Rune Toftgård

  • Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1.

    Priit Kogerman;Thomas Grimm;Lembi Kogerman;Darren Krause

  • Genetic Elimination of Suppressor of Fused Reveals an Essential Repressor Function in the Mammalian Hedgehog Signaling Pathway

    Jessica Svärd;Karin Heby-Henricson;Madelen Persson-Lek;Björn Rozell

  • Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1.

    Mats Nilsson;Anne Birgitte Undèn;Darren Krause;Ulrica Malmqwist

  • Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.

    K Gradin;J McGuire;R H Wenger;I Kvietikova

  • 3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

    Paola Longati;Xiaohui Jia;Johannes Eimer;Annika Wagman

  • Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling.

    M van Hogerlinden;B L Rozell;L Ahrlund-Richter;R Toftgård

  • Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus

    Kevin Lee;JaeWook Jeong;Inseok Kwak;Cheng-Tai Yu

  • Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1.

    Rebecca L.H. Bigelow;Nikhil S. Chari;Anne Birgitte Undén;Kevin B. Spurgers

  • Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development

    Ulrica Tostar;Carl Johan Malm;Jeanne M. Meis-Kindblom;Lars Gunnar Kindblom

  • A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities

    Heidi Hahn;Jeffrey Christiansen;Carol Wicking;Peter G. Zaphiropoulos

  • Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy.

    Matthias Lauth;Rune Toftgård

  • Indian hedgehog and β-catenin signaling: Role in the sebaceous lineage of normal and neoplastic mammalian epidermis

    C. Niemann;A. B. Unden;S. Lyle;Ch. C. Zouboulis

  • Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours.

    I Vorechovský;O Tingby;M Hartman;B Strömberg

  • Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site.

    Marie Ågren;Priit Kogerman;Priit Kogerman;Marika I. Kleman;Martina Wessling

Frequent Co-Authors

Jan-Åke Gustafsson
Jan-Åke Gustafsson University of Houston
Dennis R. Roop
Dennis R. Roop University of Colorado Anschutz Medical Campus
Michael Dean
Michael Dean National Institutes of Health
Allen E. Bale
Allen E. Bale Yale University
Carol Wicking
Carol Wicking University of Queensland
Nick Barker
Nick Barker Agency for Science, Technology and Research
Brandon J. Wainwright
Brandon J. Wainwright University of Queensland
Igor Vorechovsky
Igor Vorechovsky University of Southampton
Kurt Andersson
Kurt Andersson Karolinska Institute
Lorenz Poellinger
Lorenz Poellinger Karolinska Institute

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