His primary areas of investigation include Genetics, Patched, Sonic hedgehog, Cell biology and Hedgehog signaling pathway. His research in the fields of Mutation, Gene, Phenotype and Mutant overlaps with other disciplines such as Position-effect variegation. The study incorporates disciplines such as Nevoid basal-cell carcinoma syndrome, Cancer research and Segment polarity gene in addition to Patched.
His Nevoid basal-cell carcinoma syndrome research incorporates elements of Tumor suppressor gene, PTCH2 and PTCH1 Gene. His Cancer research research integrates issues from Basal Cell Nevus Syndrome and Loss of heterozygosity. Carol Wicking combines subjects such as Ciliogenesis, Molecular biology and Hedgehog, Smoothened with his study of Sonic hedgehog.
His primary areas of study are Genetics, Cell biology, Gene, Patched and Sonic hedgehog. His Cell biology research includes elements of Internal medicine, Endocrinology and Anatomy. The Patched study combines topics in areas such as Carcinogenesis, Nevoid basal-cell carcinoma syndrome, Cancer research and Segment polarity gene.
His work carried out in the field of Nevoid basal-cell carcinoma syndrome brings together such families of science as Tumor suppressor gene, PTCH2, Basal Cell Nevus Syndrome and PTCH1 Gene. Carol Wicking interconnects Keratin 1, Regulation of gene expression and Limb development in the investigation of issues within Sonic hedgehog. His Hedgehog signaling pathway study combines topics from a wide range of disciplines, such as Morphogenesis, Embryonic stem cell and Hedgehog.
Carol Wicking mostly deals with Genetics, Cell biology, Cilium, Compound heterozygosity and Intraflagellar transport. His is involved in several facets of Genetics study, as is seen by his studies on Basal body, Zebrafish, Mutation, Phenotype and Gene. Many of his studies on Cell biology apply to Anatomy as well.
His research in Cilium intersects with topics in Ciliopathies and Ciliopathy. His Intraflagellar transport study also includes
Genetics, Cilium, Intraflagellar transport, Transport protein and Basal body are his primary areas of study. His studies link Evolutionary biology with Genetics. His work deals with themes such as Ciliopathy and Hedgehog signaling pathway, which intersect with Cilium.
His Hedgehog signaling pathway research incorporates themes from Internal medicine, Hedgehog, INPP5E and Scaffold protein. His Intraflagellar transport study incorporates themes from Sonic hedgehog, General surgery and Ciliogenesis. Particularly relevant to PTCH1 is his body of work in Cell biology.
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Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Heidi Hahn;Carol Wicking;Peter G Zaphiropoulos;Mae R Gailani.
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched
Torsten Pietsch;Andreas Waha;Anke Koch;Jürgen Kraus.
Cancer Research (1997)
Nevoid basal cell carcinoma syndrome: Review of 118 affected individuals
Susan Shanley;John Ratcliffe;Athel Hockey;Eric Haan.
American Journal of Medical Genetics (1994)
Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the patched protein, and no genotype-phenotype correlations are evident
Carol Wicking;Susan Shanley;Ian Macleod Smyth;Susan Gillies.
American Journal of Human Genetics (1997)
Correction: Corrigendum: TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport
Miriam Schmidts;Yuqing Hou;Claudio R. Cortes;Dorus A. Mans.
Nature Communications (2016)
A Genome-Wide Association Study Identifies Five Loci Influencing Facial Morphology in Europeans
Fan Liu;Fedde van der Lijn;Claudia Schurmann;Gu Zhu.
PLOS Genetics (2012)
A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
Heidi Hahn;Jeffrey Christiansen;Carol Wicking;Peter G. Zaphiropoulos.
Journal of Biological Chemistry (1996)
Isolation and Characterization of Human Patched 2 (PTCH2), a Putative Tumour Suppressor Gene in Basal Cell Carcinoma and Medulloblastoma on Chromosome 1p32
Ian Macleod Smyth;Monica A Narang;Tim Evans;Cornelia Heimann.
Human Molecular Genetics (1999)
The hedgehog signalling pathway in tumorigenesis and development.
Carol Wicking;Ian Smyth;Allen Bale.
Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development
Jeffrey H. Christiansen;Carina L. Dennis;Carol A. Wicking;Susan J. Monkley.
Mechanisms of Development (1995)
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