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Neuroscience

D-Index
48
Citations
13916
World Ranking
6092
National Ranking
2660

Overview

Michael Costigan is affiliated with Boston Children's Hospital in the United States. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Subfields of focus include Physiology, Cellular and Molecular Neuroscience, Molecular Biology, Neurology, and Genetics.

Costigan's work engages with a range of topics such as Pain Mechanisms and Treatments, Nerve injury and regeneration, Ion channel regulation and function, Pharmacological Receptor Mechanisms and Effects, Neuropeptides and Animal Physiology, Genetic Neurodegenerative Diseases, and Neurogenetic and Muscular Disorders Research.

Recent publications by Costigan include the following:

  • Mendelian etiologies identified with whole exome sequencing in cerebral palsy, 2022, Annals of Clinical and Translational Neurology
  • Cytotoxic Immunity in Peripheral Nerve Injury and Pain, 2020, Frontiers in Neuroscience
  • Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer, 2022, Science Translational Medicine
  • Human induced pluripotent stem cell-derived GABAergic interneuron transplants attenuate neuropathic pain, 2020, Pain
  • Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons, 2021, Cell Reports

Frequent co-authors in Costigan's research include Clifford J. Woolf, Josef Penninger, Rafael González-Cano, Luda Diatchenko, and William Maixner.

Their work has been published most often in UNC Libraries, followed by Frontiers in Neuroscience, Frontiers in Pharmacology, bioRxiv (Cold Spring Harbor Laboratory), and Annals of Clinical and Translational Neurology.

Best Publications

  • Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

    Michael Costigan;Joachim Scholz;Clifford J. Woolf

  • Transcriptional and posttranslational plasticity and the generation of inflammatory pain

    Clifford J. Woolf;Michael Costigan

  • GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

    Irmgard Tegeder;Michael Costigan;Robert S Griffin;Andrea Abele

  • Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury.

    Michael Costigan;Katia Befort;Laurie Karchewski;Robert S Griffin

  • Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity

    R. J. Mannion;M. Costigan;I. Decosterd;F. Amaya

  • T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity.

    Michael Costigan;Andrew Moss;Andrew Moss;Alban Latremoliere;Caroline Johnston;Caroline Johnston

  • Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.

    Robert E. Sorge;Tuan Trang;Ruslan Dorfman;Shad B. Smith

  • A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program.

    Vijayendran Chandran;Giovanni Coppola;Giovanni Coppola;Homaira Nawabi;Takao Omura

  • The Voltage-Gated Sodium Channel Nav1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity

    Fumimasa Amaya;Haibin Wang;Michael Costigan;Andrew J. Allchorne

  • A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene

    G. Gregory Neely;G. Gregory Neely;Andreas Hess;Michael Costigan;Alex C. Keene

  • Pain: molecular mechanisms.

    Michael Costigan;Clifford J. Woolf

  • Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons.

    Simon Tate;Susanna Benn;Caroline Anne Hick;Derek J Trezise

  • TRPA1 contributes to cold hypersensitivity.

    Donato del Camino;Sarah Murphy;Melissa Heiry;Lee B. Barrett

  • Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2

    Fumimasa Amaya;Isabelle Decosterd;Tarek A. Samad;Christopher Plumpton

  • Complement Induction in Spinal Cord Microglia Results in Anaphylatoxin C5a-Mediated Pain Hypersensitivity

    Robert S. Griffin;Michael Costigan;Gary J. Brenner;Chi Him Eddie Ma

  • Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice

    Chi Him Eddie Ma;Takao Omura;Enrique J. Cobos;Alban Latrémolière

  • Multiple chronic pain states are associated with a common amino acid–changing allele in KCNS1

    Michael Costigan;Inna Belfer;Robert S. Griffin;Feng Dai

  • Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2.

    Natalie S. Delany;Michael Hurle;Paul Facer;Tanja Alnadaf

  • The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

    Shane J. F. Cronin;Shane J. F. Cronin;Shane J. F. Cronin;Corey Seehus;Corey Seehus;Adelheid Weidinger;Sebastien Talbot;Sebastien Talbot;Sebastien Talbot

  • TrpA1 regulates thermal nociception in Drosophila.

    G. Gregory Neely;G. Gregory Neely;Alex C. Keene;Peter Duchek;Elaine C. Chang

  • Multiple chronic pain states are associated with a common amino acid changing allele in KCNS1 (vol 133, pg 2519, 2010)

    Michael Costigan;Inna Belfer;Robert S. Griffin;Feng Dai

Frequent Co-Authors

Clifford J. Woolf
Clifford J. Woolf Boston Children's Hospital
Daniel H. Geschwind
Daniel H. Geschwind University of California, Los Angeles
Seog Bae Oh
Seog Bae Oh Seoul National University
Maria Fitzgerald
Maria Fitzgerald University College London
Simon Beggs
Simon Beggs University of Toronto
Larry I. Benowitz
Larry I. Benowitz Harvard Medical School
Zhigang He
Zhigang He Boston Children's Hospital
Ze'ev Seltzer
Ze'ev Seltzer University of Toronto
David Goldman
David Goldman National Institutes of Health
Rohini Kuner
Rohini Kuner Heidelberg University

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