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Biology and Biochemistry

D-Index
61
Citations
9926
World Ranking
11609
National Ranking
890

Overview

John M. Kelly is affiliated with the London School of Hygiene & Tropical Medicine in the United Kingdom. Their research primarily focuses on Medicine, with significant contributions to Epidemiology, Public Health, Environmental and Occupational Health, Organic Chemistry, Molecular Biology, and Parasitology.

The scientist's work covers a range of topics, notably Trypanosoma species research and implications, Research on Leishmaniasis Studies, Synthesis and Biological Evaluation, Parasites and Host Interactions, Biochemical and Molecular Research, Synthesis and biological activity, and Bioactive Compounds and Antitumor Agents.

Recent notable publications include:

  • In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution, 2020, mBio
  • Challenges in Chagas Disease Drug Development, 2020, Molecules
  • Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate, 2020, Open Biology
  • Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection, 2020, PLoS neglected tropical diseases
  • Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections, 2023, Science

Frequent co-authors in their research collaborations include:

  • Martin C. Taylor
  • Amanda Fortes Francisco
  • Shiromani Jayawardhana
  • Michael D. Lewis
  • Francisco Olmo

The scientist has published extensively in several venues, reflecting the multidisciplinary nature of their research. These publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS neglected tropical diseases
  • European Journal of Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • OPAL (Open@LaTrobe) (La Trobe University)

Best Publications

  • A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.

    Shane R. Wilkinson;Martin C. Taylor;David Horn;John M. Kelly

  • Trypanocidal drugs: mechanisms, resistance and new targets

    Shane R. Wilkinson;John M. Kelly

  • A shuttle vector which facilitates the expression of transfected genes in Trypanosoma cruzi and Leishmania.

    John M. kelly;Helena M. ward;Michael A. Miles;Giles Kendall

  • Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue‐specific parasite dynamics and heart disease in the absence of locally persistent infection

    Michael D. Lewis;Amanda Fortes Francisco;Martin C. Taylor;Hollie Burrell-Saward

  • Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.

    Shane R. Wilkinson;Nigel J. Temperton;Angeles Mondragon;John M. Kelly

  • Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum

    Shane R. Wilkinson;Samson O. Obado;Isabel L. Mauricio;John M. Kelly

  • Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite.

    Lucía Piacenza;Gonzalo Peluffo;María Noel Alvarez;John M. Kelly

  • The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.

    Shane R. Wilkinson;David J. Meyer;Martin C. Taylor;Elizabeth V. Bromley

  • Structure, function and evolution of microbial adenylyl and guanylyl cyclases.

    David A. Baker;John M. Kelly

  • Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase does not conform to the 'hotspot' topogenic signal model.

    G. Kendall;A. F. Wilderspin;F. Ashall;M. A. Miles

  • Identification and characterisation of a Leishmania donovani antigen belonging to the 70-kDa heat-shock protein family.

    Juan MacFARLANE;Mark L. Blaxter;Richard P. Bishop;Michael A. Miles

  • Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population

    Ana Maria Mejia;Belinda S. Hall;Martin C. Taylor;Andrés Gómez-Palacio

  • Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging

    Amanda Fortes Francisco;Michael D. Lewis;Shiromani Jayawardhana;Martin C. Taylor

  • Comparative photochemical analysis of highly purified 124 kilodalton oat and rye phytochromes in vitro

    J. Clark Lagarias;John M. Kelly;Karen L. Cyr;William O. Smith

  • A putative Leishmania panamensis/Leishmania braziliensis hybrid is a causative agent of human cutaneous leishmaniasis in Nicaragua.

    A. A. Belli;M. A. Miles;J. M. Kelly

  • Trypanocidal Activity of Nitroaromatic Prodrugs: Current Treatments and Future Perspectives

    Shane R. Wilkinson;Christopher Bot;John M. Kelly;Belinda S. Hall

  • TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum.

    Shane R. Wilkinson;Martin C. Taylor;Said Touitha;Isabel L. Mauricio

  • Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression

    Lucía Piacenza;Florencia Irigoín;María Noel Alvarez;Gonzalo Peluffo

  • RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome.

    Shane R. Wilkinson;David Horn;S.Radhika Prathalingam;John M. Kelly

  • Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells.

    J. M. Kelly;A. C. G. Porter;Y. Chernajovsky;C. S. Gilbert

Frequent Co-Authors

Michael A. Miles
Michael A. Miles London School of Hygiene & Tropical Medicine
David Horn
David Horn University of Dundee
Lieve Naesens
Lieve Naesens Rega Institute for Medical Research
Mark Blaxter
Mark Blaxter Wellcome Sanger Institute
Alan H. Fairlamb
Alan H. Fairlamb University of Dundee
Pascal Mäser
Pascal Mäser Swiss Tropical and Public Health Institute
Nigel J. Temperton
Nigel J. Temperton University of Kent
Marcel Kaiser
Marcel Kaiser Swiss Tropical and Public Health Institute
Pauline Schaap
Pauline Schaap University of Dundee

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