David W. Meek

Overview

Best Publications

• Regulation of the specific DNA binding function of p53

  T.R. Hupp;D.W. Meek;C.A. Midgley;D.P. Lane

  1289
  Citations

• Tumour suppression by p53: a role for the DNA damage response?

  David W. Meek

  758
  Citations

• Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

  Nicolas Dumaz;David W. Meek

  615
  Citations

• Posttranslational Modification of p53: Cooperative Integrators of Function

  David W. Meek;Carl W. Anderson

  536
  Citations

• Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation.

  Sari Kurki;Karita Peltonen;Leena Latonen;Taija M Kiviharju

  516
  Citations

• The p53 response to DNA damage.

  David W Meek

  481
  Citations

• The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

  D. W. Meek;S. Simon;U. Kikkawa;W. Eckhart

  373
  Citations

• Mechanisms of switching on p53: a role for covalent modification?

  David W Meek

  357
  Citations

• p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1

  Diane M. Milne;Linda E. Campbell;David G. Campbell;David W. Meek

  353
  Citations

• Regulation of the p53 response and its relationship to cancer.

  David W. Meek

  336
  Citations

• p53 Represses Cyclin D1 Transcription through Down Regulation of Bcl-3 and Inducing Increased Association of the p52 NF-κB Subunit with Histone Deacetylase 1

  Sonia Rocha;Anthea M. Martin;David W. Meek;Neil D. Perkins

  322
  Citations

• Posttranslational modification of MDM2

  David W Meek;Uwe Knippschild

  315
  Citations

• Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

  Jayne Loughery;Miranda Cox;Linda M. Smith;David W. Meek

  302
  Citations

• Multisite phosphorylation and the integration of stress signals at p53.

  David W Meek

  264
  Citations

• Activation of the cryptic DNA binding function of mutant forms of p53

  Ted R. Hupp;David W. Meek;Carol A. Midgley;David P. Lane

  263
  Citations

• Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases

  D M Milne;D G Campbell;F B Caudwell;D W Meek

  243
  Citations

• p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

  U Knippschild;D M Milne;L E Campbell;A J DeMaggio

  242
  Citations

• Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme.

  Milne Dm;Palmer Rh;Campbell Dg;Meek Dw

  218
  Citations

• Post-translational modification of p53.

  D W Meek

  217
  Citations

• Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.

  Nicolas Dumaz;Diane M Milne;David W Meek

  207
  Citations