2026 Kiichi Hirota: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	58	12941	11906	896	840	185	18750

Overview

Kiichi Hirota is affiliated with Kansai Medical University in Japan. Their research spans multiple areas within medicine and biochemistry, with a significant focus on molecular biology and related subfields.

The main fields of study for Hirota include:

Medicine
Biochemistry, Genetics and Molecular Biology

Within these fields, their subfields of study involve:

Molecular Biology
Cancer Research
Pulmonary and Respiratory Medicine
Oncology
Epidemiology

Their work addresses a variety of topics, notably:

Cancer, Hypoxia, and Metabolism
Adipose Tissue and Metabolism
Respiratory Support and Mechanisms
Gut microbiota and health
High Altitude and Hypoxia
COVID-19 Clinical Research Studies
COVID-19 and healthcare impacts

Hirota has published extensively, with some recent papers including:

"Full-length 16S rRNA gene amplicon analysis of human gut microbiota using MinION™ nanopore sequencing confers species-level resolution," 2021, BMC Microbiology
"HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review," 2021, Biomedicines
"Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and Its Implication for Medicine," 2020, Biomedicines
"Characterizing the gut microbiota in females with infertility and preliminary results of a water-soluble dietary fiber intervention study," 2020, Journal of Clinical Biochemistry and Nutrition

Some papers are authored alongside frequent collaborators such as Yoshiyuki Matsuo, Yosuke Fujii, Hidemasa Bono, Hidetaka Okada, and Shinnosuke Komiya.

Publication venues where Hirota has published frequently include:

bioRxiv (Cold Spring Harbor Laboratory)
Biomedicines
Scientific Reports
JA Clinical Reports
Medicina

Best Publications

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Patrick C. Mahon;Kiichi Hirota;Gregg L. Semenza

1785
Citations
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells *

Ryo Fukuda;Kiichi Hirota;Fan Fan;Young Do Jung

1166
Citations
Correction: Corrigendum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels

Hiroshi Harada;Masahiro Inoue;Satoshi Itasaka;Kiichi Hirota

1055
Citations
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

Kiichi Hirota;Minoru Matsui;Satoshi Iwata;Akira Nishiyama

1029
Citations
Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression

Akira Nishiyama;Minoru Matsui;Satoshi Iwata;Kiichi Hirota

866
Citations
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1

Brian D. Kelly;Sean F. Hackett;Kiichi Hirota;Yuji Oshima

836
Citations
Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB.

Kiichi Hirota;Miyahiko Murata;Yoshifumi Sachi;Hajime Nakamura

779
Citations
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

Masatsugu Ema;Kiichi Hirota;Junsei Mimura;Hisaku Abe

741
Citations
Regulation of angiogenesis by hypoxia-inducible factor 1

Kiichi Hirota;Gregg L. Semenza

664
Citations
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Sonny O. Ang;Hua Chen;Kiichi Hirota;Victor R. Gordeuk

621
Citations
Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

Masaya Ueno;Hiroshi Masutani;Roberto Jun Arai;Akira Yamauchi

539
Citations
Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling

Kenji Kasuno;Kenji Kasuno;Satoshi Takabuchi;Kazuhiko Fukuda;Shinae Kizaka-Kondoh

299
Citations
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.

Kiichi Hirota;Gregg L. Semenza

285
Citations
Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer

Toru Hiraga;Shinae Kizaka-Kondoh;Kiichi Hirota;Masahiro Hiraoka

273
Citations
Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system.

Yuichi Makino;Kensaku Okamoto;Noritada Yoshikawa;Masaru Aoshima

264
Citations
Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.

T Sasada;S Iwata;N Sato;Y Kitaoka

248
Citations
Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.

Wei Sj;Botero A;Hirota K;Bradbury Cm

245
Citations
Nucleoredoxin, Glutaredoxin, and Thioredoxin Differentially Regulate NF-κB, AP-1, and CREB Activation in HEK293 Cells

Kiichi Hirota;Minoru Matsui;Miyahiko Murata;Yuichiro Takashima

242
Citations
Direct Association with Thioredoxin Allows Redox Regulation of Glucocorticoid Receptor Function

Yuichi Makino;Noritada Yoshikawa;Kensaku Okamoto;Kiichi Hirota

240
Citations
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1

Kiichi Hirota;Kiichi Hirota;Gregg L. Semenza

223
Citations