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Kiichi Hirota

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
18750
World Ranking
12941
National Ranking
896

Kiichi Hirota publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Kiichi Hirota sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 185 publications — 43rd percentile

43% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Kiichi Hirota D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Kiichi Hirota sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 58 D-Index — 34th percentile

34% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Kiichi Hirota is affiliated with Kansai Medical University in Japan. Their research spans multiple areas within medicine and biochemistry, with a significant focus on molecular biology and related subfields.

The main fields of study for Hirota include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, their subfields of study involve:

  • Molecular Biology
  • Cancer Research
  • Pulmonary and Respiratory Medicine
  • Oncology
  • Epidemiology

Their work addresses a variety of topics, notably:

  • Cancer, Hypoxia, and Metabolism
  • Adipose Tissue and Metabolism
  • Respiratory Support and Mechanisms
  • Gut microbiota and health
  • High Altitude and Hypoxia
  • COVID-19 Clinical Research Studies
  • COVID-19 and healthcare impacts

Hirota has published extensively, with some recent papers including:

  • "Full-length 16S rRNA gene amplicon analysis of human gut microbiota using MinION™ nanopore sequencing confers species-level resolution," 2021, BMC Microbiology
  • "HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review," 2021, Biomedicines
  • "Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and Its Implication for Medicine," 2020, Biomedicines
  • "Characterizing the gut microbiota in females with infertility and preliminary results of a water-soluble dietary fiber intervention study," 2020, Journal of Clinical Biochemistry and Nutrition

Some papers are authored alongside frequent collaborators such as Yoshiyuki Matsuo, Yosuke Fujii, Hidemasa Bono, Hidetaka Okada, and Shinnosuke Komiya.

Publication venues where Hirota has published frequently include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biomedicines
  • Scientific Reports
  • JA Clinical Reports
  • Medicina

Best Publications

  • FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

    Patrick C. Mahon;Kiichi Hirota;Gregg L. Semenza

  • Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells *

    Ryo Fukuda;Kiichi Hirota;Fan Fan;Young Do Jung

  • Correction: Corrigendum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels

    Hiroshi Harada;Masahiro Inoue;Satoshi Itasaka;Kiichi Hirota

  • AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

    Kiichi Hirota;Minoru Matsui;Satoshi Iwata;Akira Nishiyama

  • Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression

    Akira Nishiyama;Minoru Matsui;Satoshi Iwata;Kiichi Hirota

  • Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1

    Brian D. Kelly;Sean F. Hackett;Kiichi Hirota;Yuji Oshima

  • Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB.

    Kiichi Hirota;Miyahiko Murata;Yoshifumi Sachi;Hajime Nakamura

  • Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

    Masatsugu Ema;Kiichi Hirota;Junsei Mimura;Hisaku Abe

  • Regulation of angiogenesis by hypoxia-inducible factor 1

    Kiichi Hirota;Gregg L. Semenza

  • Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

    Sonny O. Ang;Hua Chen;Kiichi Hirota;Victor R. Gordeuk

  • Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

    Masaya Ueno;Hiroshi Masutani;Roberto Jun Arai;Akira Yamauchi

  • Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling

    Kenji Kasuno;Kenji Kasuno;Satoshi Takabuchi;Kazuhiko Fukuda;Shinae Kizaka-Kondoh

  • Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.

    Kiichi Hirota;Gregg L. Semenza

  • Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer

    Toru Hiraga;Shinae Kizaka-Kondoh;Kiichi Hirota;Masahiro Hiraoka

  • Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system.

    Yuichi Makino;Kensaku Okamoto;Noritada Yoshikawa;Masaru Aoshima

  • Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.

    T Sasada;S Iwata;N Sato;Y Kitaoka

  • Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.

    Wei Sj;Botero A;Hirota K;Bradbury Cm

  • Nucleoredoxin, Glutaredoxin, and Thioredoxin Differentially Regulate NF-κB, AP-1, and CREB Activation in HEK293 Cells

    Kiichi Hirota;Minoru Matsui;Miyahiko Murata;Yuichiro Takashima

  • Direct Association with Thioredoxin Allows Redox Regulation of Glucocorticoid Receptor Function

    Yuichi Makino;Noritada Yoshikawa;Kensaku Okamoto;Kiichi Hirota

  • Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1

    Kiichi Hirota;Kiichi Hirota;Gregg L. Semenza

Frequent Co-Authors

Junji Yodoi
Junji Yodoi Kyoto University
Gregg L. Semenza
Gregg L. Semenza Johns Hopkins University School of Medicine
Hiroshi Masutani
Hiroshi Masutani Tenri Health Care University
Masahiro Hiraoka
Masahiro Hiraoka Kyoto University
Hajime Nakamura
Hajime Nakamura Kyoto University
Akira Nishiyama
Akira Nishiyama Kagawa University
Tomohisa Takagi
Tomohisa Takagi Kyoto Prefectural University of Medicine
Hirotoshi Tanaka
Hirotoshi Tanaka Keio University
Jun-Ichi Hayashi
Jun-Ichi Hayashi University of Tsukuba
Kazuhiro Nakamura
Kazuhiro Nakamura Nagoya University

External Links

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Best Scientists Citing Kiichi Hirota

Junji Yodoi

Junji Yodoi

Kyoto University

Publications: 154

Gregg L. Semenza

Gregg L. Semenza

Johns Hopkins University School of Medicine

Publications: 130

Hajime Nakamura

Hajime Nakamura

Kyoto University

Publications: 101

Hiroshi Masutani

Hiroshi Masutani

Tenri Health Care University

Publications: 80

Arne Holmgren

Arne Holmgren

Karolinska Institute

Publications: 62

Peter J. Ratcliffe

Peter J. Ratcliffe

The Francis Crick Institute

Publications: 51

Randall S. Johnson

Randall S. Johnson

University of Cambridge

Publications: 43

Christopher J. Schofield

Christopher J. Schofield

University of Oxford

Publications: 40

William G. Kaelin

William G. Kaelin

Harvard University

Publications: 37

Dean P. Jones

Dean P. Jones

Emory University

Publications: 36

M. Celeste Simon

M. Celeste Simon

University of Pennsylvania

Publications: 34

Thomas Kietzmann

Thomas Kietzmann

University of Oulu

Publications: 33

Shinya Toyokuni

Shinya Toyokuni

Nagoya University

Publications: 29

Masahiro Hiraoka

Masahiro Hiraoka

Kyoto University

Publications: 29

Amato J. Giaccia

Amato J. Giaccia

Stanford University

Publications: 28

Josef T. Prchal

Josef T. Prchal

University of Utah

Publications: 28

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