Hiroshi Shibuya mainly focuses on Cell biology, Wnt signaling pathway, MAP kinase kinase kinase, Biochemistry and Kinase activity. His Cell biology research is multidisciplinary, incorporating elements of Transcriptional regulation and Transactivation. His work deals with themes such as Cancer research, Signalling and Cell fate determination, which intersect with Wnt signaling pathway.
His Kinase activity research integrates issues from c-Raf, Cyclin-dependent kinase 9 and ASK1. His LRP6 research includes elements of Beta-catenin, Ca2+/calmodulin-dependent protein kinase, Biochemical cascade and LRP5. His research in Signal transduction intersects with topics in Tumor necrosis factor alpha, Molecular biology and NFKB1.
His primary scientific interests are in Cell biology, Molecular biology, Kinase, Xenopus and Wnt signaling pathway. His work in the fields of Signal transduction, MAP kinase kinase kinase and Adipogenesis overlaps with other areas such as Ubiquitin ligase. The concepts of his Molecular biology study are interwoven with issues in Transforming growth factor beta, Signal transducing adaptor protein and p38 mitogen-activated protein kinases.
His Kinase research includes themes of SMAD and Phosphorylation. His work investigates the relationship between Wnt signaling pathway and topics such as Cancer research that intersect with problems in RUNX2. In his study, Akt/PKB signaling pathway and MAP2K7 is inextricably linked to ASK1, which falls within the broad field of Kinase activity.
The scientist’s investigation covers issues in Cell biology, Wnt signaling pathway, Signal transduction, Xenopus and Beta-catenin. In general Cell biology study, his work on Adipogenesis, Function and Leucine-rich repeat often relates to the realm of Cascade and Peroxisome proliferator-activated receptor, thereby connecting several areas of interest. His work on LRP6, LRP5 and Catenin as part of general Wnt signaling pathway research is frequently linked to Ubiquitin ligase and Nuclear localization sequence, thereby connecting diverse disciplines of science.
His work carried out in the field of Signal transduction brings together such families of science as Protein kinase A and Effector. His studies in Effector integrate themes in fields like Molecular biology, GSK-3 and Kinase activity. His Beta-catenin study integrates concerns from other disciplines, such as Cancer research, MACF1 and AXIN1.
Wnt signaling pathway, Nuclear localization sequence, Cell biology, Dishevelled and Signal transduction are his primary areas of study. His study on LRP6, LRP5 and Catenin is often connected to Importin and Nuclear transport as part of broader study in Wnt signaling pathway. Hiroshi Shibuya integrates Nuclear localization sequence and Beta-catenin in his research.
Dishevelled is connected with Xenopus and IQGAP1 in his study.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction
Kyoko Yamaguchi;Kyoko Shirakabe;Hiroshi Shibuya;Kenji Irie.
The receptor tyrosine kinase Ror2 is involved in non‐canonical Wnt5a/JNK signalling pathway
Isao Oishi;Hiroaki Suzuki;Nobuyuki Onishi;Ritsuko Takada.
Genes to Cells (2003)
TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction
Hiroshi Shibuya;Kyoko Yamaguchi;Kyoko Shirakabe;Akane Tonegawa.
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
Tohru Ishitani;Jun Ninomiya-Tsuji;Shln Ichl Nagai;Michiru Nishita.
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
Giichi Takaesu;Satoshi Kishida;Atsushi Hiyama;Kyoko Yamaguchi.
Molecular Cell (2000)
The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/β-Catenin Signaling
Tohru Ishitani;Satoshi Kishida;Junko Hyodo-Miura;Junko Hyodo-Miura;Naoto Ueno.
Molecular and Cellular Biology (2003)
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3.
Tetsuo Moriguchi;Noriyo Kuroyanagi;Kyoko Yamaguchi;Yukiko Gotoh.
Journal of Biological Chemistry (1996)
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression.
Hiroshi Hanafusa;Jun Ninomiya-Tsuji;Norihisa Masuyama;Michiru Nishita.
Journal of Biological Chemistry (1999)
Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.
Michiru Nishita;Minako K. Hashimoto;Souichi Ogata;Micheline N. Laurent;Micheline N. Laurent.
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.
Ichiro Takada;Masatomo Mihara;Masatomo Mihara;Miyuki Suzawa;Fumiaki Ohtake.
Nature Cell Biology (2007)
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