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Molecular Biology

D-Index
76
Citations
18986
World Ranking
1156
National Ranking
598

Overview

Xinbin Chen is affiliated with the University of California, Davis in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with 77 publications in these fields. They have significant contributions in medicine, supported by 44 publications, and specialize in molecular biology, cancer research, and oncology as key subfields of study.

The scientist's work covers various main topics related to cancer biology and molecular mechanisms, including:

  • Cancer-related Molecular Pathways
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Epigenetics and DNA Methylation
  • Cancer-related molecular mechanisms research
  • Cancer, Hypoxia, and Metabolism
  • Cancer, Lipids, and Metabolism

Xinbin Chen frequently publishes in prominent scientific journals. The most common publication venues include:

  • Cancer Research
  • Cancers
  • Molecular Cancer Research
  • eLife
  • Frontiers in Cell and Developmental Biology

Among their recent papers are:

  • "FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression" (2020, The Journal of Pathology)
  • "The p53 Family: A Role in Lipid and Iron Metabolism" (2021, Frontiers in Cell and Developmental Biology)
  • "Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression" (2020, Molecular Cancer Research)
  • "Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1-SREBP pathway" (2022, Oncogene)
  • "Olaparib-Induced Senescence Is Bypassed through G2-M Checkpoint Override in Olaparib-Resistant Prostate Cancer" (2022, Molecular Cancer Therapeutics)

Xinbin Chen collaborates with a number of frequent co-authors, which indicates active interdisciplinary and cooperative research efforts. These include:

  • Jin Zhang
  • Mingyi Chen
  • Shakur Mohibi
  • Yanhong Zhang
  • Xiangmudong Kong

Their body of work spans various aspects of cancer molecular biology, including cancer-related pathways, RNA biology, epigenetics, and metabolism, reflecting a broad and integrative approach to understanding tumor biology and related molecular processes.

Best Publications

  • p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

    Xinbin Chen;Linda J. Ko;Lata Jayaraman;Carol Prives

  • Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRB is a critical determinant in blocking DNA replication and in preventing endoreduplication

    Alexander B. Niculescu;Xinbin Chen;Monique Smeets;Ludger Hengst

  • Examination of the expanding pathways for the regulation of p21 expression and activity.

    Yong Sam Jung;Yingjuan Qian;Xinbin Chen

  • The potential tumor suppressor p73 differentially regulates cellular p53 target genes.

    Jianhui Zhu;Jieyuan Jiang;Wenjing Zhou;Xinbin Chen

  • p63α and ΔNp63α can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes

    Michael Dohn;Shungzhen Zhang;Xinbin Chen

  • The common and distinct target genes of the p53 family transcription factors

    K. Harms;S. Nozell;Xinbin Chen

  • The p53 protein is an unusually shaped tetramer that binds directly to DNA.

    Paula N. Friedman;Xinbin Chen;Jill Bargonetti;Carol Prives

  • A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

    Jill Bargonetti;James J. Manfredi;Xinbin Chen;Daniel R. Marshak

  • Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes

    Amy Willis;Eun Joo Jung;Therese Wakefield;Xinbin Chen

  • p53 modulation of the DNA damage response

    E. Scott Helton;Xinbin Chen

  • Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53

    Piyajit Watcharasit;Gautam N. Bijur;Ling Song;Jianhui Zhu

  • Direct, activating interaction between glycogen synthase kinase-3β and p53 after DNA damage

    Piyajit Watcharasit;Gautam N. Bijur;Jaroslaw W. Zmijewski;Ling Song

  • MDM2 Is a Negative Regulator of p21WAF1/CIP1, Independent of p53

    Zhuo Zhang;Hui Wang;Mao Li;Sudhir Agrawal

  • p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.

    Linda J. Ko;Sheau Yann Shieh;Xinbin Chen;Lata Jayaraman

  • The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis.

    Gang Liu;Xinbin Chen

  • The Lysine-specific Demethylase 1 Is Required for Cell Proliferation in Both p53-dependent and -independent Manners *

    Ariane Scoumanne;Xinbin Chen;Xinbin Chen

  • p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis.

    Xinbin Chen;Jill Bargonetti;Carol Prives

  • Identification of a Novel p53 Functional Domain That Is Necessary for Mediating Apoptosis

    Jianhui Zhu;Wenjing Zhou;Jieyuan Jiang;Xinbin Chen

  • Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53.

    Jian Wang;Jiang Shou;Xinbin Chen

  • Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis.

    Michael Dohn;Jieyuan Jiang;Xinbin Chen

Frequent Co-Authors

Gang Liu
Gang Liu University of Alabama at Birmingham
Carol Prives
Carol Prives Columbia University
Hsing Jien Kung
Hsing Jien Kung Taipei Medical University
Hui Wang
Hui Wang Chinese Academy of Sciences
Razqallah Hakem
Razqallah Hakem University of Toronto
Richard S. Jope
Richard S. Jope University of Miami
Buyong Ma
Buyong Ma Shanghai Jiao Tong University
Steven I. Reed
Steven I. Reed Scripps Research Institute
Ron Prywes
Ron Prywes Columbia University

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