His main research concerns Cancer research, Molecular biology, Cell biology, DNA damage and Tumor suppressor gene. His Cancer research research incorporates themes from Apoptosis, Downregulation and upregulation, Mutant, Regulation of gene expression and Prostate cancer. The concepts of his Molecular biology study are interwoven with issues in Gene, Gene knockdown, Mdm2, Transcriptional regulation and Kinase.
His biological study spans a wide range of topics, including Retinoblastoma protein, Proliferating cell nuclear antigen, DNA replication and DNA endoreduplication. His work deals with themes such as Cell cycle checkpoint, Plasma protein binding, Glycogen synthase and GSK-3, which intersect with DNA damage. His Tumor suppressor gene study combines topics from a wide range of disciplines, such as Cell cycle, Signal transduction and Bcl-2-associated X protein.
The scientist’s investigation covers issues in Cell biology, Molecular biology, Cancer research, Gene knockdown and Messenger RNA. His Cell biology research incorporates elements of Cell cycle checkpoint, Cell growth, Apoptosis and Nuclear protein, Transcription factor. His studies deal with areas such as DNA damage and Regulation of gene expression, Mutant, Gene, Ectopic expression as well as Molecular biology.
His study focuses on the intersection of DNA damage and fields such as DNA repair with connections in the field of Senescence. His research investigates the link between Cancer research and topics such as Carcinogenesis that cross with problems in In vivo. Within one scientific family, he focuses on topics pertaining to Mdm2 under Gene knockdown, and may sometimes address concerns connected to Ubiquitin ligase, Oncogene and Chromatin remodeling.
His primary areas of study are Cell biology, Messenger RNA, Cancer research, Carcinogenesis and Regulation of gene expression. His Cell biology study integrates concerns from other disciplines, such as Apoptosis, Transcription factor, Gene and Cell culture. His Messenger RNA research integrates issues from Gene knockdown and Ectopic expression.
His Ectopic expression study combines topics in areas such as Molecular biology and Cell aging. His study in Cancer research is interdisciplinary in nature, drawing from both Chromatin, Cancer, Three prime untranslated region and Programmed cell death. His study looks at the relationship between Regulation of gene expression and topics such as Cell growth, which overlap with DNA damage, Cancer cell and Psychological repression.
Xinbin Chen spends much of his time researching Cancer research, Carcinogenesis, Cell biology, Regulation of gene expression and Molecular biology. The Cancer research study combines topics in areas such as Cancer, Cell growth, Mutant, Chromatin and Three prime untranslated region. His Cell growth research includes elements of Cancer cell, DNA polymerase eta, DNA damage and DNA polymerase.
His work carried out in the field of Carcinogenesis brings together such families of science as RNA, RNA-binding protein, RNA splicing, Computational biology and microRNA. He has included themes like Apoptosis, Messenger RNA, EIF4E and Metabolism in his Cell biology study. His research in Regulation of gene expression intersects with topics in Heart failure, Translation initiation complex, Programmed cell death and Protein biosynthesis.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.
Xinbin Chen;Linda J. Ko;Lata Jayaraman;Carol Prives.
Genes & Development (1996)
Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication
Alexander B. Niculescu;Xinbin Chen;Monique Smeets;Ludger Hengst.
Molecular and Cellular Biology (1998)
The potential tumor suppressor p73 differentially regulates cellular p53 target genes.
Jianhui Zhu;Jieyuan Jiang;Wenjing Zhou;Xinbin Chen.
Cancer Research (1998)
Examination of the expanding pathways for the regulation of p21 expression and activity.
Yong Sam Jung;Yingjuan Qian;Xinbin Chen.
Cellular Signalling (2010)
p63alpha and DeltaNp63alpha Can Induce Cell Cycle Arrest and Apoptosis and Differentially Regulate p53 Target Genes
Michael Dohn;Shungzhen Zhang;Xinbin Chen.
The common and distinct target genes of the p53 family transcription factors
K. Harms;S. Nozell;Xinbin Chen.
Cellular and Molecular Life Sciences (2004)
The p53 protein is an unusually shaped tetramer that binds directly to DNA.
Paula N. Friedman;Xinbin Chen;Jill Bargonetti;Carol Prives.
Proceedings of the National Academy of Sciences of the United States of America (1993)
A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.
Jill Bargonetti;James J. Manfredi;Xinbin Chen;Daniel R. Marshak.
Genes & Development (1993)
Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53
Piyajit Watcharasit;Gautam N. Bijur;Ling Song;Jianhui Zhu.
Journal of Biological Chemistry (2003)
Direct, activating interaction between glycogen synthase kinase-3β and p53 after DNA damage
Piyajit Watcharasit;Gautam N. Bijur;Jaroslaw W. Zmijewski;Ling Song.
Proceedings of the National Academy of Sciences of the United States of America (2002)
Profile was last updated on December 6th, 2021.
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