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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
20585
World Ranking
3576
National Ranking
55

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award

Overview

Klas G. Wiman is a researcher affiliated with the Karolinska Institute in Sweden. Their work primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine. The main areas of study include molecular biology, oncology, and cancer research, with additional interests in biotechnology and public health.

Their research centers on several key topics related to cancer biology. These include cancer-related molecular pathways, epigenetics and DNA methylation, cancer research and treatments, cancer under conditions of hypoxia and metabolism, cancer genomics and diagnostics, acute lymphoblastic leukemia research, and PI3K/AKT/mTOR signaling pathways in cancer.

Frequent publication venues for their work include Cell Death and Disease, Zenodo (CERN European Organization for Nuclear Research), bioRxiv (Cold Spring Harbor Laboratory), Cell Death Discovery, and Nature Reviews Clinical Oncology.

Some recent papers authored or co-authored by Klas G. Wiman are:

  • Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells, 2020, Cell Death Discovery
  • Pharmacological reactivation of p53 in the era of precision anticancer medicine, 2023, Nature Reviews Clinical Oncology
  • Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene, 2020, Cell Death and Differentiation
  • A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death, 2020, EMBO Molecular Medicine
  • Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine, 2022, Cell Death and Disease

Klas G. Wiman has collaborated frequently with several researchers, including Vladimir J.N. Bykov, Angelos Heldin, Mireia Palomar-Siles, Sophia Ceder, and Charlotte Strandgren. These collaborations have produced multiple publications, reflecting ongoing research partnerships.

Best Publications

  • Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

    Vladimir J.N. Bykov;Natalia Issaeva;Alexandre Shilov;Monica Hultcrantz

  • Targeting mutant p53 for efficient cancer therapy

    Vladimir J N Bykov;Sofi E Eriksson;Julie Bianchi;Klas G Wiman

  • PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

    Jeremy M.R. Lambert;Jeremy M.R. Lambert;Petr Gorzov;Dimitry B. Veprintsev;Maja Söderqvist

  • Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain.

    Galina Selivanova;Violetta Iotsova;Violetta Iotsova;Ismail Okan;Michael Fritsche

  • WHAT IS THE RESTRICTION POINT

    Anders Zetterberg;Olle Larsson;Klas G Wiman

  • Shaping genetic alterations in human cancer: the p53 mutation paradigm.

    Thierry Soussi;Klas G. Wiman

  • Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

    Sören Lehmann;Vladimir J.N. Bykov;Dina Ali;Ove Andrén

  • EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins

    Laszlo Szekely;Galina Selivanova;Kristinn P. Magnusson;George Klein

  • Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.

    Dan Larhammar;Lena Schenning;Kenth Gustafsson;Klas Wiman

  • Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens.

    Sune Kvist;Klas Wiman;Lena Claesson;Per A. Peterson

  • Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

    Dawei Xu;Qian Wang;Astrid Gruber;Magnus Björkholm

  • The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer.

    Marianne Farnebo;Vladimir J.N. Bykov;Klas G. Wiman

  • p14ARF deletion and methylation in genetic pathways to glioblastomas.

    Mitsutoshi Nakamura;Takao Watanabe;Ulf Klangby;Charlotte Asker

  • Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

    Salah Mahmoudi;Sofia Henriksson;Martin Corcoran;Cristina Méndez-Vidal

  • Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus

    Adrian C. Hayday;Stephen D. Gillies;Haruo Saito;Charles Wood

  • TP53: an oncogene in disguise

    T Soussi;K G Wiman

  • Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation

    David Shi Hao Liu;Cuong Phu Duong;Sue Haupt;Karen G Montgomery

  • Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs

    Vladimir J. N. Bykov;Natalia Issaeva;Nicole Zache;Alexandre Shilov

  • PRIMA-1 MET synergizes with cisplatin to induce tumor cell apoptosis

    Vladimir J N Bykov;Nicole Zache;Helene Stridh;Jacob Westman

  • Mutations and selection in the generation of class II histocompatibility antigen polymorphism.

    K Gustafsson;K Wiman;E Emmoth;D Larhammar

Frequent Co-Authors

Galina Selivanova
Galina Selivanova Karolinska Institute
George Klein
George Klein Karolinska Institute
Per A. Peterson
Per A. Peterson Scripps Research Institute
Lars Rask
Lars Rask Uppsala University
Pierre Hainaut
Pierre Hainaut Grenoble Alpes University
Jan Bergman
Jan Bergman Karolinska Institute
Carleen Cullinane
Carleen Cullinane Peter MacCallum Cancer Centre
Dan Grandér
Dan Grandér Karolinska Institute
Ygal Haupt
Ygal Haupt Peter MacCallum Cancer Centre
Dan Larhammar
Dan Larhammar Uppsala University

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