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Biology and Biochemistry

D-Index
65
Citations
12007
World Ranking
9367
National Ranking
129

Overview

Dan Grandér was affiliated with the Karolinska Institute in Sweden. Their research primarily contributed to the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a total of nine publications in molecular biology and four in oncology. Their subfield expertise also touched on Immunology and Inorganic Chemistry.

Their work covered several key scientific topics, including:

  • Melanoma and MAPK Pathways
  • PI3K/AKT/mTOR signaling in cancer
  • Cutaneous Melanoma Detection and Management
  • Cytokine Signaling Pathways and Interactions
  • Interferon and immune responses
  • Genomics, phytochemicals, and oxidative stress
  • Metal-Catalyzed Oxygenation Mechanisms

Dan Grandér authored multiple research articles, notable among them:

  • Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death, 2020, Science Advances
  • Ribonucleotide reductase inhibitors suppress SAMHD 1 ara- CTP ase activity enhancing cytarabine efficacy, 2020, EMBO Molecular Medicine
  • PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma, 2021, Scientific Reports
  • Silencing of CEBPB-AS1 modulates CEBPB expression and resensitizes BRAF-inhibitor resistant melanoma cells to vemurafenib, 2020, Melanoma Research
  • PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma, 2020, bioRxiv (Cold Spring Harbor Laboratory)

The researcher frequently collaborated with a group of coauthors, including:

  • Katja Pokrovskaja Tamm
  • Linda Vidarsdóttir
  • Alireza Azimi
  • Ingibjorg Sigvaldadottir
  • Ishani Das

Grandér published their research findings in venues such as Science Advances, EMBO Molecular Medicine, Scientific Reports, Melanoma Research, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Evolutionary conservation of long non-coding RNAs; sequence, structure, function.

    Per Johnsson;Leonard Lipovich;Dan Grandér;Kevin V. Morris;Kevin V. Morris

  • FBXW7/hCDC4 is a general tumor suppressor in human cancer

    Shahab Akhoondi;Dahui Sun;Natalie von der Lehr;Sophia Apostolidou

  • A pseudogene long noncoding RNA network regulates PTEN transcription and translation in human cells

    Per Johnsson;Amanda Ackley;Linda Vidarsdottir;Weng-Onn Lui

  • LUMA (LUminometric Methylation Assay)--a high throughput method to the analysis of genomic DNA methylation.

    Mohsen Karimi;Sofia Johansson;Dirk Stach;Martin Corcoran

  • Mechanisms of Interferon-alpha induced apoptosis in malignant cells

    Lena Thyrell;Sven Erickson;Boris Zhivotovsky;Katja Pokrovskaja

  • Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia.

    Yie Liu;Martin Corcoran;Omid Rasool;Ganka Ivanova

  • Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

    E. Laane;K. Pokrovskaja Tamm;E. Buentke;K. Ito

  • Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid.

    Theoharis Panaretakis;Irina G. Shabalina;Dan Grandér;Maria C. Shoshan

  • MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and Invasion

    Ning Xu;Lingyun Zhang;Florian Meisgen;Masako Harada

  • DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

    Mikael Lerner;Masako Harada;Jakob Lovén;Juan Castro

  • Molecular mechanisms underlying interferon-α-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins

    Olle Sangfelt;Sven Erickson;Juan Castro;Thomas Heiden

  • Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.

    Theocharis Panaretakis;Katja Pokrovskaja;Maria C. Shoshan;Dan Grandér

  • PD-L1 is commonly expressed and transcriptionally regulated by STAT3 and MYC in ALK-negative anaplastic large-cell lymphoma.

    V Atsaves;N Tsesmetzis;D Chioureas;L Kis;L Kis

  • Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines

    O Sangfelt;S Erickson;J Castro;T Heiden

  • Interferon α-induced Apoptosis in Tumor Cells Is Mediated through the Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Signaling Pathway

    Lena Thyrell;Linn Hjortsberg;Velmurugesan Arulampalam;Theocharis Panaretakis

  • Induction of Cip/Kip and Ink4 cyclin dependent kinase inhibitors by interferon-alpha in hematopoietic cell lines.

    Olle Sangfelt;Sven Erickson;Stefan Einhorn;Dan Grandér

  • Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas

    Lu Liu;L. Magnus Bäcklund;Bo R. Nilsson;Dan Grandér

  • 6q Deletions in Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphomas

    Mats Merup;Teresa Calero Moreno;Teresa Calero Moreno;Mats Heyman;Mats Heyman;Kristina Rönnberg;Kristina Rönnberg

  • 13Q DELETIONS IN LYMPHOID MALIGNANCIES

    Yie Liu;Monica Hermanson;Dan Grander;Mats Merup

  • Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: Evidence for a role of an adjacent locus

    Yie Liu;Laszlo Szekely;Dan Grander;Stefan Soderhall

Frequent Co-Authors

Theocharis Panaretakis
Theocharis Panaretakis The University of Texas MD Anderson Cancer Center
Eugene R. Zabarovsky
Eugene R. Zabarovsky Karolinska Institute
David Oscier
David Oscier Royal Bournemouth Hospital
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Gunnar Juliusson
Gunnar Juliusson Lund University
Angelo De Milito
Angelo De Milito Karolinska Institute
Ann Nordgren
Ann Nordgren Karolinska University Hospital
Kevin V. Morris
Kevin V. Morris City of Hope
Johan Hansson
Johan Hansson Karolinska Institute
Catharina Larsson
Catharina Larsson Karolinska University Hospital

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