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Alison E. Ashcroft

Alison E. Ashcroft

D-Index & Metrics

Chemistry

D-Index
54
Citations
8234
World Ranking
12835
National Ranking
721

Overview

Alison E. Ashcroft is affiliated with the University of Leeds in the United Kingdom. Their research spans multiple fields, primarily within biochemistry, genetics, and molecular biology, as well as chemistry. They have contributed to subfields including molecular biology, spectroscopy, radiology, nuclear medicine and imaging, genetics, and analytical chemistry.

The scientist's research topics cover a range of areas such as protein structure and dynamics, monoclonal and polyclonal antibodies research, protein purification and stability, mass spectrometry techniques and applications, bacterial genetics and biotechnology, viral infectious diseases and gene expression in insects, and heat shock proteins research.

Alison E. Ashcroft has authored significant papers, including:

  • "Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients" (2020, Nature Communications)
  • "An in vivo platform to select and evolve aggregation-resistant proteins" (2020, Nature Communications)
  • "Mass Spectrometry Characterization of Higher Order Structural Changes Associated with the Fc-glycan Structure of the NISTmAb Reference Material, RM 8761" (2020, Journal of the American Society for Mass Spectrometry)
  • "Validation of ion mobility spectrometry - mass spectrometry as a screening tool to identify type II kinase inhibitors of FGFR1 kinase" (2021, Rapid Communications in Mass Spectrometry)
  • "Investigation of D76N β2-Microglobulin Using Protein Footprinting and Structural Mass Spectrometry" (2021, Journal of the American Society for Mass Spectrometry)

Frequent co-authors associated with Ashcroft's work include:

  • Sheena E. Radford
  • Bob Schiffrin
  • David J. Brockwell
  • Antonio N. Calabrese
  • Matthew A. Watson

Their publications have appeared repeatedly in journals such as Nature Communications, Journal of the American Society for Mass Spectrometry, Rapid Communications in Mass Spectrometry, Analytical Chemistry, and materials affiliated with the University of Leeds.

Alison E. Ashcroft has contributed to book literature as well, notably publishing with the Royal Society of Chemistry. One known book is Ion Mobility-Mass Spectrometry (2021), which has been cited in subsequent scholarly works.

Best Publications

  • Deciphering drift time measurements from travelling wave ion mobility spectrometry-mass spectrometry studies

    David P. Smith;Tom W. Knapman;Iain Campuzano;Richard W. Malham

  • Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry

    Lydia M. Young;Janet C. Saunders;Rachel A. Mahood;Charlotte H. Revill

  • Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM.

    Matthew G. Iadanza;Anna J. Higgins;Bob Schiffrin;Antonio N. Calabrese

  • N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

    Lijuan Kang;Gina M. Moriarty;Lucy A. Woods;Alison E. Ashcroft

  • Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism

    Han Remaut;Rebecca J. Rose;Thomas J. Hannan;Scott J. Hultgren

  • Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors.

    Lydia M. Young;Ping Cao;Daniel P. Raleigh;Alison E. Ashcroft

  • Elongated oligomers in β2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry

    David P. Smith;Sheena E. Radford;Alison E. Ashcroft

  • Direct observation of oligomeric species formed in the early stages of amyloid fibril formation using electrospray ionisation mass spectrometry.

    Andrew M. Smith;Thomas R. Jahn;Alison E. Ashcroft;Sheena E. Radford

  • Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein.

    David R. Taylor;Edward T. Parkin;Sarah L. Cocklin;James R. Ault

  • Widespread, routine occurrence of pharmaceuticals in sewage effluent, combined sewer overflows and receiving waters.

    Paul Kay;Stephen R. Hughes;James R. Ault;Alison E. Ashcroft

  • Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry.

    David P. Smith;Kevin Giles;Robert H. Bateman;Sheena E. Radford

  • Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

    Lucy A Woods;Geoffrey W Platt;Andrew L Hellewell;Eric W Hewitt

  • The Effect of Dimethylbiguanide on Thrombin Activity, FXIII Activation, Fibrin Polymerization, and Fibrin Clot Formation

    Kristina F. Standeven;Robert A.S. Ariëns;Paul Whitaker;Alison E. Ashcroft

  • Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

    Claire L. Dobson;Paul W. A. Devine;Jonathan J. Phillips;Daniel R. Higazi

  • Inducing protein aggregation by extensional flow

    John Dobson;Amit Kumar;Leon F Willis;Roman Tuma

  • Advances in ion mobility spectrometry-mass spectrometry reveal key insights into amyloid assembly.

    L.A. Woods;S.E. Radford;A.E. Ashcroft

  • Determining the topology of virus assembly intermediates using ion mobility spectrometry–mass spectrometry

    Tom W. Knapman;Victoria L. Morton;Nicola J. Stonehouse;Peter G. Stockley

  • Skp is a multivalent chaperone of outer-membrane proteins

    Bob Schiffrin;Antonio N Calabrese;Paul W A Devine;Sarah A Harris

  • Considerations in experimental and theoretical collision cross-section measurements of small molecules using travelling wave ion mobility spectrometry-mass spectrometry

    Tom W. Knapman;Joshua T. Berryman;Iain Campuzano;Sarah A. Harris

  • 5-Methylthiopentose: a new substituent on lipoarabinomannan in Mycobacterium tuberculosis

    Achim Treumann;Feng Xidong;Liam McDonnell;Peter J Derrick

Frequent Co-Authors

Sheena E. Radford
Sheena E. Radford University of Leeds
Peter G. Stockley
Peter G. Stockley University of Leeds
Gabriel Waksman
Gabriel Waksman University College London
Christopher Exley
Christopher Exley Keele University
Peter J. F. Henderson
Peter J. F. Henderson University of Leeds
Daniel P. Raleigh
Daniel P. Raleigh Stony Brook University
Neil M. Ferguson
Neil M. Ferguson Imperial College London
Scott J. Hultgren
Scott J. Hultgren Washington University in St. Louis
Carol V. Robinson
Carol V. Robinson University of Oxford
Jutta Rieger
Jutta Rieger Sorbonne University

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