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Biology and Biochemistry

D-Index
45
Citations
7073
World Ranking
19138
National Ranking
7818

Overview

Debra K. Newman is affiliated with the Medical College of Wisconsin in the United States. Their academic work centers predominantly in the field of Medicine, with a specialized focus on Hematology, Immunology and Allergy, Genetics, Immunology, and Insect Science as subfields.

Their research topics include:

  • Platelet Disorders and Treatments
  • Cell Adhesion Molecules Research
  • Blood groups and transfusion
  • Blood disorders and treatments
  • Complement system in diseases
  • Autoimmune Bullous Skin Diseases
  • Insect symbiosis and bacterial influences

Newman has contributed to various prominent publication venues, with significant outputs in:

  • Blood (6 publications)
  • Arteriosclerosis Thrombosis and Vascular Biology (1 publication)
  • Blood Advances (1 publication)
  • Pediatric Blood & Cancer (1 publication)
  • Human Immunology (1 publication)

Frequent collaborators in Newman's research include:

  • Peter J. Newman (8 co-authored works)
  • Huiying Zhi (6 co-authored works)
  • Douglas Sheridan (2 co-authored works)
  • Danying Liao (1 co-authored work)
  • Jesse A. Sundlov (1 co-authored work)

Selected recent papers authored or co-authored by Newman are:

  • "Atomic Level Dissection of the Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) Homophilic Binding Interface: Implications for Endothelial Cell Barrier Function," 2021, Arteriosclerosis Thrombosis and Vascular Biology
  • "Prophylactic administration of HPA-1a-specific antibodies prevents fetal/neonatal alloimmune thrombocytopenia in mice," 2022, Blood
  • "Preclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia," 2021, Blood Advances
  • "Does anti-HPA-1a affect birthweight in fetal and neonatal alloimmune thrombocytopenia?" 2024, Pediatric Blood & Cancer
  • "Antigen-specific immunotherapy for platelet alloimmune disorders," 2024, Human Immunology

Best Publications

  • Signal Transduction Pathways Mediated by PECAM-1: New Roles for an Old Molecule in Platelet and Vascular Cell Biology

    Peter J. Newman;Debra K. Newman

  • Molecular Cloning, Chromosomal Localization, Tissue Distribution, and Functional Expression of the Human Pancreatic Sodium Bicarbonate Cotransporter

    Natalia Abuladze;Ivan Lee;Debra Newman;James Hwang

  • Cloning, Tissue Distribution, Genomic Organization, and Functional Characterization of NBC3, a New Member of the Sodium Bicarbonate Cotransporter Family*

    Alexander Pushkin;Natalia Abuladze;Ivan Lee;Debra Newman

  • Identification of FcγRIIa as the ITAM-bearing receptor mediating αIIbβ3 outside-in integrin signaling in human platelets

    Brian Boylan;Cunji Gao;Vipul Rathore;Joan C. Gill

  • Platelet PECAM-1 inhibits thrombus formation in vivo

    Shahrokh Falati;Sonali Patil;Peter L. Gross;Michelle Stapleton

  • PECAM-1: Conflicts of interest in inflammation

    Jamie R. Privratsky;Debra K. Newman;Peter J. Newman

  • Anti-GPVI–associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRγ-chain complex from the human platelet surface

    Brian Boylan;Hong Chen;Vipul Rathore;Cathy Paddock

  • Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen.

    Sonali Patil;Debra K. Newman;Peter J. Newman

  • High-throughput phosphotyrosine profiling using SH2 domains.

    Kazuya Machida;Christopher M. Thompson;Kevin Dierck;Karl Jablonowski

  • Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck).

    Debra K. Newman;Christin Hamilton;Christin Hamilton;Peter J. Newman;Peter J. Newman

  • PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis.

    Cunji Gao;Weiyong Sun;Melpo Christofidou-Solomidou;Motoshi Sawada

  • Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling

    Cunji Gao;Brian Boylan;Juan Fang;David A. Wilcox

  • Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity.

    Jamie R. Privratsky;Cathy M. Paddock;Oliver Florey;Debra K. Newman;Debra K. Newman

  • Structural organization of the human NBC1 gene: kNBC1 is transcribed from an alternative promoter in intron 3.

    Natalia Abuladze;Mark Song;Alexander Pushkin;Debra Newman

  • Endothelial cell PECAM-1 confers protection against endotoxic shock

    Matthias Maas;Michelle Stapleton;Carmen Bergom;David L. Mattson

  • Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family.

    Alexander Pushkin;Natalia Abuladze;Debra Newman;Ivan Lee

  • Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor–Deficient Mice

    Reema Goel;Benjamin R. Schrank;Shikha Arora;Brian Boylan

  • Structural characterization, tissue distribution, and functional expression of murine aminoacylase III

    Alexander Pushkin;Gerardo Carpenito;Natalia Abuladze;Debra Newman

  • Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.

    Huiying Zhi;Lubica Rauova;Vincent Hayes;Cunji Gao

  • Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcγRIIa and the integrin β3 cytoplasmic domain

    Cunji Gao;Brian Boylan;Dan Bougie;Joan C. Gill

Frequent Co-Authors

Peter J. Newman
Peter J. Newman Medical College of Wisconsin
Ira Kurtz
Ira Kurtz University of California, Los Angeles
Demin Wang
Demin Wang Medical College of Wisconsin
Pippa Simpson
Pippa Simpson Medical College of Wisconsin
Balaraman Kalyanaraman
Balaraman Kalyanaraman Medical College of Wisconsin
Mortimer Poncz
Mortimer Poncz Children's Hospital of Philadelphia
Howard F. Jenkinson
Howard F. Jenkinson University of Bristol
Richard H. Aster
Richard H. Aster Medical College of Wisconsin
Robert R. Montgomery
Robert R. Montgomery Medical College of Wisconsin
Lawrence F. Brass
Lawrence F. Brass University of Pennsylvania

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