World's Best Scientists 2026 revealed!

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Neuroscience

D-Index
51
Citations
14380
World Ranking
5444
National Ranking
2424

Overview

John A. Wemmie is affiliated with the University of Iowa in the United States. Their research spans multiple areas in medicine, neuroscience, and biochemistry, genetics, and molecular biology, reflecting a multidisciplinary approach to understanding brain function and psychiatric conditions.

The scientist has contributed extensively to the fields of psychiatry and mental health, molecular biology, cognitive neuroscience, genetics, as well as radiology, nuclear medicine, and imaging. Their work particularly focuses on topics including bipolar disorder and its treatment, neuroscience and neuropharmacology research, epigenetics and DNA methylation, functional brain connectivity studies, advanced neuroimaging techniques and applications, genetics and neurodevelopmental disorders, and suicide and self-harm studies.

Notable recent papers demonstrating this breadth include:

  • "A human amygdala site that inhibits respiration and elicits apnea in pediatric epilepsy" (2020, JCI Insight)
  • "Metabolic abnormalities in the basal ganglia and cerebellum in bipolar disorder: A multi-modal MR study" (2022, Journal of Affective Disorders)
  • "Failure to breathe persists without air hunger or alarm following amygdala seizures" (2023, JCI Insight)
  • "Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice" (2020, Headache The Journal of Head and Face Pain)
  • "Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder" (2023, Neuropsychopharmacology)

John A. Wemmie frequently collaborates with several other researchers in their studies. Regular coauthors include Vincent A. Magnotta, Aislinn Williams, Jess G. Fiedorowicz, Jenny Gringer Richards, and Marie E. Gaine.

The scientist's research is often published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Affective Disorders, Biological Psychiatry, Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine Scientific Meeting and Exhibition, and JCI Insight.

Best Publications

  • Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

    Zhi-Gang Xiong;Xiao-Man Zhu;Xiang-Ping Chu;Manabu Minami

  • The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.

    John A. Wemmie;Jianguo Chen;Jianguo Chen;Candice C. Askwith;Candice C. Askwith;Alesia M. Hruska-Hageman;Alesia M. Hruska-Hageman

  • Acid-sensing ion channels in pain and disease

    John A. Wemmie;Rebecca J. Taugher;Collin J. Kreple

  • Acid-sensing ion channels: advances, questions and therapeutic opportunities

    John A. Wemmie;John A. Wemmie;Margaret P. Price;Michael J. Welsh

  • Acid-Sensing Ion Channel 1 Is Localized in Brain Regions with High Synaptic Density and Contributes to Fear Conditioning

    John A. Wemmie;Candice C. Askwith;Ejvis Lamani;Martin D. Cassell

  • Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.

    Kathleen A Sluka;Margaret P Price;Nicole M Breese;Cheryl L Stucky

  • The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior

    Adam E. Ziemann;Jason E. Allen;Nader S. Dahdaleh;Iuliia I. Drebot

  • Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system.

    Manuel A Friese;Matthew J Craner;Ruth Etzensperger;Sandra Vergo

  • Fear and panic in humans with bilateral amygdala damage.

    Justin S Feinstein;Colin Buzza;Rene Hurlemann;Rene Hurlemann;Robin L Follmer

  • A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein.

    M.S. Szczypka;J.A. Wemmie;W.S. Moye-Rowley;D.J. Thiele

  • Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons

    Christopher J. Benson;Jinghui Xie;John A. Wemmie;Margaret P. Price

  • Seizure termination by acidosis depends on ASIC1a

    Adam E Ziemann;Mikael K Schnizler;Gregory W Albert;Meryl A Severson

  • Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function

    A J Page;S M Brierley;C M Martin;M P Price

  • Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala

    Jianyang Du;Leah R. Reznikov;Margaret P. Price;Xiang-ming Zha

  • Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1.

    J A Wemmie;M S Szczypka;D J Thiele;W S Moye-Rowley

  • Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons.

    Candice C. Askwith;John A. Wemmie;John A. Wemmie;Margaret P. Price;Tania Rokhlina

  • Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.

    John A. Wemmie;Matthew W. Coryell;Candice C. Askwith;Ejvis Lamani

  • Yeast bZip proteins mediate pleiotropic drug and metal resistance.

    A Wu;J A Wemmie;N P Edgington;M Goebl

  • Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation

    Brian J. Dlouhy;Brian K. Gehlbach;Collin J. Kreple;Hiroto Kawasaki

  • Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines

    Xiang-ming Zha;John A. Wemmie;Steven H. Green;Michael J. Welsh

  • Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity

    Collin J Kreple;Yuan Lu;Rebecca J Taugher;Andrea L Schwager-Gutman

  • Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine.

    Ana Recober;Adisa Kuburas;Zhongming Zhang;John A. Wemmie

Frequent Co-Authors

Vincent A. Magnotta
Vincent A. Magnotta University of Iowa
Matthew A. Howard
Matthew A. Howard University of Iowa
Ryan T. LaLumiere
Ryan T. LaLumiere University of Iowa
George B. Richerson
George B. Richerson University of Iowa
John H. Freeman
John H. Freeman University of Iowa
Stuart M. Brierley
Stuart M. Brierley Flinders University
Andrew A. Pieper
Andrew A. Pieper University of Iowa
Hiroyuki Oya
Hiroyuki Oya University of Iowa
Hiroto Kawasaki
Hiroto Kawasaki University of Iowa
Daniel Tranel
Daniel Tranel University of Iowa

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Exploring these online programs can help neuroscience students and graduates expand their professional horizons and adapt to the evolving demands of health and human services fields.

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