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Immunology

D-Index
72
Citations
22674
World Ranking
2188
National Ranking
55

Overview

Alfred Zippelius is affiliated with the University Hospital of Basel in Switzerland and is active in the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Their research output includes a significant focus on Oncology, Immunology, Molecular Biology, Pulmonary and Respiratory Medicine, and Cancer Research.

The main research topics covered by their work include Cancer Immunotherapy and Biomarkers, CAR-T cell therapy research, Immunotherapy and Immune Responses, Immune Cell Function and Interaction, Immune cells in cancer, Lung Cancer Treatments and Mutations, and Cancer, Hypoxia, and Metabolism.

Some recent papers authored by Alfred Zippelius include:

  • CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors, 2020, Nature Immunology
  • Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion, 2020, Nature Immunology
  • SAKK 16/14: Durvalumab in Addition to Neoadjuvant Chemotherapy in Patients With Stage IIIA(N2) Non-Small-Cell Lung Cancer-A Multicenter Single-Arm Phase II Trial, 2021, Journal of Clinical Oncology
  • An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer, 2021, Nature Medicine
  • Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy, 2021, Nature

Frequent co-authors collaborating with Alfred Zippelius include Heinz Läubli, Nicole Kirchhammer, Marcel P. Trefny, Petra Herzig, and Mélanie Buchi.

Their publications are commonly found in several notable venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal for ImmunoTherapy of Cancer
  • Regular and Young Investigator Award Abstracts
  • Frontiers in Immunology
  • Journal of Clinical Oncology

Best Publications

  • A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

    Daniela S. Thommen;Daniela S. Thommen;Viktor H. Koelzer;Petra Herzig;Andreas Roller

  • RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types.

    Gianni Monaco;Gianni Monaco;Gianni Monaco;Bernett Lee;Weili Xu;Seri Mustafah

  • Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

    Christopher S. Garris;Sean P. Arlauckas;Rainer H. Kohler;Marcel P. Trefny

  • CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

    Haiping Wang;Fabien Franco;Yao Chen Tsui;Xin Xie

  • Disturbed mitochondrial dynamics in CD8 + TILs reinforce T cell exhaustion

    Yi-Ru Yu;Yi-Ru Yu;Hana Imrichova;Haiping Wang;Haiping Wang;Tung Chao;Tung Chao

  • Four functionally distinct populations of human effector-memory CD8+ T lymphocytes.

    Pedro Romero;Alfred Zippelius;Alfred Zippelius;Isabel Kurth;Mikaël J. Pittet;Mikaël J. Pittet

  • Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance

    Alfred Zippelius;Pascal Batard;Verena Rubio-Godoy;Gilles Bioley

  • Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin

    Laura Strauss;Laura Strauss;Theresa L. Whiteside;Ashley Knights;Christoph Bergmann

  • Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors

    Daniela Stefanie Thommen;Jens Schreiner;Philipp Müller;Petra Herzig

  • Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer.

    Fiamma Berner;David Bomze;Stefan Diem;Omar Hasan Ali

  • Limitations of reverse-transcriptase polymerase chain reaction analyses for detection of micrometastatic epithelial cancer cells in bone marrow.

    A Zippelius;P Kufer;G Honold;M W Köllermann

  • Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade.

    Philipp Müller;Matthias Kreuzaler;Tarik Khan;Daniela S. Thommen;Daniela S. Thommen

  • Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma

    Heinz Läubli;Heinz Läubli;Cathrin Balmelli;Matthias Bossard;Otmar Pfister

  • The immune system and cancer evasion strategies: therapeutic concepts

    S. Muenst;H. Läubli;H. Läubli;S. D. Soysal;A. Zippelius;A. Zippelius

  • An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer.

    Paula Voabil;Marjolein de Bruijn;Lisanne M. Roelofsen;Sanne H. Hendriks;Sanne H. Hendriks

  • Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

    Ana Luísa Correia;Ana Luísa Correia;Ana Luísa Correia;Joao C. Guimaraes;Joao C. Guimaraes;Priska Auf der Maur;Priska Auf der Maur;Duvini De Silva;Duvini De Silva;Duvini De Silva

  • Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

    Michal A. Stanczak;Shoib S. Siddiqui;Marcel P. Trefny;Daniela S. Thommen

  • Phenotypic Characteristics of Cell Lines Derived from Disseminated Cancer Cells in Bone Marrow of Patients with Solid Epithelial Tumors: Establishment of Working Models for Human Micrometastases

    Elmar Putz;Klaus Witter;Sonja Offner;Peter Stosiek

  • Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.

    Christina Claus;Claudia Ferrara;Wei Xu;Johannes Sam

  • Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer

    Alexandros Papachristofilou;Madeleine M. Hipp;Ute Klinkhardt;Martin Früh

  • Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions.

    Nathalie Rufer;Alfred Zippelius;Pascal Batard;Mikaël J. Pittet

  • Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma.

    Pedro Romero;Danila Valmori;Mikael J. Pittet;Alfred Zippelius

Frequent Co-Authors

Mikael J. Pittet
Mikael J. Pittet University of Geneva
Pedro Romero
Pedro Romero University of Lausanne
Daniel E. Speiser
Daniel E. Speiser University of Lausanne
Lukas Bubendorf
Lukas Bubendorf University Hospital of Basel
Jean-Charles Cerottini
Jean-Charles Cerottini University of Lausanne
Alexander Knuth
Alexander Knuth University of Zurich
Walter Weder
Walter Weder University of Zurich
Solange Peters
Solange Peters University Hospital of Lausanne
Danila Valmori
Danila Valmori University of Nantes
Philippe Guillaume
Philippe Guillaume University of Lausanne

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