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Microbiology

D-Index
63
Citations
23269
World Ranking
2673
National Ranking
1075

Overview

Pradeep K. Singh is affiliated with the University of Washington in the United States. Their research focuses primarily on the intersection of medicine and biochemistry, genetics, and molecular biology, with extensive contributions spanning several key subfields including pulmonary and respiratory medicine, molecular biology, emergency medical services, epidemiology, and molecular medicine.

Singh's work prominently addresses topics related to cystic fibrosis research advances, pediatric health and respiratory diseases, inhalation and respiratory drug delivery, neonatal respiratory health research, antibiotic resistance in bacteria, bacterial biofilms and quorum sensing, and genomics and phylogenetic studies.

Among Singh's recent publications are:

  • "Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist," 2023, Journal of Clinical Investigation
  • "PROMISE: Working with the CF community to understand emerging clinical and research needs for those treated with highly effective CFTR modulator therapy," 2021, Journal of Cystic Fibrosis
  • "Combining Ivacaftor and Intensive Antibiotics Achieves Limited Clearance of Cystic Fibrosis Infections," 2021, mBio
  • "The Depletion Mechanism Actuates Bacterial Aggregation by Exopolysaccharides and Determines Species Distribution & Composition in Bacterial Aggregates," 2022, Frontiers in Cellular and Infection Microbiology
  • "Elexacaftor/tezacaftor/ivacaftor's effects on cystic fibrosis infections are maintained, but not increased, after 3.5 years of treatment," 2024, Journal of Clinical Investigation

Singh has frequently published in a core set of academic journals, with the largest number of articles appearing in the Journal of Cystic Fibrosis. Other notable venues include the Annals of the American Thoracic Society, mBio, American Journal of Respiratory and Critical Care Medicine, and Journal of Clinical Investigation.

  • Journal of Cystic Fibrosis
  • Annals of the American Thoracic Society
  • mBio
  • American Journal of Respiratory and Critical Care Medicine
  • Journal of Clinical Investigation

Collaborations have been an important aspect of Singh's research activities. Frequent co-authors include Sarah J. Morgan, David P. Nichols, S. Durfey, Matthew C. Radey, and Stephen J. Salipante, reflecting close ties with experts contributing across cystic fibrosis and respiratory medicine.

  • Sarah J. Morgan
  • David P. Nichols
  • S. Durfey
  • Matthew C. Radey
  • Stephen J. Salipante

Singh's body of work is situated at the interface of clinical and molecular research, particularly in respiratory diseases and cystic fibrosis. Their scholarly output contributes to a better understanding of disease mechanisms, therapeutic interventions, and pathogen dynamics within pulmonary contexts.

Best Publications

  • Bacterial Biofilms: An Emerging Link to Disease Pathogenesis

    Matthew R. Parsek;Pradeep K. Singh

  • Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

    Pradeep K. Singh;Amy L. Schaefer;Matthew R. Parsek;Thomas O. Moninger

  • A component of innate immunity prevents bacterial biofilm development

    Pradeep K. Singh;Matthew R. Parsek;E. Peter Greenberg;E. Peter Greenberg;Michael J. Welsh;Michael J. Welsh;Michael J. Welsh

  • Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

    Dao Nguyen;Amruta Joshi-Datar;Francois Lepine;Elizabeth Bauerle

  • Self-generated diversity produces “insurance effects” in biofilm communities

    Blaise R. Boles;Matthew Thoendel;Pradeep K. Singh

  • The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity

    Yukihiro Kaneko;Matthew Thoendel;Oyebode Olakanmi;Bradley E. Britigan

  • Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.

    Mario Kratz;Mario Kratz;Brittney R. Coats;Katherine B. Hisert;Derek Hagman

  • Production of β-defensins by human airway epithelia

    Pradeep K. Singh;Hong Peng Jia;Kerry Wiles;Jay Hesselberth

  • Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange

    Laura R Hmelo;Bradley R Borlee;Henrik Almblad;Michelle E Love

  • Rhamnolipids mediate detachment of Pseudomonas aeruginosa from biofilms.

    Blaise R. Boles;Matthew Thoendel;Pradeep K. Singh

  • The extracellular matrix protects Pseudomonas aeruginosa biofilms by limiting the penetration of tobramycin.

    Boo Shan Tseng;Wei Zhang;Joe J. Harrison;Tam P. Quach

  • The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

    Alexander V. Birk;Shaoyi Liu;Yi Soong;William Mills

  • Cystic Fibrosis Sputum Supports Growth and Cues Key Aspects of Pseudomonas aeruginosa Physiology

    Kelli L. Palmer;Lauren M. Mashburn;Pradeep K. Singh;Marvin Whiteley

  • Endogenous oxidative stress produces diversity and adaptability in biofilm communities.

    Blaise R. Boles;Pradeep K. Singh

  • Synergistic and additive killing by antimicrobial factors found in human airway surface liquid

    Pradeep K. Singh;Brian F. Tack;Paul B. McCray;Michael J. Welsh;Michael J. Welsh

  • Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections

    Katherine B. Hisert;Sonya L. Heltshe;Christopher Pope;Peter Jorth

  • Direct sampling of cystic fibrosis lungs indicates that DNA-based analyses of upper-airway specimens can misrepresent lung microbiota

    Amanda F. Goddard;Benjamin J. Staudinger;Scot E. Dowd;Amruta Joshi-Datar

  • Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

    Christopher H. Goss;Yukihiro Kaneko;Lisa Khuu;Gail D. Anderson

  • Regional Isolation Drives Bacterial Diversification within Cystic Fibrosis Lungs.

    Peter Jorth;Benjamin J. Staudinger;Xia Wu;Katherine B. Hisert

  • Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

    Edouard Mullarky;Edouard Mullarky;Natasha C. Lucki;Reza Beheshti Zavareh;Justin L. Anglin

  • Delayed wound healing in diabetic (db/db) mice with Pseudomonas aeruginosa biofilm challenge: a model for the study of chronic wounds

    Ge Zhao;Phillip C. Hochwalt;Marcia L. Usui;Robert A. Underwood

  • Activity of abundant antimicrobials of the human airway

    Sue M. Travis;Barbara Ann D Conway;Joseph Zabner;Jeffrey J. Smith

Frequent Co-Authors

Michael J. Welsh
Michael J. Welsh University of Iowa
Colin Manoil
Colin Manoil University of Washington
Carl Nathan
Carl Nathan Cornell University
Vinod K. Singh
Vinod K. Singh Indian Institute of Technology Kanpur
James E. Bruce
James E. Bruce University of Washington
Matthew R. Parsek
Matthew R. Parsek University of Washington
Lei Shi
Lei Shi National Institute on Drug Abuse
E. P. Greenberg
E. P. Greenberg University of Washington
Paul B. McCray
Paul B. McCray University of Iowa
Anuradha Chowdhary
Anuradha Chowdhary University of Delhi

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