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Biology and Biochemistry

D-Index
66
Citations
25603
World Ranking
8458
National Ranking
619

Overview

Christian A. Hübner is affiliated with Friedrich Schiller University Jena in Germany, focusing on research at the intersection of biochemistry, genetics, molecular biology, medicine, and neuroscience. Their work spans main fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience, with emphasis on subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Cell Biology, and Genetics.

Their research topics cover a range of areas with notable attention to Neuroscience and Neuropharmacology Research, Ion Transport and Channel Regulation, Cellular Transport and Secretion, Autophagy in Disease and Therapy, Ion Channel Regulation and Function, Neuroinflammation and Neurodegeneration Mechanisms, and Hereditary Neurological Disorders.

Christian A. Hübner has contributed extensively to academic publications, with recent papers demonstrating their engagement in studying cellular mechanisms and disease processes. Some of their recent publications include:

  • Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms (2020, Nature)
  • Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum (2023, Nature)
  • Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control (2021, EMBO Reports)
  • MiT/ TFE factors control ER-phagy via transcriptional regulation of FAM 134B (2020, The EMBO Journal)
  • Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy (2023, Nature)

Their frequent co-authors include Patricia Franzka, Lutz Liebmann, Martin Ungelenk, Olivia Engmann, and Antje K. Huebner, reflecting ongoing collaborations in their research projects.

Christian A. Hübner has published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Brain, Frontiers in Molecular Neuroscience, Nature, and Cerebral Cortex, indicating a diverse range of scientific communication and dissemination channels.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Regulation of endoplasmic reticulum turnover by selective autophagy

    Aliaksandr Khaminets;Theresa Heinrich;Muriel Mari;Paolo Grumati

  • Disruption of KCC2 Reveals an Essential Role of K-Cl Cotransport Already in Early Synaptic Inhibition

    Christian A. Hübner;Valentin Stein;Irm Hermans-Borgmeyer;Torsten Meyer

  • Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

    Wouter van Rheenen;Aleksey Shatunov;Annelot M. Dekker;Russell L. McLaughlin

  • Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery.

    Roman Tyzio;Rosa Cossart;Ilgam Khalilov;Marat Minlebaev

  • Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4

    Thomas Boettger;Christian A. Hübner;Hannes Maier;Marco B. Rust

  • Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride.

    Valentin Stein;Irm Hermans-Borgmeyer;Thomas J. Jentsch;Christian A. Hübner

  • Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.

    Michael R. Bösl;Valentin Stein;Christian Hübner;Anselm A. Zdebik

  • A de novo gain-of-function mutation in SCN11A causes loss of pain perception

    Enrico Leipold;Lutz Liebmann;G Christoph Korenke;Theresa Heinrich

  • Ion channel diseases

    Christian A Hübner;Thomas J Jentsch

  • The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice

    Françoise Leviel;Christian A. Hübner;Pascal Houillier;Luciana Morla

  • Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy

    Andreas R Janecke;Debra A Thompson;Gerd Utermann;Christian Becker

  • Loss of K‐Cl co‐transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold

    Thomas Boettger;Thomas Boettger;Marco B. Rust;Hannes Maier;Thomas Seidenbecher

  • Ion channels: Function unravelled by dysfunction

    Thomas J Jentsch;Christian A Hübner;Jens C Fuhrmann

  • Mutations in **FAM134B**, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy

    Ingo Kurth;Torsten Pamminger;J Christopher Hennings;Désirée Soehendra

  • Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6

    Mallorie Poët;Uwe Kornak;Michaela Schweizer;Anselm A. Zdebik

  • Leukoencephalopathy upon disruption of the chloride channel ClC-2.

    Judith Blanz;Michaela Schweizer;Muriel Auberson;Muriel Auberson;Hannes Maier

  • Early expression of KCC2 in rat hippocampal cultures augments expression of functional GABA synapses

    Ilona Chudotvorova;Anton Ivanov;Sylvain Rama;Christian A. Hübner

  • Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

    Wouter van Rheenen;Rick A. A. van der Spek;Mark K. Bakker;Joke J. F. A. van Vugt

  • The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice (The Journal of Clinical Investigation (2011), 121, 4, (1668) DOI: 10.1172/JCI57722)

    Françoise Leviel;Christian A. Hübner;Pascal Houillier;Luciana Morla

Frequent Co-Authors

Thomas J. Jentsch
Thomas J. Jentsch Charité - University Medicine Berlin
Andreas Gal
Andreas Gal Universität Hamburg
Wolfgang Stremmel
Wolfgang Stremmel Heidelberg University
Peter Nürnberg
Peter Nürnberg University of Cologne
Britta Qualmann
Britta Qualmann Friedrich Schiller University Jena
Seth L. Alper
Seth L. Alper Beth Israel Deaconess Medical Center
Irm Hermans-Borgmeyer
Irm Hermans-Borgmeyer Universität Hamburg
Michaela Schweizer
Michaela Schweizer Universität Hamburg
Otto W. Witte
Otto W. Witte Friedrich Schiller University Jena
Roel A. Ophoff
Roel A. Ophoff University of California, Los Angeles

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