What is he best known for?
The fields of study he is best known for:
- Enzyme
- Amino acid
- Organic chemistry
Peptide synthesis, Peptide, Polystyrene, Biochemistry and Phase are his primary areas of study.
His Peptide synthesis research is multidisciplinary, incorporating perspectives in Protecting group, Coupling reaction, Organic chemistry, Solvent and Chromatography.
His Peptide research is multidisciplinary, incorporating elements of Epidermal growth factor and Ratón.
Solvation, Polymer, Swelling and Amino acid is closely connected to Polymer chemistry in his research, which is encompassed under the umbrella topic of Polystyrene.
R. B. Merrifield has included themes like Protein primary structure, Molecular cloning and Signal peptide in his Biochemistry study.
His research in Phase intersects with topics in Combinatorial chemistry and Polyethylene.
His most cited work include:
- Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction. (893 citations)
- An SN2 deprotection of synthetic peptides with a low concentration of hydrofluoric acid in dimethyl sulfide: evidence and application in peptide synthesis (544 citations)
- A new synthetic route to tert-butyloxycarbonylaminoacyl-4-(oxymethyl)phenylacetamidomethyl-resin, an improved support for solid-phase peptide synthesis (280 citations)
What are the main themes of his work throughout his whole career to date?
R. B. Merrifield mainly investigates Peptide synthesis, Peptide, Biochemistry, Organic chemistry and Stereochemistry.
His Peptide synthesis research includes elements of Combinatorial chemistry, Protecting group, Phase and Medicinal chemistry.
His research integrates issues of Peptidomimetic and Nucleophile in his study of Phase.
His research investigates the connection with Peptide and areas like Chromatography which intersect with concerns in Coupling reaction.
His work on Reagent, Trifluoroacetic acid and Alcohol is typically connected to Dimethyl sulfide as part of general Organic chemistry study, connecting several disciplines of science.
His study in the fields of Circular dichroism under the domain of Stereochemistry overlaps with other disciplines such as Amphiphile.
He most often published in these fields:
- Peptide synthesis (41.58%)
- Peptide (30.69%)
- Biochemistry (25.74%)
What were the highlights of his more recent work (between 2005-2010)?
- Peptide (30.69%)
- Solid-phase synthesis (9.90%)
- Stereochemistry (23.76%)
In recent papers he was focusing on the following fields of study:
His primary scientific interests are in Peptide, Solid-phase synthesis, Stereochemistry, Organic chemistry and Peptide synthesis.
His Peptide research is classified as research in Biochemistry.
His work carried out in the field of Solid-phase synthesis brings together such families of science as Side chain and Oligopeptide.
His Stereochemistry study incorporates themes from Melittin, Combinatorial chemistry, Yield and Residue.
R. B. Merrifield combines subjects such as Tetrapeptide and Medicinal chemistry with his study of Organic chemistry.
His Peptide synthesis study necessitates a more in-depth grasp of Amino acid.
Between 2005 and 2010, his most popular works were:
- Antibacterial peptides designed as analogs or hybrids of cecropins and melittin. (143 citations)
- SN 1 and SN 2 mechanisms for the deprotection of synthetic peptides by hydrogen fluoride. Studies to minimize the tyrosine alkylation side reaction. (80 citations)
- Weak acid-catalyzed pyrrolidone carboxylic acid formation from glutamine during solid phase peptide synthesis. Minimization by rapid coupling. (70 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Amino acid
- Organic chemistry
His primary areas of investigation include Peptide, Biochemistry, Cecropin, Oligopeptide and Biological activity.
R. B. Merrifield works in the field of Peptide, namely Tetrapeptide.
His Biochemistry study integrates concerns from other disciplines, such as Bacillus subtilis and Gram-positive bacteria.
As part of the same scientific family, he usually focuses on Cecropin, concentrating on Antibacterial agent and intersecting with Combinatorial chemistry.
The Combinatorial chemistry study combines topics in areas such as Side reaction and Organic chemistry, Carboxylic acid.
His studies in Oligopeptide integrate themes in fields like Melittin, Antibacterial activity and Solid-phase synthesis.
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