R. B. Merrifield

Research.com Recognitions

• 1986 - Centenary Prize, Royal Society of Chemistry (UK)
• 1984 - Nobel Prize for his development of methodology for chemical synthesis on a solid matrix
• 1973 - William H. Nichols Medal, American Chemical Society (ACS)
• 1970 - Canada Gairdner International Award

Overview

Best Publications

• Solid phase peptide synthesis. I. the synthesis of a tetrapeptide

  Unknown

  7206
  Citations

• Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction.

  Virender K. Sarin;Stephen B.H. Kent;James P. Tam;R.B. Merrifield

  1444
  Citations

• All-D amino acid-containing channel-forming antibiotic peptides.

  David Wade;Anita Boman;Birgitta Wahlin;C. M. Drain

  965
  Citations

• An SN2 deprotection of synthetic peptides with a low concentration of hydrofluoric acid in dimethyl sulfide: evidence and application in peptide synthesis

  James P. Tam;William F. Heath;R. B. Merrifield

  692
  Citations

• SOLID-PHASE PEPTIDE SYNTHESIS. 3. AN IMPROVED SYNTHESIS OF BRADYKININ.

  Unknown

  518
  Citations

• Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes.

  Unknown

  494
  Citations

• Automated synthesis of peptides.

  Unknown

  485
  Citations

• A new synthetic route to tert-butyloxycarbonylaminoacyl-4-(oxymethyl)phenylacetamidomethyl-resin, an improved support for solid-phase peptide synthesis

  Alexander R. Mitchell;Stephen B. H. Kent;Martin Engelhard;R. B. Merrifield

  462
  Citations

• Binding and action of cecropin and cecropin analogues: antibacterial peptides from insects.

  Håkan Steiner;David Andreu;R.B. Merrifield

  401
  Citations

• Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity.

  David Andreu;Josep Ubach;Anita Boman;Birgitta Wåhlin

  379
  Citations

• A NEW AMINO PROTECTING GROUP REMOVABLE BY REDUCTION. CHEMISTRY OF THE DITHIASUCCINOYL (DTS) FUNCTION

  G. Barany;R. B. Merrifield

  351
  Citations

• Solid Phase Synthesis (Nobel Lecture)

  Unknown

  322
  Citations

• Synthesis of the antibacterial peptide cecropin A (1-33).

  Unknown

  307
  Citations

• N-terminal analogues of cecropin A: synthesis, antibacterial activity, and conformational properties.

  David Andreu;R. B. Merrifield;Haakan Steiner;Hans G. Boman

  284
  Citations

• Mechanisms for the Removal of Benzyl Protecting Groups in Synthetic Peptides by Trifluoromethanesulfonic Acid - Trifluoroacetic Acid - Dimethyl Sulfide.

  J. P. Tam;W. F. Heath;R. B. Merrifield

  258
  Citations

• Synthesis of Angiotensins by the Solid-Phase Method*

  Garland R. Marshall;R. B. Merrifield

  252
  Citations

• The total synthesis of an enzyme with ribonuclease A activity.

  Unknown

  246
  Citations

• Properties of swollen polymer networks. Solvation and swelling of peptide-containing resins in solid-phase peptide synthesis

  Virender K. Sarin;Stephen B. H. Kent;R. B. Merrifield

  243
  Citations

• The synthesis of ribonuclease A.

  Unknown

  242
  Citations

• Solid-phase peptide synthesis.

  Unknown

  234
  Citations

• Antibacterial peptides designed as analogs or hybrids of cecropins and melittin.

  D. Wade;D. Andreu;S.A. Mitchell;A.M.V. Silveira

  223
  Citations

• Monitoring of solid phase peptide synthesis by an automated spectrophotometric picrate method.

  R.S. Hodges;R.B. Merrifield

  192
  Citations

• Molecular cloning, cDNA sequencing, and chemical synthesis of cecropin B from Hyalophora cecropia

  P van Hofsten;I Faye;K Kockum;J Y Lee

  190
  Citations

• Long-chain polystyrene-grafted polyethylene film matrix: a new support for solid-phase peptide synthesis

  Rolf H. Berg;Kristoffer Almdal;Walther Batsberg Pedersen;Arne Holm

  148
  Citations

• Acid stability of several benzylic protecting groups used in solid-phase peptide synthesis. Rearrangement of O-benzyltyrosine to 3-benzyltyrosine.

  Unknown

  145
  Citations

• Synthetic Melittin, Its Enantio, Retro, and Retroenantio Isomers, and Selected Chimeric Analogs: Their Antibacterial, Hemolytic, and Lipid Bilayer Action

  Padmaja Juvvadi;Satyanarayana Vunnam;R. B. Merrifield

  144
  Citations

• Preparation of aminomethyl-polystyrene resin by direct amidomethylation

  Alexander R. Mitchell;Stephen B.H. Kent;Bruce W. Erickson;R.B. Merrifield

  144
  Citations

• 3 – Solid-Phase Peptide Synthesis

  Bruce W. Erickson;R.B. Merrifield

  142
  Citations

• Characterization of Deletion and Truncation Mutants of the Rat Glucagon Receptor: SEVEN TRANSMEMBRANE SEGMENTS ARE NECESSARY FOR RECEPTOR TRANSPORT TO THE PLASMA MEMBRANE AND GLUCAGON BINDING (*)

  Cecilia G. Unson;Aaron M. Cypess;Hyang Nina Kim;Paul K. Goldsmith

  133
  Citations

• Position 9 replacement analogs of glucagon uncouple biological activity and receptor binding.

  C G Unson;D Macdonald;K Ray;T L Durrah

  125
  Citations

• SN 1 and SN 2 mechanisms for the deprotection of synthetic peptides by hydrogen fluoride. Studies to minimize the tyrosine alkylation side reaction.

  James P. Tam;William F. Heath;R.B. Merrifield

  125
  Citations

• A synthetic approach to structure-function relationships in the murine epidermal growth factor molecule

  William F. Heath;R. B. Merrifield

  120
  Citations