1986 - Centenary Prize, Royal Society of Chemistry (UK)
1984 - Nobel Prize for his development of methodology for chemical synthesis on a solid matrix
1973 - William H. Nichols Medal, American Chemical Society (ACS)
1970 - Canada Gairdner International Award
Peptide synthesis, Peptide, Polystyrene, Biochemistry and Phase are his primary areas of study. His Peptide synthesis research is multidisciplinary, incorporating perspectives in Protecting group, Coupling reaction, Organic chemistry, Solvent and Chromatography. His Peptide research is multidisciplinary, incorporating elements of Epidermal growth factor and Ratón.
Solvation, Polymer, Swelling and Amino acid is closely connected to Polymer chemistry in his research, which is encompassed under the umbrella topic of Polystyrene. R. B. Merrifield has included themes like Protein primary structure, Molecular cloning and Signal peptide in his Biochemistry study. His research in Phase intersects with topics in Combinatorial chemistry and Polyethylene.
R. B. Merrifield mainly investigates Peptide synthesis, Peptide, Biochemistry, Organic chemistry and Stereochemistry. His Peptide synthesis research includes elements of Combinatorial chemistry, Protecting group, Phase and Medicinal chemistry. His research integrates issues of Peptidomimetic and Nucleophile in his study of Phase.
His research investigates the connection with Peptide and areas like Chromatography which intersect with concerns in Coupling reaction. His work on Reagent, Trifluoroacetic acid and Alcohol is typically connected to Dimethyl sulfide as part of general Organic chemistry study, connecting several disciplines of science. His study in the fields of Circular dichroism under the domain of Stereochemistry overlaps with other disciplines such as Amphiphile.
His primary scientific interests are in Peptide, Solid-phase synthesis, Stereochemistry, Organic chemistry and Peptide synthesis. His Peptide research is classified as research in Biochemistry. His work carried out in the field of Solid-phase synthesis brings together such families of science as Side chain and Oligopeptide.
His Stereochemistry study incorporates themes from Melittin, Combinatorial chemistry, Yield and Residue. R. B. Merrifield combines subjects such as Tetrapeptide and Medicinal chemistry with his study of Organic chemistry. His Peptide synthesis study necessitates a more in-depth grasp of Amino acid.
His primary areas of investigation include Peptide, Biochemistry, Cecropin, Oligopeptide and Biological activity. R. B. Merrifield works in the field of Peptide, namely Tetrapeptide. His Biochemistry study integrates concerns from other disciplines, such as Bacillus subtilis and Gram-positive bacteria.
As part of the same scientific family, he usually focuses on Cecropin, concentrating on Antibacterial agent and intersecting with Combinatorial chemistry. The Combinatorial chemistry study combines topics in areas such as Side reaction and Organic chemistry, Carboxylic acid. His studies in Oligopeptide integrate themes in fields like Melittin, Antibacterial activity and Solid-phase synthesis.
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Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction.
Virender K. Sarin;Stephen B.H. Kent;James P. Tam;R.B. Merrifield.
Analytical Biochemistry (1981)
An SN2 deprotection of synthetic peptides with a low concentration of hydrofluoric acid in dimethyl sulfide: evidence and application in peptide synthesis
James P. Tam;William F. Heath;R. B. Merrifield.
Journal of the American Chemical Society (1983)
A new synthetic route to tert-butyloxycarbonylaminoacyl-4-(oxymethyl)phenylacetamidomethyl-resin, an improved support for solid-phase peptide synthesis
Alexander R. Mitchell;Stephen B. H. Kent;Martin Engelhard;R. B. Merrifield.
Journal of Organic Chemistry (1978)
N-terminal analogues of cecropin A: synthesis, antibacterial activity, and conformational properties.
David Andreu;R. B. Merrifield;Haakan Steiner;Hans G. Boman.
Mechanisms for the removal of benzyl protecting groups in synthetic peptides by trifluoromethanesulfonic acid-trifluoroacetic acid-dimethyl sulfide
J. P. Tam;W. F. Heath;R. B. Merrifield.
Journal of the American Chemical Society (1986)
Properties of swollen polymer networks. Solvation and swelling of peptide-containing resins in solid-phase peptide synthesis
Virender K. Sarin;Stephen B. H. Kent;R. B. Merrifield.
Journal of the American Chemical Society (1980)
Antibacterial peptides designed as analogs or hybrids of cecropins and melittin.
D. Wade;D. Andreu;S.A. Mitchell;A.M.V. Silveira.
International Journal of Peptide and Protein Research (2009)
Monitoring of solid phase peptide synthesis by an automated spectrophotometric picrate method.
R.S. Hodges;R.B. Merrifield.
Analytical Biochemistry (1975)
Molecular cloning, cDNA sequencing, and chemical synthesis of cecropin B from Hyalophora cecropia
P van Hofsten;I Faye;K Kockum;J Y Lee.
Proceedings of the National Academy of Sciences of the United States of America (1985)
Long-chain polystyrene-grafted polyethylene film matrix: a new support for solid-phase peptide synthesis
Rolf H. Berg;Kristoffer Almdal;Walther Batsberg Pedersen;Arne Holm.
Journal of the American Chemical Society (1989)
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