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D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
10895
World Ranking
16099
National Ranking
6672

Overview

Randolph Y. Hampton is affiliated with the University of California, San Diego in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a strong focus on Cell Biology and Molecular Biology as key subfields. Additional areas of interest include Surgery, Aging, and Genetics.

Their work extensively covers several main topics including Endoplasmic Reticulum Stress and Disease, Heat shock proteins research, Plant biochemistry and biosynthesis, Cholesterol and Lipid Metabolism, Cellular transport and secretion, Genetics, Aging, and Longevity in Model Organisms, and RNA Interference and Gene Delivery.

Randolph Y. Hampton has published multiple papers across various recognized scientific venues. Notable recent publications include:

  • HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation (2020), iScience
  • Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control (2020), Molecular Biology of the Cell
  • An autonomous, but INSIG-modulated, role for the sterol sensing domain in mallostery-regulated ERAD of yeast HMG-CoA reductase (2020), Journal of Biological Chemistry
  • Inner-nuclear-membrane-associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity (2021), Molecular Biology of the Cell
  • Exploring the "misfolding problem" by systematic discovery and analysis of functional-but-degraded proteins (2023), Molecular Biology of the Cell

Their frequent co-authors include Margaret A. Wangeline, Sonya E. Neal, Matthew P. Flagg, Della Syau, and Anahita Nejatfard. These collaborations have contributed to various publications across their research topics.

Randolph Y. Hampton's scientific contributions are found predominantly in the following publication venues:

  • Molecular Biology of the Cell
  • iScience
  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Recognition and plasma clearance of endotoxin by scavenger receptors.

    Randolph Y. Hampton;Douglas T. Golenbock;Marsha Penman;Monty Krieger

  • Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.

    Randolph Y. Hampton;Richard G. Gardner;Jasper Rine

  • ER-associated degradation in protein quality control and cellular regulation.

    Randolph Y Hampton

  • Hrd1p/Der3p is a membrane- anchored ubiquitin ligase required for ER-associated degradation

    Nathan W. Bays;Richard G. Gardner;Linda P. Seelig;Claudio A. Joazeiro

  • Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.

    D. T. Golenbock;R. Y. Hampton;N. Qureshi;K. Takayama

  • HRD4/NPL4 Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins

    Nathan W. Bays;Sharon K. Wilhovsky;Ami Goradia;Kelley Hodgkiss-Harlow

  • Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

    Richard G. Gardner;Gwendolyn M. Swarbrick;Nathan W. Bays;Stephen R. Cronin

  • Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

    Jarrod W. Heck;Samantha K. Cheung;Randolph Y. Hampton

  • Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae.

    K. A. G. Donald;R. Y. Hampton;I. B. Fritz

  • Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast.

    Randolph Y. Hampton;Jasper Rine

  • ER stress response: getting the UPR hand on misfolded proteins.

    Randolph Y. Hampton

  • Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase.

    Brian K. Sato;Daniel Schulz;Phong H. Do;Randolph Y. Hampton

  • Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis

    Stephen R. Cronin;Rajini Rao;Randolph Y. Hampton

  • Cdc48-Ufd1-Npl4: stuck in the middle with Ub.

    Nathan W Bays;Randolph Y Hampton

  • The biology of HMG-CoA reductase: the pros of contra-regulation

    Randolph Hampton;Dago Dimster-Denk;Jasper Rine

  • Control of the innate immune response by the mevalonate pathway

    Murali K Akula;Man Shi;Zhaozhao Jiang;Celia E Foster

  • Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase

    Randolph Y. Hampton;Hetal Bhakta

  • A Highly Conserved Signal Controls Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) Reductase in Eukaryotes

    Richard G. Gardner;Randolph Y. Hampton

  • Finding the will and the way of ERAD substrate retrotranslocation

    Randolph Y Hampton;Thomas Sommer;Thomas Sommer

  • Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle

    Daniel Finley;Keiji Tanaka;Carl Mann;Horst Feldmann

Frequent Co-Authors

Jasper Rine
Jasper Rine University of California, Berkeley
Douglas T. Golenbock
Douglas T. Golenbock University of Massachusetts Chan Medical School
Thomas Sommer
Thomas Sommer Max Delbrück Center for Molecular Medicine
James H. Woods
James H. Woods University of Michigan–Ann Arbor
David Ron
David Ron University of Cambridge
Christian R. H. Raetz
Christian R. H. Raetz Duke University
Ronald W. Holz
Ronald W. Holz University of Michigan–Ann Arbor
Christopher Benner
Christopher Benner University of California, San Diego
Trey Ideker
Trey Ideker University of California, San Diego
Breck Byers
Breck Byers University of Washington

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