What is he best known for?
The fields of study he is best known for:
His main research concerns Cell biology, Biochemistry, Ubiquitin, Endoplasmic-reticulum-associated protein degradation and Endoplasmic reticulum.
Randolph Y. Hampton combines subjects such as JUNQ and IPOD and Ubiquitin ligase with his study of Cell biology.
His study in the field of Reductase, Macrophage and Cell surface receptor also crosses realms of Scavenger receptor binding and Lipid A.
His Reductase study combines topics in areas such as Integral membrane protein and Saccharomyces cerevisiae.
As a member of one scientific family, Randolph Y. Hampton mostly works in the field of Endoplasmic-reticulum-associated protein degradation, focusing on Membrane protein and, on occasion, Transmembrane domain, Function, Protein ubiquitination and Ubiquitins.
His Endoplasmic reticulum research is multidisciplinary, incorporating perspectives in Nucleocytoplasmic Transport Proteins, Nuclear protein, Nuclear transport, Cell nucleus and Fungal protein.
His most cited work include:
- Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. (487 citations)
- Recognition and plasma clearance of endotoxin by scavenger receptors. (473 citations)
- Hrd1p/Der3p is a membrane- anchored ubiquitin ligase required for ER-associated degradation (412 citations)
What are the main themes of his work throughout his whole career to date?
Randolph Y. Hampton spends much of his time researching Cell biology, Biochemistry, Endoplasmic reticulum, Endoplasmic-reticulum-associated protein degradation and Ubiquitin.
His Cell biology study combines topics from a wide range of disciplines, such as Ubiquitin-Protein Ligases and Membrane protein.
His Biochemistry study is mostly concerned with Reductase, Mevalonate pathway, Saccharomyces cerevisiae, Protein degradation and HMG-CoA reductase.
His Endoplasmic reticulum research is multidisciplinary, incorporating elements of Integral membrane protein, Sterol regulatory element-binding protein, Gene and Geranylgeranyl pyrophosphate.
Randolph Y. Hampton interconnects Substrate and Sterol in the investigation of issues within Endoplasmic-reticulum-associated protein degradation.
His Ubiquitin study incorporates themes from Cytosol, Plasma protein binding and Proteasome.
He most often published in these fields:
- Cell biology (54.12%)
- Biochemistry (47.06%)
- Endoplasmic reticulum (37.65%)
What were the highlights of his more recent work (between 2015-2021)?
- Cell biology (54.12%)
- Endoplasmic-reticulum-associated protein degradation (35.29%)
- Protein folding (14.12%)
In recent papers he was focusing on the following fields of study:
Randolph Y. Hampton mainly investigates Cell biology, Endoplasmic-reticulum-associated protein degradation, Protein folding, Ubiquitin and Endoplasmic reticulum.
His work deals with themes such as Biochemistry, Allosteric regulation, AIM2 and Mevalonate kinase, which intersect with Cell biology.
His Endoplasmic-reticulum-associated protein degradation study frequently draws connections between related disciplines such as Proteasome.
His Protein folding study integrates concerns from other disciplines, such as Sterol and Protein quality.
His study in Ubiquitin is interdisciplinary in nature, drawing from both Reductase, Mutant and Cytosol.
As part of one scientific family, he deals mainly with the area of Endoplasmic reticulum, narrowing it down to issues related to the Integral membrane protein, and often Transport protein and Protein degradation.
Between 2015 and 2021, his most popular works were:
- Control of the innate immune response by the mevalonate pathway (100 citations)
- The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins (43 citations)
- Direct and essential function for Hrd3 in ER-associated degradation. (35 citations)
In his most recent research, the most cited papers focused on:
His scientific interests lie mostly in Endoplasmic-reticulum-associated protein degradation, Cell biology, Protein folding, Endoplasmic reticulum and Ubiquitin.
His Endoplasmic-reticulum-associated protein degradation research entails a greater understanding of Genetics.
His Cell biology research incorporates themes from Mevalonate pathway, Inflammasome, AIM2 and Cancer research.
His research integrates issues of Sterol, Protein quality, Proteostasis, Transcriptional Networks and Computational biology in his study of Protein folding.
His study in the field of ERAD pathway also crosses realms of Rhomboid.
His Ubiquitin study contributes to a more complete understanding of Biochemistry.
This overview was generated by a machine learning system which analysed the scientist’s
body of work. If you have any feedback, you can
contact us
here.
