World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
38504
World Ranking
7610
National Ranking
64

Research.com Recognitions

  • 2007 - Fellow of the American Academy of Arts and Sciences
  • 2004 - Nobel Prize for the discovery of ubiquitin-mediated protein degradation
  • 2003 - Member of the National Academy of Sciences
  • 2002 - E.B. Wilson Medal, American Society for Cell Biology
  • 2001 - Louisa Gross Horwitz Prize, Columbia University
  • 2000 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 2000 - Alfred P. Sloan Jr. Prize, General Motors Cancer Research Foundation
  • 1999 - Canada Gairdner International Award
  • Foreign Member, Chinese Academy of Sciences
  • Member of the European Molecular Biology Organization (EMBO)
  • Foreign Member, Chinese Academy of Sciences
  • Member of the European Molecular Biology Organization (EMBO)
  • Foreign Member, Chinese Academy of Sciences
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Avram Hershko is affiliated with the Technion - Israel Institute of Technology in Israel. Their research broadly spans the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Cell Biology, and Materials Chemistry as subfields. The scientist's work explores topics such as Microtubule and mitosis dynamics, Photosynthetic Processes and Mechanisms, Cellular transport and secretion, Protist diversity and phylogeny, Ubiquitin and proteasome pathways, Genomics and Chromatin Dynamics, and Enzyme Structure and Function.

Frequent publication venues include the Proceedings of the National Academy of Sciences and the International Journal of Emerging Scientific Research. Hershko has contributed to several papers, some of which are:

  • Role of phosphorylation of Cdc20 in the regulation of the action of APC/C in mitosis, 2022, Proceedings of the National Academy of Sciences
  • Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes, 2022, Proceedings of the National Academy of Sciences
  • The Mitotic Checkpoint Complex controls the association of Cdc20 regulatory protein with the ubiquitin ligase APC/C in mitosis, 2024, Proceedings of the National Academy of Sciences
  • Attempt on Magnification of the Mechanism of Enzyme Catalyzed Reaction through Bio-geometric Model for the Five Points Circle in the Triangular Form of Lineweaver-Burk Plot, 2020, International Journal of Emerging Scientific Research

Collaborations are noted with several frequent co-authors, including:

  • Shirly Miniowitz-Shemtov
  • Sharon Kaisari
  • Danielle Sitry-Shevah
  • Danielle Shevah-Sitry
  • Adar Teichner

Avram Hershko has received several awards and honors over the years. These include the Nobel Prize in 2004 for the discovery of ubiquitin-mediated protein degradation. Additional recognitions include the Fellow of the American Academy of Arts and Sciences in 2007, membership in the National Academy of Sciences in 2003, the E.B. Wilson Medal from the American Society for Cell Biology in 2002, the Louisa Gross Horwitz Prize from Columbia University in 2001, the Alfred P. Sloan Jr. Prize from the General Motors Cancer Research Foundation in 2000, the Albert Lasker Award for Basic Medical Research in 2000, and the Canada Gairdner International Award in 1999. Further distinctions include Foreign Member of the Chinese Academy of Sciences and membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • The Ubiquitin System

    Avram Hershko;Aaron Ciechanover

  • SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.

    Andrea C. Carrano;Esther Eytan;Avram Hershko;Michele Pagano

  • The ubiquitin system for protein degradation

    Avram Hershko;Aaron Ciechanover

  • Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

    A Hershko;H Heller;S Elias;A Ciechanover

  • Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

    Avram Hershko;Aaron Ciechanover;Hannah Heller;Arthur L. Haas

  • Basic Medical Research Award. The ubiquitin system.

    Avram Hershko;Aaron Ciechanover;Alexander Varshavsky

  • Mechanisms of intracellular protein breakdown

    and A Hershko;A Ciechanover

  • ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation.

    Aaron Ciechanover;Hannah Heller;Sarah Elias;Arthur L. Haas

  • Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

    Alessia Montagnoli;Francesca Fiore;Esther Eytan;Andrea C. Carrano

  • The cell-cycle regulatory protein Cks1 is required for SCF Skp2 -mediated ubiquitinylation of p27

    Dvora Ganoth;Gil Bornstein;Tun K. Ko;Brett Larsen

  • Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase.

    Gil Bornstein;Joanna Bloom;Danielle Sitry-Shevah;Keiko Nakayama

  • Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation.

    A L Haas;J V Warms;A Hershko;I A Rose

  • Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

    Luca Busino;Maddalena Donzelli;Massimo Chiesa;Daniele Guardavaccaro

  • ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

    Esther Eytan;Dvorah Ganoth;Tamar Armon;Avram Hershko

  • Roles of ubiquitin-mediated proteolysis in cell cycle control.

    Avram Hershko

  • The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle

    A Hershko

  • Studies on the Degradation of Tyrosine Aminotransferase in Hepatoma Cells in Culture: INFLUENCE OF THE COMPOSITION OF THE MEDIUM AND ADENOSINE TRIPHOSPHATE DEPENDENCE

    Avram Hershko;Gordon M. Tomkins

  • "Covalent affinity" purification of ubiquitin-activating enzyme.

    Aaron Ciechanover;Sarah Elias;Hannah Heller;Avram Hershko

  • Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates.

    Avram Hershko;Hannah Heller

  • Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes.

    A Ciechanover;S Elias;H Heller;S Ferber

Frequent Co-Authors

Aaron Ciechanover
Aaron Ciechanover Technion – Israel Institute of Technology
Michele Pagano
Michele Pagano New York University
Joan V. Ruderman
Joan V. Ruderman Harvard University
Giulio Draetta
Giulio Draetta The University of Texas MD Anderson Cancer Center
Gordon M. Tomkins
Gordon M. Tomkins University of California, San Francisco
Arthur L. Haas
Arthur L. Haas Louisiana State University Health Sciences Center New Orleans
Tim J. Yen
Tim J. Yen Fox Chase Cancer Center
Hongtao Yu
Hongtao Yu The University of Texas Southwestern Medical Center
Mike Tyers
Mike Tyers University of Montreal
Alexander Varshavsky
Alexander Varshavsky California Institute of Technology

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