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Molecular Biology

D-Index
61
Citations
15568
World Ranking
1896
National Ranking
943

Overview

Tim M. Townes is affiliated with the University of Alabama at Birmingham in the United States. Their research focuses primarily on medicine and biochemistry, genetics, and molecular biology. The scientist's work spans multiple specialized subfields, including genetics, molecular biology, cancer research, pediatrics, perinatology and child health, as well as pulmonary and respiratory medicine.

The main topics covered in their research include hemoglobinopathies and related disorders, cancer genomics and diagnostics, prenatal screening and diagnostics, epigenetics and DNA methylation, CRISPR and genetic engineering, cancer immunotherapy and biomarkers, and hidradenitis suppurativa and treatments.

Frequent coauthors collaborating with Tim M. Townes are:

  • Kevin M. Pawlik
  • Lin Luo
  • Chuan Xing
  • Li Mao
  • Ling Zeng

Tim M. Townes has published in several notable scientific venues, including:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Cancer
  • Proceedings of the National Academy of Sciences
  • PLoS ONE

Representative recent publications include:

  • RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+ T-cell-dependent antitumor immunity, 2021, Nature Cancer
  • Epigenetic switch reshapes epithelial progenitor cell signatures and drives inflammatory pathogenesis in hidradenitis suppurativa, 2023, Proceedings of the National Academy of Sciences
  • Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells, 2023, PLoS ONE
  • Validation of single-gene noninvasive prenatal testing for sickle cell disease, 2022, American Journal of Hematology
  • Engineering, Generation and Preliminary Characterization of a Humanized Porcine Sickle Cell Disease Animal Model, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin

    Jacob Hanna;Marius Wernig;Marius Wernig;Styliani Markoulaki;Styliani Markoulaki;Chiao-Wang Sun;Chiao-Wang Sun

  • ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology: Implication for Coffin-Lowry Syndrome

    Xiangli Yang;Koichi Matsuda;Peter Bialek;Sylvie Jacquot

  • Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation

    Ichiro Hiratani;Tyrone Ryba;Mari Itoh;Tomoki Yokochi

  • Erythroid-specific expression of human beta-globin genes in transgenic mice.

    T.M. Townes;J.B. Lingrel;H.Y. Chen;R.L. Brinster

  • KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.

    Dewang Zhou;Kaimao Liu;Chiao-Wang Sun;Kevin M Pawlik

  • Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease

    Mutay Aslan;Thomas M. Ryan;Brian Adler;Tim M. Townes

  • Correction of sickle cell disease by homologous recombination in embryonic stem cells.

    Li-Chen Wu;Chiao-Wang Sun;Thomas M. Ryan;Kevin M. Pawlik

  • Knockout-transgenic mouse model of sickle cell disease

    T. M. Ryan;D. J. Ciavatta;T. M. Townes

  • Human gamma- to beta-globin gene switching in transgenic mice

    Richard R. Behringer;Thomas M. Ryan;Richard D. Palmiter;Ralph L. Brinster

  • Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase

    Wen Yong Chen;Evans C. Bailey;Steven L. McCune;Jian-Yun Dong

  • Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells.

    Chia‐Wei Chang;Yi‐Shin Lai;Kevin M. Pawlik;Kaimao Liu

  • A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

    T M Ryan;R R Behringer;N C Martin;T M Townes

  • Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice

    Howard C. Masuoka;Tim M. Townes

  • Homocysteine Increases the Expression of Vascular Endothelial Growth Factor by a Mechanism Involving Endoplasmic Reticulum Stress and Transcription Factor ATF4

    C. Nathaniel Roybal;Shujie Yang;Chiao Wang Sun;Diego Hurtado

  • Role of erythroid Kruppel-like factor in human gamma- to beta-globin gene switching.

    David Donze;Tim M. Townes;James J. Bieker

  • ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

    Philipp S. Lange;Juan C. Chavez;John T. Pinto;Giovanni Coppola

  • Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.

    Margaret A. Young;David E. Larson;Chiao Wang Sun;Daniel R. George

  • Human globin locus activation region (LAR): role in temporal control.

    Tim M. Townes;Richard R. Behringer

  • Correction of a mouse model of sickle cell disease: lentiviral/antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells

    Dana N. Levasseur;Thomas M. Ryan;Kevin M. Pawlik;Tim M. Townes

  • Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia

    K Wade Foster;Zhaoli Liu;Clinton D Nail;Xingnan Li

Frequent Co-Authors

Ralph L. Brinster
Ralph L. Brinster University of Pennsylvania
Richard R. Behringer
Richard R. Behringer The University of Texas MD Anderson Cancer Center
Jerry B. Lingrel
Jerry B. Lingrel University of Cincinnati
Suzanne Oparil
Suzanne Oparil University of Alabama at Birmingham
Richard D. Palmiter
Richard D. Palmiter University of Washington
Louise T. Chow
Louise T. Chow University of Alabama at Birmingham
Josef T. Prchal
Josef T. Prchal University of Utah
J. Michael Wyss
J. Michael Wyss University of Alabama at Birmingham
Stephen Barnes
Stephen Barnes University of Alabama at Birmingham
Hediye Erdjument-Bromage
Hediye Erdjument-Bromage New York University

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