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Biology and Biochemistry

D-Index
53
Citations
19539
World Ranking
15902
National Ranking
6606

Overview

Timothy P. Heffernan is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research spans multiple disciplines, primarily focusing on biochemistry, genetics, molecular biology, and medicine. The scientist's work involves subfields such as molecular biology, oncology, cancer research, immunology, and pulmonary and respiratory medicine.

The scientist's main research topics include:

  • Cancer Genomics and Diagnostics
  • Pancreatic and Hepatic Oncology Research
  • Cancer-related Molecular Pathways
  • Cancer, Hypoxia, and Metabolism
  • Phagocytosis and Immune Regulation
  • Single-cell and spatial transcriptomics
  • Melanoma and MAPK Pathways

Timothy P. Heffernan has contributed to various publications in notable venues, with a strong presence in:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • European Journal of Cancer
  • Cancer Discovery

Some of the recent scientific papers associated with topics related to their research are as follows:

  • BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition, 2020, Cancer Discovery
  • Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials, 2023, Nature Medicine
  • Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis, 2021, Science
  • KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells, 2023, Cancer Cell
  • Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis, 2021, Cancer Discovery

Frequent co-authors collaborating with Timothy P. Heffernan include:

  • Ningping Feng
  • Joseph R. Marszalek
  • Christopher P. Vellano
  • Christopher A. Bristow
  • Giulio Draetta

Best Publications

  • BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

    Jake E. Delmore;Ghayas C. Issa;Madeleine E. Lemieux;Peter B. Rahl

  • Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

    Weiyi Peng;Jie Qing Chen;Chengwen Liu;Shruti Malu

  • Telomere dysfunction induces metabolic and mitochondrial compromise

    Ergiin Sahin;Simona Colla;Marc Liesa;Javid Moslehi

  • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

    Andrea Viale;Piergiorgio Pettazzoni;Costas A. Lyssiotis;Haoqiang Ying

  • An inhibitor of oxidative phosphorylation exploits cancer vulnerability.

    Jennifer R. Molina;Yuting Sun;Marina Protopopova;Sonal Gera

  • Melanoma genome sequencing reveals frequent PREX2 mutations

    Michael F. Berger;Michael F. Berger;Eran Hodis;Timothy P. Heffernan;Timothy P. Heffernan;Yonathan Lissanu Deribe

  • Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

    Ferdinandos Skoulidis;Lauren A. Byers;Lixia Diao;Vassiliki A. Papadimitrakopoulou

  • Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

    Avnish Kapoor;Wantong Yao;Haoqiang Ying;Sujun Hua

  • Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.

    Tina Cascone;Jodi A. McKenzie;Rina M. Mbofung;Simone Punt

  • Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

    Guocan Wang;Xin Lu;Prasenjit Dey;Pingna Deng

  • PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.

    Joanne I. Hsu;Joanne I. Hsu;Tajhal Dayaram;Ayala Tovy;Etienne De Braekeleer;Etienne De Braekeleer

  • BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

    Marco H Hofmann;Michael Gmachl;Juergen Ramharter;Fabio Savarese

  • An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

    Timothy P. Heffernan;Dennis A. Simpson;Alexandra R. Frank;Alexandra N. Heinloth

  • The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies.

    Bhavatarini Vangamudi;Thomas A Paul;Parantu K Shah;Maria Kost-Alimova

  • Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer

    Likun Li;Styliani Karanika;Guang Yang;Jiangxiang Wang

  • Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state

    Gloria V. Echeverria;Zhongqi Ge;Sahil Seth;Xiaomei Zhang

  • Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

    Liang Zhang;Yixin Yao;Shaojun Zhang;Yang Liu

  • Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development

    Ruprecht Wiedemeyer;Cameron Brennan;Cameron Brennan;Timothy P. Heffernan;Yonghong Xiao

  • Targeting YAP-dependent MDSC infiltration impairs tumor progression

    Guocan Wang;Xin Lu;Prasenjit Dey;Pingna Deng

  • Melanoma genome sequencing reveals frequent PREX2 mutations

    Eric S. Lander;Michael F. Berger;Eran Hodis;Timothy P. Heffernan

Frequent Co-Authors

Giulio Draetta
Giulio Draetta The University of Texas MD Anderson Cancer Center
Ronald A. DePinho
Ronald A. DePinho The University of Texas MD Anderson Cancer Center
Jason B. Fleming
Jason B. Fleming The University of Texas MD Anderson Cancer Center
Carlo Toniatti
Carlo Toniatti The University of Texas MD Anderson Cancer Center
Patrick Hwu
Patrick Hwu The University of Texas MD Anderson Cancer Center
Haoqiang Ying
Haoqiang Ying The University of Texas MD Anderson Cancer Center
Anirban Maitra
Anirban Maitra The University of Texas MD Anderson Cancer Center
Jianhua Zhang
Jianhua Zhang The University of Texas MD Anderson Cancer Center
Jeffrey T. Chang
Jeffrey T. Chang The University of Texas Health Science Center at Houston
Alexei Protopopov
Alexei Protopopov The University of Texas MD Anderson Cancer Center

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