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Biology and Biochemistry

D-Index
56
Citations
11875
World Ranking
14382
National Ranking
6058

Overview

William K. Kaufmann is affiliated with AsystBio in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant work in medicine. They have contributed notably to the fields of molecular biology, oncology, plant science, cancer research, and pathology and forensic medicine.

The main topics covered in Kaufmann's research include DNA repair mechanisms, cancer-related molecular pathways, cutaneous melanoma detection and management, cancer genomics and diagnostics, DNA and nucleic acid chemistry, mitochondrial function and pathology, and cancer therapeutics and mechanisms.

Kaufmann has a record of publications in the UNC Libraries, which is also the most frequent venue for their work, totaling 36 publications. Some of their recent papers include:

  • Profiles of Global Gene Expression in Ionizing-Radiation-Damaged Human Diploid Fibroblasts Reveal Synchronization behind the G1 Checkpoint in a G0-like State of Quiescence, 2020, UNC Libraries
  • Identification of Primary Transcriptional Regulation of Cell Cycle-Regulated Genes upon DNA Damage, 2020, UNC Libraries
  • Quantitative relationship between hepatocytic neoplasms and islands of cellular alteration during hepatocarcinogenesis in the male F344 rat., 2020, UNC Libraries
  • Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage, 2020, UNC Libraries
  • DNA Damage Checkpoint Responses in the S Phase of Synchronized Diploid Human Fibroblasts, 2020, UNC Libraries

Kaufmann collaborates frequently with a group of coauthors. These collaborators include Dennis A. Simpson, Marila Cordeiro-Stone, Joseph G. Ibrahim, Yingchun Zhou, and Richard S. Paules, with whom Kaufmann has co-authored multiple publications, demonstrating ongoing research partnerships in related fields.

Best Publications

  • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

    Vjekoslav Dulić;William K. Kaufmann;William K. Kaufmann;Sandra J. Wilson;Sandra J. Wilson;Thea D. Tisty;Thea D. Tisty

  • Oxidative stress and cell cycle checkpoint function

    Rodney E. Shackelford;William K. Kaufmann;Richard S. Paules

  • Standardizing global gene expression analysis between laboratories and across platforms

    Theodore Bammler;Richard P. Beyer;Sanchita Bhattacharya;Gary A. Boorman

  • DNA damage and cell cycle checkpoints.

    William K. Kaufmann;Richard S. Paules

  • Cell cycle control, checkpoint mechanisms, and genotoxic stress.

    Rodney E. Shackelford;William K. Kaufmann;Richard S. Paules

  • Coupling of human circadian and cell cycles by the timeless protein

    Keziban Ünsal-Kaçmaz;Thomas E. Mullen;William K. Kaufmann;Aziz Sancar

  • An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

    Timothy P. Heffernan;Dennis A. Simpson;Alexandra R. Frank;Alexandra N. Heinloth

  • The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.

    Keziban Ünsal-Kaçmaz;Paul D. Chastain;Ping Ping Qu;Parviz Minoo

  • Enhanced Replicative Bypass of Platinum-DNA Adducts in Cisplatin-resistant Human Ovarian Carcinoma Cell Lines

    Edward L. Mamenta;Eric E. Poma;William K. Kaufmann;Dean A. Delmastro

  • The human decatenation checkpoint.

    Paula B. Deming;Cheryl A. Cistulli;Hui Zhao;Paul R. Graves

  • Control of skin cancer by the circadian rhythm

    Shobhan Gaddameedhi;Christopher P. Selby;William K. Kaufmann;Robert C. Smart

  • Cell-Type-Specific Responses to Chemotherapeutics in Breast Cancer

    Melissa A. Troester;Katherine A. Hoadley;Therese Sørlie;Brittney Shea Herbert

  • Defective G2 Checkpoint Function in Cells from Individuals with Familial Cancer Syndromes

    Richard S. Paules;Eleni N. Levedakou;Sandra J. Wilson;Cynthia L. Innes

  • Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesis

    Marila Cordeiro-Stone;Liubov S. Zaritskaya;Laura K. Price;William K. Kaufmann

  • Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress

    Michael G. Kemp;Zafer Akan;Seçil Yilmaz;Mary Grillo

  • Liver regeneration and hepatocarcinogenesis in transforming growth factor‐α‐targeted mice

    William E. Russell;William K. Kaufmann;Silvio Sitaric;Noreen C. Luetteke

  • Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032

    Maria J. Sambade;Eldon C. Peters;Nancy E. Thomas;William K. Kaufmann

  • DNA-dependent Protein Kinase Is Not Required for Accumulation of p53 or Cell Cycle Arrest after DNA Damage

    W K Rathmell;W K Kaufmann;J C Hurt;L L Byrd

  • Chromosomal instability is correlated with telomere erosion and inactivation of G2 checkpoint function in human fibroblasts expressing human papillomavirus type 16 E6 oncoprotein

    Leonid Filatov;Vita Golubovskaya;John C Hurt;Laura L Byrd

  • Caffeine and human DNA metabolism: the magic and the mystery

    William K. Kaufmann;Timothy P. Heffernan;Lea M. Beaulieu;Sharon Doherty

Frequent Co-Authors

Richard S. Paules
Richard S. Paules National Institutes of Health
Joseph G. Ibrahim
Joseph G. Ibrahim University of North Carolina at Chapel Hill
Pierre R. Bushel
Pierre R. Bushel National Institutes of Health
Aziz Sancar
Aziz Sancar University of North Carolina at Chapel Hill
Terrance J. Kavanagh
Terrance J. Kavanagh University of Washington
Charles M. Perou
Charles M. Perou University of North Carolina at Chapel Hill
David L. Mitchell
David L. Mitchell The University of Texas MD Anderson Cancer Center
Ivan Rusyn
Ivan Rusyn Texas A&M University
Shannon C. Kenney
Shannon C. Kenney University of Wisconsin–Madison

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