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D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
18866
World Ranking
9024
National Ranking
4011

Overview

Richard S. Paules is affiliated with the National Institutes of Health in the United States and works primarily in the fields of biochemistry, genetics, and molecular biology. Their research encompasses various subfields including molecular biology, cancer research, computational theory and mathematics, environmental chemistry, and physiology.

The scientist's work spans multiple topics centered around DNA repair mechanisms, computational drug discovery methods, carcinogens and genotoxicity assessment, molecular biology techniques and applications, metabolomics and mass spectrometry studies, animal testing and alternatives, and chemistry and chemical engineering.

Richard S. Paules has contributed to numerous research papers published in a range of scientific venues. Selected recent publications include:

  • The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology (2020, Chemical Research in Toxicology)
  • Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes (2020, Toxicological Sciences)
  • Comparison of Normalization Methods for Analysis of TempO-Seq Targeted RNA Sequencing Data (2020, Frontiers in Genetics)
  • Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors (2024, Environmental Health Perspectives)
  • KRAS-retroviral fusion transcripts and gene amplification in arsenic-transformed, human prostate CAsE-PE cancer cells (2020, Toxicology and Applied Pharmacology)

Their frequent co-authors include William K. Kaufmann, Dennis A. Simpson, Scott S. Auerbach, Ruchir Shah, and Dhiral Phadke. Collaboration with these researchers points to interdisciplinary work across molecular biology and toxicological sciences.

Richard S. Paules's publications appear in venues such as UNC Libraries, Chemical Research in Toxicology, Toxicological Sciences, Frontiers in Genetics, and Environmental Health Perspectives, reflecting a wide dissemination of their research findings.

Best Publications

  • An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

    Heather P. Harding;Yuhong Zhang;Huiquing Zeng;Isabel Novoa

  • Assessing Gene Significance from cDNA Microarray Expression Data via Mixed Models

    Russell D. Wolfinger;Greg Gibson;Elizabeth D. Wolfinger;Lee Bennett

  • The Microarray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

    Leming Shi;Gregory Campbell;Wendell D. Jones;Fabien Campagne

  • Oxidative stress and cell cycle checkpoint function

    Rodney E. Shackelford;William K. Kaufmann;Richard S. Paules

  • Standardizing global gene expression analysis between laboratories and across platforms

    Theodore Bammler;Richard P. Beyer;Sanchita Bhattacharya;Gary A. Boorman

  • The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance

    Charles Wang;Binsheng Gong;Pierre R. Bushel;Jean Thierry-Mieg

  • Gene expression analysis reveals chemical-specific profiles.

    Hisham K. Hamadeh;Pierre R. Bushel;Supriya Jayadev;Karla Martin

  • DNA damage and cell cycle checkpoints.

    William K. Kaufmann;Richard S. Paules

  • Cell cycle control, checkpoint mechanisms, and genotoxic stress.

    Rodney E. Shackelford;William K. Kaufmann;Richard S. Paules

  • Prediction of compound signature using high density gene expression profiling

    Hisham K. Hamadeh;Pierre R. Bushel;Supriya Jayadev;Olimpia DiSorbo

  • An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

    Timothy P. Heffernan;Dennis A. Simpson;Alexandra R. Frank;Alexandra N. Heinloth

  • Gene expression profiling of rat livers reveals indicators of potential adverse effects.

    Alexandra N. Heinloth;Richard D. Irwin;Gary A. Boorman;Paul Nettesheim

  • The human decatenation checkpoint.

    Paula B. Deming;Cheryl A. Cistulli;Hui Zhao;Paul R. Graves

  • Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

    Dragony Fu;Jennifer A. N. Brophy;Clement T. Y. Chan;Kyle A. Atmore

  • Mouse Mos protooncogene product is present and functions during oogenesis.

    R S Paules;R Buccione;R C Moschel;G F Vande Woude

  • Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base.

    Michael Waters;Gary Boorman;Pierre Bushel;Michael Cunningham

  • Defective G2 Checkpoint Function in Cells from Individuals with Familial Cancer Syndromes

    Richard S. Paules;Eleni N. Levedakou;Sandra J. Wilson;Cynthia L. Innes

  • The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology.

    Ann M Richard;Ruili Huang;Suramya Waidyanatha;Paul Shinn

  • An overview of toxicogenomics.

    Hisham K. Hamadeh;Rupesh P. Amin;Richard S. Paules;Cynthia A. Afshari

  • Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

    Dragony Fu;Jennifer Ann Brophy;Tsz Yan Clement Chan;Kyle Aaquil Atmore

Frequent Co-Authors

Pierre R. Bushel
Pierre R. Bushel National Institutes of Health
William K. Kaufmann
William K. Kaufmann AsystBio (United States)
Cynthia A. Afshari
Cynthia A. Afshari Janssen (United States)
Raymond W. Tennant
Raymond W. Tennant National Institutes of Health
Weida Tong
Weida Tong National Center for Toxicological Research
Hong Fang
Hong Fang National Center for Toxicological Research
Leming Shi
Leming Shi Fudan University
Yuri Nikolsky
Yuri Nikolsky F1 Genomics
Raymond R. Tice
Raymond R. Tice National Institutes of Health
Anton Simeonov
Anton Simeonov National Institutes of Health

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