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Medicine

D-Index
91
Citations
25649
World Ranking
11894
National Ranking
377

Overview

John O. Miners is affiliated with Flinders University in Australia. Their research primarily spans the fields of Medicine, Pharmacology, Toxicology and Pharmaceutics, and Biochemistry, Genetics and Molecular Biology. Within these areas, their subfields of study include Pharmacology, Oncology, Molecular Biology, Pulmonary and Respiratory Medicine, and Pediatrics, Perinatology and Child Health.

The scientist's work focuses on topics such as Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Neonatal Health and Biochemistry, Neurotransmitter Receptor Influence on Behavior, Drug-Induced Hepatotoxicity and Protection, Cancer Immunotherapy and Biomarkers, and Colorectal Cancer Treatments and Studies.

Among recent publications are these:

  • Binding of clozapine to the GABAB receptor: clinical and structural insights, 2020, Molecular Psychiatry
  • Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease, 2022, JAMA
  • Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping, 2020, Pharmacology & Therapeutics
  • Multiorgan Immune-Related Adverse Events During Treatment With Atezolizumab, 2020, Journal of the National Comprehensive Cancer Network
  • Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance, 2023, Pharmacology & Therapeutics

The most frequent co-authors in their body of work include Andrew Rowland, Pramod C. Nair, Ashley M. Hopkins, Michael J. Sorich, and Ross A. McKinnon.

John O. Miners has published repeatedly in several key venues such as Molecular Psychiatry, Pharmacology & Therapeutics, Journal of the National Comprehensive Cancer Network, Drug Metabolism and Pharmacokinetics, and Clinical Pharmacology & Therapeutics.

Best Publications

  • Cytochrome P4502C9: an enzyme of major importance in human drug metabolism.

    John O. Miners;Donald J. Birkett

  • Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.

    Peter I Mackenzie;Karl Walter Bock;Brian Burchell;Chantal Guillemette

  • The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.

    Theresa H. Sullivan-Klose;Burhan I. Ghanayem;Douglas A. Bell;Zhi Yi Zhang

  • The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification.

    Andrew Rowland;John Oliver Miners;Peter Ian Mackenzie

  • HUMAN UDP-GLUCURONOSYLTRANSFERASES: ISOFORM SELECTIVITY AND KINETICS OF 4-METHYLUMBELLIFERONE AND 1-NAPHTHOL GLUCURONIDATION, EFFECTS OF ORGANIC SOLVENTS, AND INHIBITION BY DICLOFENAC AND PROBENECID

    Verawan Uchaipichat;Peter I. Mackenzie;Xiao-Hui Guo;Xiao-Hui Guo;Dione Gardner-Stephen

  • Drug glucuronidation in humans.

    John O. Miners;Peter I. Mackenzie

  • Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.

    W Tassaneeyakul;D J Birkett;M E Veronese;M E McManus

  • SELECTIVITY OF SUBSTRATE (TRIFLUOPERAZINE) AND INHIBITOR (AMITRIPTYLINE, ANDROSTERONE, CANRENOIC ACID, HECOGENIN, PHENYLBUTAZONE, QUINIDINE, QUININE, AND SULFINPYRAZONE) “PROBES” FOR HUMAN UDP-GLUCURONOSYLTRANSFERASES

    Verawan Nu Uchaipichat;Peter Ian Mackenzie;David John Elliot;John Oliver Miners

  • The effects of buthionine sulphoximine (BSO) on glutathione depletion and xenobiotic biotransformation

    Roger Drew;John O. Miners

  • The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potential.

    John Oliver Miners;Peter Ian Mackenzie;Kathleen Mary Knights

  • Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance.

    C. Bhasker;Wendy McKinnon;Andrew Stone;Angus Lo;Angus Lo

  • Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

    Michael H. Court;Su X. Duan;Lisa L. von Moltke;David J. Greenblatt

  • Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

    Tommy Andersson;Tommy Andersson;John O. Miners;Maurice E. Veronese;Wichittra Tassaneeyakul

  • Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.

    Chunjing Jin;J. O. Miners;K. J. Lillywhite;P. I. Mackenzie

  • Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance

    John O Miners;Ross A McKinnon;Peter I Mackenzie

  • In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.

    John Oliver Miners;Kathleen Mary Knights;J Brian Houston;Peter Ian Mackenzie

  • Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9.

    Maurice E. Veronese;Peter I. Mackenzie;Christopher J. Doecke;Michael E. McManus

  • Diazepam metabolism by human liver microsomes is mediated by both S‐ mephenytoin hydroxylase and CYP3A isoforms.

    T Andersson;JO Miners;ME Veronese;DJ Birkett

  • Caffeine metabolism by human hepatic cytochromes p450: Contributions of 1A2, 2E1 and 3A isoforms

    Wichittra Tassaneeyakul;Donald J. Birkett;Michael E. McManus;Wongwiwat Tassaneeyakul

  • In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction

    Andrew Rowland;David John Elliot;Andrew Williams;Peter Ian Mackenzie

Frequent Co-Authors

Peter I. Mackenzie
Peter I. Mackenzie Flinders University
Paul A. Smith
Paul A. Smith Australian Wine Research Institute
Joseph G. Shapter
Joseph G. Shapter University of Queensland
Richard O. Day
Richard O. Day University of New South Wales
Andrew A. Somogyi
Andrew A. Somogyi University of Adelaide
J. Brian Houston
J. Brian Houston University of Manchester
Robert H. Tukey
Robert H. Tukey University of California, San Diego
Peter Brooks
Peter Brooks University of Melbourne
David A. Winkler
David A. Winkler La Trobe University
Nicolas H. Voelcker
Nicolas H. Voelcker Monash University

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