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Medicine

D-Index
115
Citations
48241
World Ranking
4554
National Ranking
2474

Overview

John H. Healey is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their primary research area falls within the broad field of Medicine, with specific focus on subfields such as Pulmonary and Respiratory Medicine, Surgery, Rheumatology, Molecular Biology, and Oncology. The scientist has contributed notably to the subject of sarcoma and related cancers, particularly in diagnosis and treatment.

Healey's work covers several main topics, including sarcoma diagnosis and treatment, musculoskeletal synovial abnormalities and treatments, bone tumor diagnosis and treatments, management of metastatic bone disease, cancer genomics and diagnostics, orthopaedic implants and arthroplasty, and tendon structure and treatment.

The scientist has published frequently in several venues. These include Clinical Orthopaedics and Related Research, Journal of Bone and Joint Surgery, Genes Chromosomes and Cancer, bioRxiv (Cold Spring Harbor Laboratory), and The Oncologist. These outlets reflect the clinical and translational nature of the research output.

Notable recent papers authored or co-authored by Healey include:

  • Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers, 2020, Cell
  • Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition, 2020, Cancer Discovery
  • CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment, 2021, Molecular Cancer Therapeutics
  • Tumour extracellular vesicles and particles induce liver metabolic dysfunction, 2023, Nature
  • Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets, 2022, Nature Communications

Frequent co-authors working with Healey include William D. Tap, Vinagolu K. Rajasekhar, Tomohiro Fujiwara, Michiel A. J. van de Sande, and Meera Hameed. These collaborations suggest a multidisciplinary approach linking clinical, molecular, and therapeutic perspectives in cancer research.

Best Publications

  • Tumour exosome integrins determine organotropic metastasis

    Ayuko Hoshino;Bruno Costa-Silva;Tang-Long Shen;Goncalo Rodrigues

  • Chromosomal instability drives metastasis through a cytosolic DNA response.

    Samuel F. Bakhoum;Samuel F. Bakhoum;Bryan Ngo;Ashley M. Laughney;Julie Ann Cavallo;Julie Ann Cavallo

  • Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

    Ayuko Hoshino;Ayuko Hoshino;Han Sang Kim;Han Sang Kim;Linda Bojmar;Linda Bojmar;Linda Bojmar;Kofi Ennu Gyan

  • Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience.

    P A Meyers;G Heller;J Healey;A Huvos

  • Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group

    Paul A. Meyers;Cindy L. Schwartz;Mark D. Krailo;John H. Healey

  • Osteosarcoma: A Randomized, Prospective Trial of the Addition of Ifosfamide and/or Muramyl Tripeptide to Cisplatin, Doxorubicin, and High-Dose Methotrexate

    Paul A. Meyers;Cindy L. Schwartz;Mark Krailo;Eugenie S. Kleinerman

  • SYT–SSX Gene Fusion as a Determinant of Morphology and Prognosis in Synovial Sarcoma

    Akira Kawai;James Woodruff;John H. Healey;Murray F. Brennan

  • Randomized Controlled Trial of Interval-Compressed Chemotherapy for the Treatment of Localized Ewing Sarcoma: A Report From the Children's Oncology Group

    Richard B. Womer;Daniel C. West;Mark D. Krailo;Paul S. Dickman

  • Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers

    M J Scanlan;B K Raj;B Calvo;P Garin-Chesa

  • The der(17)t(x;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25

    Marc Ladanyi;Man Yee Lui;Cristina R Antonescu;Amber Krause-Boehm

  • Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients.

    Marc Ladanyi;Cristina R Antonescu;Denis H Leung;James M Woodruff

  • EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.

    E. De Alava;A. Kawai;J. H. Healey;I. Fligman

  • Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

    William D Tap;Zev A Wainberg;Stephen P Anthony;Prabha N Ibrahim

  • Discovery of a periosteal stem cell mediating intramembranous bone formation

    Shawon Debnath;Alisha R. Yallowitz;Jason McCormick;Sarfaraz Lalani

  • A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites.

    Costantino Errani;Lei Zhang;Yun Shao Sung;Mihai Hajdu

  • MDM2 Gene Amplification in Metastatic Osteosarcoma

    Marc Ladanyi;Charles Cha;Ronald Lewis;Suresh C. Jhanwar

  • Osteogenic sarcoma with clinically detectable metastasis at initial presentation.

    P. A. Meyers;G. Heller;J. H. Healey;A. Huvos

  • Dickkopf 3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-β-Catenin Pathway

    Bang H. Hoang;Tadahiko Kubo;John H. Healey;Rui Yang

  • Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol.

    Paul A. Meyers;Richard Gorlick;Glenn Heller;Ephraim Casper

  • Dose-intensified compared with standard chemotherapy for nonmetastatic ewing sarcoma family of tumors: A children's oncology group study

    Linda Granowetter;Richard Womer;Meenakshi Devidas;Mark Krailo

Frequent Co-Authors

Paul A. Meyers
Paul A. Meyers Memorial Sloan Kettering Cancer Center
Andrew G. Huvos
Andrew G. Huvos Memorial Sloan Kettering Cancer Center
Richard Gorlick
Richard Gorlick The University of Texas MD Anderson Cancer Center
Joseph M. Lane
Joseph M. Lane Hospital for Special Surgery
Cristina R. Antonescu
Cristina R. Antonescu Memorial Sloan Kettering Cancer Center
Marc Ladanyi
Marc Ladanyi Memorial Sloan Kettering Cancer Center
Murray F. Brennan
Murray F. Brennan Memorial Sloan Kettering Cancer Center
Mark Krailo
Mark Krailo University of Southern California
Jay S. Wunder
Jay S. Wunder University of Toronto
Mark C. Gebhardt
Mark C. Gebhardt Harvard Medical School

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