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Chemistry

D-Index
54
Citations
7691
World Ranking
12860
National Ranking
75

Overview

Moshe Finel is affiliated with the University of Helsinki in Finland. Their research spans multiple areas within medicine and biochemistry, particularly focusing on pharmacogenetics and drug metabolism.

The main fields of study for Moshe Finel include:

  • Medicine
  • Pharmacology, Toxicology and Pharmaceutics
  • Biochemistry, Genetics and Molecular Biology

Within these fields, subfields of study addressed are:

  • Pharmacology
  • Molecular Biology
  • Pediatrics, Perinatology and Child Health
  • Oncology
  • Endocrinology, Diabetes and Metabolism

Key topics covered in their work are:

  • Pharmacogenetics and Drug Metabolism
  • Neonatal Health and Biochemistry
  • Drug Transport and Resistance Mechanisms
  • HIV/AIDS drug development and treatment
  • Biochemical and Molecular Research
  • Metabolism and Genetic Disorders
  • Cannabis and Cannabinoid Research

The scientist has contributed to articles published in the following venues:

  • Journal of Ethnopharmacology
  • Acta Pharmaceutica Sinica B
  • Frontiers in Pharmacology
  • Drug Metabolism and Disposition
  • Nature Communications

Some of the recent papers authored or co-authored by Moshe Finel include:

  • Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives, 2022, Acta Pharmaceutica Sinica B
  • Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ, 2021, Frontiers in Pharmacology
  • A broad-spectrum substrate for the human UDP-glucuronosyltransferases and its use for investigating glucuronidation inhibitors, 2021, International Journal of Biological Macromolecules
  • A fluorescence-based microplate assay for high-throughput screening and evaluation of human UGT inhibitors, 2021, Analytica Chimica Acta
  • An ultra-sensitive and easy-to-use assay for sensing human UGT1A1 activities in biological systems, 2020, Journal of Pharmaceutical Analysis

Frequent collaborators include:

  • Guang-Bo Ge
  • Dong-Zhu Tu
  • Ya-Di Zhu
  • Qihang Zhou
  • Qiang Jin

Best Publications

  • Assembly of Respiratory Complexes I, III, and IV into NADH Oxidase Supercomplex Stabilizes Complex I in Paracoccus denitrificans

    Anke Stroh;Oliver Anderka;Kathy Pfeiffer;Takao Yagi

  • Cytochrome o (bo) is a proton pump in Paracoccus denitrificans and Escherichia coli

    Anne Puustinen;Moshe Finel;Marika Virkki;Mårten Wikström

  • Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I).

    A Majander;M Finel;M Wikström

  • Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than the other UGTs and was purified as an active dimeric enzyme

    Mika Kurkela;J. Arturo Garcı́a-Horsman;Leena Luukkanen;Saila Mörsky

  • Resolution of NADH:ubiquinone oxidoreductase from bovine heart mitochondria into two subcomplexes, one of which contains the redox centers of the enzyme.

    M Finel;J M Skehel;S P J Albracht;I M Fearnley

  • Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids.

    Anna Mazur;Cheryl F. Lichti;Paul L. Prather;Agnieszka K. Zielinska

  • The Configuration of the 17-Hydroxy Group Variably Influences the Glucuronidation of β-Estradiol and Epiestradiol by Human UDP-Glucuronosyltransferases

    Katrina Itaaho;Peter Ian Mackenzie;Shin-ichi Ikushiro;John Oliver Miners

  • Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.

    Sanna Kaivosaari;Päivi Toivonen;Leah M. Hesse;Mikko Koskinen

  • MECHANISM OF PROTON TRANSLOCATION BY THE RESPIRATORY OXIDASES : THE HISTIDINE CYCLE

    Mårten Wikström;Alexander Bogachev;Moshe Finel;Joel E. Morgan

  • Characteristics of the aerobic respiratory chains of the microaerophiles Campylobacter jejuni and Helicobacter pylori.

    Mark A. Smith;Moshe Finel;Victoria Korolik;George L. Mendz

  • UDP-Glucuronosyltransferases (UGTs) 2B7 and UGT2B17 Display Converse Specificity in Testosterone and Epitestosterone Glucuronidation, whereas UGT2A1 Conjugates Both Androgens Similarly

    Taina Sten;Ingo Bichlmaier;Tiia Kuuranne;Antti Leinonen

  • Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases

    Leena Luukkanen;Jyrki Taskinen;Mika Kurkela;Risto Kostiainen

  • Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases

    Tiia Kuuranne;Mika Kurkela;Mario Thevis;Wilhelm Schänzer

  • Structural and functional analysis of aa3-type and cbb3-type cytochrome c oxidases of Paracoccus denitrificans reveals significant differences in proton-pump design.

    Jan-Willem L. de Gier;Mike Schepper;Willem N.M. Reijnders;Stef J. van Dyck

  • Deletion of the gene for subunit III leads to defective assembly of bacterial cytochrome oxidase.

    T. Haltia;M. Finel;N. Harms;T. Nakari

  • Catalytic Activity of Complex I in Cell Lines that Possess Replacement Mutations in the ND Genes in Leber's Hereditary Optic Neuropathy

    Anna Majander;Moshe Finel;Marja-Liisa Savontaus;Eeva Nikoskelainen

  • Studies on the role of the oligomeric state and subunit III of cytochrome oxidase in proton translocation

    Moshe Finel;Mårten Wikström

  • Influence of metabolism on endocrine activities of bisphenol S

    Unknown

  • Organization and evolution of structural elements within complex I.

    Moshe Finel

  • Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.

    Mika Kurkela;Anne-Sisko Patana;Peter I. Mackenzie;Michael H. Court

  • Isolation and Characterisation of Subcomplexes of the Mitochondrial NADH: Ubiquinone Oxidoreductase (Complex I)

    Moshe Finel;Anna S. Majander;Jaana Tyynelä;A. Mariette P. De Jong

  • The Paracoccus denitrificans cytochrome aa3 has a third subunit

    Tuomas Haltia;Anne Puustinen;Moshe Finel

Frequent Co-Authors

Risto Kostiainen
Risto Kostiainen University of Helsinki
Jouni Hirvonen
Jouni Hirvonen University of Helsinki
Mårten Wikström
Mårten Wikström University of Helsinki
Ilmo E. Hassinen
Ilmo E. Hassinen University of Oulu
Peter I. Mackenzie
Peter I. Mackenzie Flinders University
Hongbo Zhang
Hongbo Zhang Åbo Akademi University
Matti Saraste
Matti Saraste European Bioinformatics Institute
Heinrich Lang
Heinrich Lang Chemnitz University of Technology
Raimo A. Ketola
Raimo A. Ketola Finnish Institute for Health and Welfare (THL)
Dicky J. J. Halley
Dicky J. J. Halley Erasmus University Rotterdam

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