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Biology and Biochemistry

D-Index
55
Citations
14771
World Ranking
14836
National Ranking
1171

Overview

Humphrey Gardner is affiliated with AstraZeneca in the United Kingdom and has contributed extensively to the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Their research mainly intersects oncology, immunology, and molecular biology, with additional interests in biotechnology and epidemiology.

Their recent scholarly output covers a range of topics including cancer immunotherapy and biomarkers, interferon and immune responses, immune response and inflammation, cancer research and treatments, cytokine signaling pathways and interactions, antibiotic resistance in bacteria, and bacterial identification and susceptibility testing.

Humphrey Gardner has been involved in multiple research publications, including the following papers:

  • Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence, 2022, published in bioRxiv (Cold Spring Harbor Laboratory)
  • Development of a novel loop-mediated isothermal amplification assay for ß-lactamase gene identification using clinical isolates of Gram-negative bacteria, 2023, published in Frontiers in Cellular and Infection Microbiology
  • 495 Trial of SNX281, a systemically delivered small molecule STING agonist, in solid tumors and lymphomas, 2021, published in Regular and Young Investigator Award Abstracts
  • Abstract PS11-27: A phase I/II clinical trial of EDP1503 with pembrolizumab for triple-negative breast cancer, 2021, published in Cancer Research
  • Primary cilia are critical for tracheoesophageal septation, 2023, published in Developmental Dynamics

Their frequent publication venues include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Cellular and Infection Microbiology
  • Regular and Young Investigator Award Abstracts
  • Developmental Dynamics

Throughout their collaborative work, Humphrey Gardner has co-authored studies with several researchers, including:

  • Meghana Kulkarni
  • Péter Sandy
  • Cheryl M. Koh
  • Evan L. Chiswick
  • Christopher Winter

Best Publications

  • Cyclin D1 provides a link between development and oncogenesis in the retina and breast

    Piotr Sicinski;Joana Liu Donaher;Susan B. Parker;Susan B. Parker;Tiansen Li

  • Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

    Piotr Sicinski;Joana Liu Donaher;Yan Geng;Susan B. Parker

  • Cyclin E ablation in the mouse.

    Yan Geng;Qunyan Yu;Ewa Sicinska;Ewa Sicinska;Manjusri Das

  • Phase II Randomized Study of Neoadjuvant Everolimus Plus Letrozole Compared With Placebo Plus Letrozole in Patients With Estrogen Receptor–Positive Breast Cancer

    José Baselga;Vladimir Semiglazov;Peter van Dam;Alexey Manikhas

  • Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization

    Ambra Pozzi;Philip E. Moberg;Lindsey A. Miles;Simone Wagner

  • Requirement for CDK4 kinase function in breast cancer

    Qunyan Yu;Ewa Sicinska;Yan Geng;Marie Ahnström

  • Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.

    A. Vassalli;M. M. Matzuk;H. A. R. Gardner;Kuo-Fen Lee

  • Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion.

    Humphrey Gardner;Jordan Kreidberg;Victor Koteliansky;Rudolf Jaenisch

  • Integrin α1β1 Mediates a Unique Collagen-dependent Proliferation Pathway In Vivo

    Ambra Pozzi;Kishore K. Wary;Filippo G. Giancotti;Humphrey A. Gardner

  • Development of mice expressing a single D-type cyclin

    Maria A. Ciemerych;Anna M. Kenney;Ewa Sicinska;Ilona Kalaszczynska

  • Profiles of matrix metalloproteinases, their inhibitors, and laminin in stroke patients: influence of different therapies.

    Solveig Horstmann;Pamela Kalb;James Koziol;Humphrey Gardner

  • Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.

    Curdin Conrad;Onur Boyman;Onur Boyman;Giulia Tonel;Giulia Tonel;Adrian Tun-Kyi

  • The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility

    Veronica N. Kos;Maxime Déraspe;Robert E. McLaughlin;James D. Whiteaker

  • Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis

    Antonin R. de Fougerolles;Andrew G. Sprague;Cheryl L. Nickerson-Nutter;Gloria Chi-Rosso

  • Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis.

    Humphrey Gardner;Arsi Broberg;Ambra Pozzi;Mattie Laato

  • αvβ6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse

    Kyungmin Hahm;Matvey E. Lukashev;Yi Luo;William J. Yang

  • PIK3CA Mutations May Be Discordant between Primary and Corresponding Metastatic Disease in Breast Cancer

    Jeanette Dupont Jensen;Anne Vibeke Laenkholm;Ann Knoop;Ann Knoop;Marianne Ewertz;Marianne Ewertz

  • Integrin α1β1 and Transforming Growth Factor-β1 Play Distinct Roles in Alport Glomerular Pathogenesis and Serve as Dual Targets for Metabolic Therapy

    Dominic E Cosgrove;Kathryn Rodgers;Daniel Meehan;Caroline Miller

  • Treatment of murine lupus with cDNA encoding IFN-γR/Fc

    Brian R. Lawson;Gerald J. Prud’homme;Yigang Chang;Humphrey A. Gardner

  • Zfx mutation results in small animal size and reduced germ cell number in male and female mice.

    Shiuh Wen Luoh;Paul A. Bain;Roberto D. Polakiewicz;Mary L. Goodheart

Frequent Co-Authors

James A. Koziol
James A. Koziol Scripps Research Institute
José Baselga
José Baselga Memorial Sloan Kettering Cancer Center
Raghu Kalluri
Raghu Kalluri The University of Texas MD Anderson Cancer Center
Onur Boyman
Onur Boyman University of Zurich
Frank O. Nestle
Frank O. Nestle Deerfield (United States)
Ambra Pozzi
Ambra Pozzi Vanderbilt University Medical Center
Roderick T. Bronson
Roderick T. Bronson Harvard University
Antonin de Fougerolles
Antonin de Fougerolles Alnylam Pharmaceuticals (United States)
Sabine Heiland
Sabine Heiland University Hospital Heidelberg
Paul H. Weinreb
Paul H. Weinreb Biogen (United States)

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