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Immunology

D-Index
93
Citations
44747
World Ranking
947
National Ranking
520

Medicine

D-Index
93
Citations
44985
World Ranking
10681
National Ranking
5492

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Frank O. Nestle is affiliated with King's College London in the United Kingdom. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with notable engagement across subfields including Immunology, Dermatology, Molecular Biology, Rheumatology, and Pathology and Forensic Medicine.

Recent publications by Nestle include the following:

  • Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function, 2022, Nature Genetics
  • CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway, 2020, Journal of Investigative Dermatology
  • Current and Emerging Strategies to Inhibit Type 2 Inflammation in Atopic Dermatitis, 2022, Dermatology and Therapy
  • Additive efficacy of a bispecific anti-TNF/IL-6 nanobody compound in translational models of rheumatoid arthritis, 2023, Science Translational Medicine
  • Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis, 2021, Nature Communications

Frequent co-authors collaborating with Nestle include:

  • Emanuele de Rinaldis
  • Virginia Savova
  • Paola Di Meglio
  • Richa Hanamsagar
  • Mathew Chamberlain

Frequently chosen publication venues for their work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Respiratory and Critical Care Medicine
  • Nature Communications
  • Research Square (Research Square)
  • Journal of Investigative Dermatology

Main research topics addressed by Nestle include:

  • Dermatology and Skin Diseases
  • T-cell and B-cell Immunology
  • Systemic Lupus Erythematosus Research
  • Psoriasis: Treatment and Pathogenesis
  • Single-cell and spatial transcriptomics
  • Immune Cell Function and Interaction
  • Systemic Sclerosis and Related Diseases

Among the honors awarded, Nestle is recognized as a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells.

    Frank O. Nestle;Selma Alijagic;Michel Gilliet;Yuansheng Sun

  • Mechanisms of Disease: Psoriasis.

    Frank O. Nestle;Daniel H. Kaplan;Jonathan Barker

  • Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.

    Roberto Lande;Josh Gregorio;Valeria Facchinetti;Bithi Chatterjee;Bithi Chatterjee

  • Skin immune sentinels in health and disease

    Frank O. Nestle;Paola Di Meglio;Jian-Zhong Qin;Brian J. Nickoloff

  • Plasmacytoid predendritic cells initiate psoriasis through interferon-α production

    Frank O. Nestle;Curdin Conrad;Adrian Tun-Kyi;Bernhard Homey

  • The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

    Antonella Di Cesare;Paola Di Meglio;Frank O. Nestle

  • Infliximab induction and maintenance therapy for moderate-to-severe psoriasis : a phase III, multicentre, double-blind trial

    Kristian Reich;Frank O Nestle;Kim Papp;Jean-Paul Ortonne

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    Lam C. Tsoi;Sarah L. Spain;Sarah L. Spain;Jo Knight;Eva Ellinghaus;Eva Ellinghaus

  • A Genome-Wide Association Study Identifies New Psoriasis Susceptibility Loci and an Interaction Between HLA-C and ERAP1

    Amy Strange;Francesca Capon;Chris C A Spencer

  • Mechanisms regulating skin immunity and inflammation

    Manolis Pasparakis;Ingo Haase;Frank O. Nestle

  • Mapping cis - and trans -regulatory effects across multiple tissues in twins

    E Grundberg;K S Small;K S Small;Å K Hedman;A C Nica

  • Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions

    Batya B. Davidovici;Naveed Sattar;Prinz C. Jörg;Luis Puig

  • Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities

    Brian J. Nickoloff;Frank O. Nestle

  • Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

    Niwa Ali;Niwa Ali;Bahar Zirak;Robert Sanchez Rodriguez;Mariela L. Pauli

  • Spontaneous Development of Psoriasis in a New Animal Model Shows an Essential Role for Resident T Cells and Tumor Necrosis Factor-α

    Onur Boyman;Hans Peter Hefti;Curdin Conrad;Brian J. Nickoloff

  • Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG

    D. Schadendorf;S. Ugurel;B. Schuler-Thurner;F.O. Nestle

  • Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets.

    F. O. Nestle;Xiang-Guang Zheng;C. B. Thompson;L. A. Turka

  • Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis

    Alexandros Onoufriadis;Michael A. Simpson;Andrew E. Pink;Paola Di Meglio

  • The architecture of gene regulatory variation across multiple human tissues: the MuTHER study

    Alexandra C. Nica;Alexandra C. Nica;Leopold Parts;Daniel Glass;James Nisbet

  • Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells.

    Takashi Murakami;Wusi Maki;Adela R. Cardones;Hui Fang

  • A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1

    A. Strange;F. Capon;C. C. A. Spencer;J. Knight

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    L. C. Tsoi;S. L. Spain;J. Knight;E. Ellinghaus

  • The IL-23/Th17 Axis in the Immunopathogenesis of

    Psoriasis Di Cesare;Paola Di Meglio;Frank O. Nestle

Frequent Co-Authors

Sophia N. Karagiannis
Sophia N. Karagiannis King's College London
Paola Di Meglio
Paola Di Meglio King's College London
Brian J. Nickoloff
Brian J. Nickoloff Loyola University Chicago
Günter Burg
Günter Burg University of Zurich
Reinhard Dummer
Reinhard Dummer University of Zurich
Jonathan Barker
Jonathan Barker King's College London
Richard C. Trembath
Richard C. Trembath King's College London
Francesca Capon
Francesca Capon King's College London
Michel Gilliet
Michel Gilliet University Hospital of Lausanne
Adrian Hayday
Adrian Hayday King's College London

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